Reinventing type 2 immunity in cancer

• 成果类型: Review
• 署名作者: Wagner, Marek; Nishikawa, Hiroyoshi; Koyasu, Shigeo
• 署名单位: Nagoya University; National Cancer Center - Japan; RIKEN
• 刊物名称: Nature
• ISSN/ISSBN: 0028-3355
• DOI: 10.1038/s41586-024-08194-2
• 发表日期: 2025-01-09
• 页码: 296-303
• 关键词: innate lymphoid-cells; mast-cells; gene-therapy; th2 cells; t-cells; eosinophils; inhibition; infection; rejection; interleukin-4

摘要

Our understanding of type 2 immunity has undergone a substantial transformation in recent years, revealing previously unknown functions. Beyond its canonical role in defence against parasitic helminth infections, type 2 immunity safeguards the host through additional mechanisms, including the suppression of excessive type 1 immune responses, regulation of tissue repair and maintenance of adipose tissue homeostasis. However, unlike type 1 immune responses, type 2 immunity is perceived as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective, painting a more nuanced picture in which type 2 immunity might protect against or even actively suppress tumour growth and progression. In this Review, we explore discoveries that highlight the potential of type 2 immunity in reshaping the landscape of cancer immunotherapies.