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作者：Keneskhanova, Zhibek; Mcwilliam, Kirsty R.; Cosentino, Raul O.; Barcons-Simon, Anna; Dobrynin, Atai; Smith, Jaclyn E.; Subota, Ines; Mugnier, Monica R.; Colome-Tatche, Maria; Siegel, T. Nicolai
作者单位：University of Munich; University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of Edinburgh
摘要：Antigenic variation is an immune evasion strategy used by many different pathogens. It involves the periodic, non-random switch in the expression of different antigens throughout an infection. How the observed hierarchy in antigen expression is achieved has remained a mystery1,2. A key challenge in uncovering this process has been the inability to track transcriptome changes and potential genomic rearrangements in individual cells during a switch event. Here we report the establishment of a hi...
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作者：Rodriguez-Alvarez, Xose Pedro; Martinon-Torres, Maria
作者单位：Universitat Rovira i Virgili; Centro Nacional de Investigacion de La Evolucion Humana (CENIEH)
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作者：Tollefson, Jeff
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作者：Guo, Tiannan; Steen, Judith A.; Mann, Matthias
作者单位：Westlake University; Westlake Laboratory; Westlake University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Max Planck Society; University of Copenhagen
摘要：Mass-spectrometry (MS)-based proteomics has evolved into a powerful tool for comprehensively analysing biological systems. Recent technological advances have markedly increased sensitivity, enabling single-cell proteomics and spatial profiling of tissues. Simultaneously, improvements in throughput and robustness are facilitating clinical applications. In this Review, we present the latest developments in proteomics technology, including novel sample-preparation methods, advanced instrumentatio...
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作者：[Anonymous]
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作者：Proctor, Diana M.; Sansom, Sarah E.; Deming, Clay; Conlan, Sean; Blaustein, Ryan A.; Atkins, Thomas K.; NISC Comparative Sequencing Program, Jim; Mullikin, Jim; Thomas, Jim; Young, Alice; Bouffard, Gerry; Barnabas, Betty; Brooks, Shelise; Han, Joel; Buchter, Chloe; Ho, Shi-ling; Crawford, Juyun; Legaspi, Richelle; Maduro, Quino; Marfani, Holly; Montemayor, Casandra; Riebow, Nancy; Schandler, Karen; Schmidt, Brian; Sison, Christina; Stantripop, Mal; Black, Sean; Dekhtyar, Mila; Masiello, Cathy; McDowell, Jenny; Park, Morgan; Thomas, Pam; Vemulapalli, Meg; Dangana, Thelma; Fukuda, Christine; Thotapalli, Lahari; Kong, Heidi H.; Lin, Michael Y.; Hayden, Mary K.; Segre, Julia A.
作者单位：National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Rush University; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Texas System; University of Texas Health Science Center Houston; University System of Maryland; University of Maryland College Park; Princeton University
摘要：Antimicrobial resistance is a public health threat associated with increased morbidity, mortality and financial burden in nursing homes and other healthcare settings1. Residents of nursing homes are at increased risk of pathogen colonization and infection owing to antimicrobial-resistant bacteria and fungi. Nursing homes act as reservoirs, amplifiers and disseminators of antimicrobial resistance in healthcare networks and across geographical regions2. Here we investigate the genomic epidemiolo...
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作者：Zhou, Guangdi; Lv, Wei; Wang, Heng; Nie, Zihao; Chen, Yaqi; Li, Yueying; Huang, Haoliang; Chen, Wei-Qiang; Sun, Yu-Jie; Xue, Qi-Kun; Chen, Zhuoyu
作者单位：Southern University of Science & Technology; Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area; Southern University of Science & Technology; Quantum Science Center of Guangdong-HongKong-Macao Greater Bay Area; Tsinghua University
摘要：The discovery of Ruddlesden-Popper (RP) bilayer nickelate superconductors under high pressure has opened a new chapter in high-transition-temperature superconductivity1, 2, 3, 4, 5, 6, 7-8. However, the high-pressure conditions and presence of impurity phases have hindered comprehensive investigations into their superconducting properties and potential applications. Here we report ambient-pressure superconductivity onset above the McMillan limit (40 K) in RP bilayer nickelate epitaxial thin fi...
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作者：Wheeler, Michael A.; Quintana, Francisco J.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：The nervous and immune systems have complementary roles in the adaptation of organisms to environmental changes. However, the mechanisms that mediate cross-talk between the nervous and immune systems, called neuroimmune interactions, are poorly understood. In this Review, we summarize advances in the understanding of neuroimmune communication, with a principal focus on the central nervous system (CNS): its response to immune signals and the immunological consequences of CNS activity. We highli...
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作者：Peinado, Paola; Stazi, Marco; Ballabio, Claudio; Margineanu, Michael-Bogdan; Li, Zhaoqi; Colon, Caterina I.; Hsieh, Min-Shu; Pal Choudhuri, Shreoshi; Stastny, Victor; Hamilton, Seth; Le Marois, Alix; Collingridge, Jodie; Conrad, Linus; Chen, Yinxing; Ng, Sheng Rong; Magendantz, Margaret; Bhutkar, Arjun; Chen, Jin-Shing; Sahai, Erik; Drapkin, Benjamin J.; Jacks, Tyler; Vander Heiden, Matthew G.; Kopanitsa, Maksym V.; Robinson, Hugh P. C.; Li, Leanne
作者单位：Francis Crick Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); National Taiwan University; National Taiwan University Hospital; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Francis Crick Institute; University of Cambridge; National Taiwan University; National Taiwan University Hospital; National Taiwan University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Elevated or ectopic expression of neuronal receptors promotes tumour progression in many cancer types1,2; neuroendocrine (NE) transformation of adenocarcinomas has also been associated with increased aggressiveness3. Whether the defining neuronal feature, namely electrical excitability, exists in cancer cells and impacts cancer progression remains mostly unexplored. Small-cell lung cancer (SCLC) is an archetypal example of a highly aggressive NE cancer and comprises two major distinct subpopul...
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作者：Wang, Bo; Che, Zhiyuan; Cheng, Cheng; Tong, Caili; Shi, Lei; Shen, Yijie; Bliokh, Konstantin Y.; Zi, Jian
作者单位：Fudan University; Henan University; Henan Academy of Sciences; Fudan University; Nanyang Technological University; Nanyang Technological University; Hiroshima University; RIKEN
摘要：Topological wave structures, such as vortices1, 2, 3, 4, 5-6, polarization textures7, 8, 9, 10-11 and skyrmions12, 13, 14, 15, 16, 17, 18-19, appear in various quantum and classical wave fields, including optics and acoustics. In particular, optical vortices have found numerous applications20,21, ranging from quantum information to astrophysics. Furthermore, both optical and acoustic structured waves are crucial in the manipulation of small particles22, 23, 24-25, from atoms to macroscopic bio...
