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作者：Lee, Soyoung; Yu, Yong; Trimpert, Jakob; Benthani, Fahad; Mairhofer, Mario; Richter-Pechanska, Paulina; Wyler, Emanuel; Belenki, Dimitri; Kaltenbrunner, Sabine; Pammer, Maria; Kausche, Lea; Firsching, Theresa C.; Dietert, Kristina; Schotsaert, Michael; Martinez-Romero, Carles; Singh, Gagandeep; Kunz, Severine; Niemeyer, Daniela; Ghanem, Riad; Salzer, Helmut J. F.; Paar, Christian; Muelleder, Michael; Uccellini, Melissa; Michaelis, Edward G.; Khan, Amjad; Lau, Andrea; Schoenlein, Martin; Habringer, Anna; Tomasits, Josef; Adler, Julia M.; Kimeswenger, Susanne; Gruber, Achim D.; Hoetzenecker, Wolfram; Steinkellner, Herta; Purfuerst, Bettina; Motz, Reinhard; Di Pierro, Francesco; Lamprecht, Bernd; Osterrieder, Nikolaus; Landthaler, Markus; Drosten, Christian; Garcia-Sastre, Adolfo; Langer, Rupert; Ralser, Markus; Eils, Roland; Reimann, Maurice; Fan, Dorothy N. Y.; Schmitt, Clemens A.
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作者：Callaway, Ewen
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作者：Palsson, Gunnar; Hardarson, Marteinn T.; Jonsson, Hakon; Steinthorsdottir, Valgerdur; Stefansson, Olafur A.; Eggertsson, Hannes P.; Gudjonsson, Sigurjon A.; Olason, Pall I.; Gylfason, Arnaldur; Masson, Gisli; Thorsteinsdottir, Unnur; Sulem, Patrick; Helgason, Agnar; Gudbjartsson, Daniel F.; Halldorsson, Bjarni V.; Stefansson, Kari
作者单位：Decode Genetics; Reykjavik University; University of Iceland; University of Iceland; University of Iceland
摘要：Human recombination maps are a valuable resource for association and linkage studies and crucial for many inferences of population history and natural selection. Existing maps1, 2, 3, 4-5 are based solely on cross-over (CO) recombination, omitting non-cross-overs (NCOs)-the more common form of recombination6-owing to the difficulty in detecting them. Using whole-genome sequence data in families, we estimate the number of NCOs transmitted from parent to offspring and derive complete, sex-specif...
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作者：Marchand, Anthony; Buckley, Stephen; Schneuing, Arne; Pacesa, Martin; Elia, Maddalena; Gainza, Pablo; Elizarova, Evgenia; Neeser, Rebecca M.; Lee, Pao-Wan; Reymond, Luc; Miao, Yangyang; Scheller, Leo; Georgeon, Sandrine; Schmidt, Joseph; Schwaller, Philippe; Maerkl, Sebastian J.; Bronstein, Michael; Correia, Bruno E.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Swiss School of Public Health (SSPH+); Ecole Polytechnique Federale de Lausanne; University of Oxford; Austrian Academy of Sciences
摘要：Molecular recognition events between proteins drive biological processes in living systems1. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules2, 3, 4-5. Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field6,7. Here we present a computational strategy for the design of proteins that target neosurfaces, that is,...
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作者：[Anonymous]
摘要：In a few decades, gene-editing technologies could reduce the likelihood of common human diseases. Societies must use this time to prepare for their arrival. In a few decades, gene-editing technologies could reduce the likelihood of common human diseases. Societies must use this time to prepare for their arrival.
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作者：Fu, Xi; Mo, Shentong; Buendia, Alejandro; Laurent, Anouchka P.; Shao, Anqi; Alvarez-Torres, Maria del Mar; Yu, Tianji; Tan, Jimin; Su, Jiayu; Sagatelian, Romella; Ferrando, Adolfo A.; Ciccia, Alberto; Lan, Yanyan; Owens, David M.; Palomero, Teresa; Xing, Eric P.; Rabadan, Raul
作者单位：Columbia University; Columbia University; Mohamed bin Zayed University of Artificial Intelligence MBZUAI; Carnegie Mellon University; Columbia University; Columbia University; New York University; Regeneron; Columbia University; Tsinghua University; Tsinghua University; Columbia University
摘要：Transcriptional regulation, which involves a complex interplay between regulatory sequences and proteins, directs all biological processes. Computational models of transcription lack generalizability to accurately extrapolate to unseen cell types and conditions. Here we introduce GET (general expression transformer), an interpretable foundation model designed to uncover regulatory grammars across 213 human fetal and adult cell types1,2. Relying exclusively on chromatin accessibility data and s...
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作者：Won, Tae Hyung; Arifuzzaman, Mohammad; Parkhurst, Christopher N.; Miranda, Isabella C.; Zhang, Bingsen; Hu, Elin; Kashyap, Sanchita; Letourneau, Jeffrey; Jin, Wen-Bing; Fu, Yousi; Guzior, Douglas V.; Quinn, Robert A.; Guo, Chun-Jun; David, Lawrence A.; Artis, David; Schroeder, Frank C.
作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Duke University; Michigan State University; Michigan State University; Cornell University; Weill Cornell Medicine; Duke University; Cornell University; Weill Cornell Medicine; Pochon Cha University
摘要：Metabolites derived from the intestinal microbiota, including bile acids (BA), extensively modulate vertebrate physiology, including development(1), metabolism(2, 3-4), immune responses(5, 6-7) and cognitive function(8). However, to what extent host responses balance the physiological effects of microbiota-derived metabolites remains unclear(9,10). Here, using untargeted metabolomics of mouse tissues, we identified a family of BA-methylcysteamine (BA-MCY) conjugates that are abundant in the in...
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作者：Alang, Sirry
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
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作者：Shanker, Anil
作者单位：Meharry Medical College
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作者：King, Anthony
