2025

最新文章

• The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy AI翻译
  作者：Bornes, Laura; van Winden, Lennart J.; Geurts, Veerle C. M.; de Bruijn, Beaunelle; Azarang, Leyla; Lanfermeijer, Mirthe; Caruso, Marika; Proost, Natalie; Boeije, Manon; Lohuis, Jeroen O.; Belthier, Guillaume; Delgado, Eulalia Noguera; de Gruil, Nadia; Kroep, Judith R.; van de Ven, Marieke; Menezes, Renee; Wesseling, Jelle; Kok, Marleen; Linn, Sabine; Broeks, Annegien; van Rossum, Huub H.; Scheele, Colinda L. G. J.; van Rheenen, Jacco
  作者单位：Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Flanders Institute for Biotechnology (VIB); KU Leuven; Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Netherlands Cancer Institute; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Netherlands Cancer Institute; Utrecht University; Netherlands Cancer Institute
  摘要：The response of breast cancer to neoadjuvant chemotherapy (NAC) varies substantially, even when tumours belong to the same molecular or histological subtype1. Here we identify the oestrous cycle as an important contributor to this heterogeneity. In three mouse models of breast cancer, we show reduced responses to NAC when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage. Similar findings were observed in retrospective premenopausal cohor...
• Chinese rice actually tastes ever more nice AI翻译
  作者：Lu, Lin; Hu, Xianqiao; Chen, Mingxue; Hu, Peisong
  作者单位：Chinese Academy of Agricultural Sciences; China National Rice Research Institute, CAAS
• Fibular reduction and the evolution of theropod locomotion AI翻译
  作者：Manafzadeh, Armita R.; Gatesy, Stephen M.; Nyakatura, John A.; Bhullar, Bhart-Anjan S.
  作者单位：Yale University; Yale University; Yale University; Brown University; Humboldt University of Berlin
  摘要：Since Hamp & eacute;'s classic developmental experiments in the mid-twentieth century1,2, the reduced avian fibula has sparked sustained curiosity3-6. The fibula transformed throughout dinosaur evolution from a columnar structure into its splint-like avian form, a change long thought to be of little biomechanical consequence3,6. Here we integrated comparative three-dimensional kinematic analyses with transitional morphologies from the fossil record to refute this assumption and show that the r...
• Pharmacological restoration of GTP hydrolysis by mutant RAS AI翻译
  作者：Cuevas-Navarro, Antonio; Pourfarjam, Yasin; Hu, Feng; Rodriguez, Diego J.; Vides, Alberto; Sang, Ben; Fan, Shijie; Goldgur, Yehuda; de Stanchina, Elisa; Lito, Piro
  作者单位：Memorial Sloan Kettering Cancer Center; Rockefeller University; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
  摘要：Approximately 3.4 million patients worldwide are diagnosed each year with cancers that have pathogenic mutations in one of three RAS proto-oncogenes (KRAS, NRAS and HRAS)1,2. These mutations impair the GTPase activity of RAS, leading to activation of downstream signalling and proliferation3, 4, 5-6. Long-standing efforts to restore the hydrolase activity of RAS mutants have been unsuccessful, extinguishing any consideration towards a viable therapeutic strategy7. Here we show that tri-complex ...
• A pulsar-like polarization angle swing from a nearby fast radio burst AI翻译
  作者：Mckinven, Ryan; Bhardwaj, Mohit; Eftekhari, Tarraneh; Kilpatrick, Charles D.; Kirichenko, Aida; Pal, Arpan; Cook, Amanda M.; Gaensler, B. M.; Giri, Utkarsh; Kaspi, Victoria M.; Michilli, Daniele; Nimmo, Kenzie; Pearlman, Aaron B.; Pleunis, Ziggy; Sand, Ketan R.; Stairs, Ingrid; Andersen, Bridget C.; Andrew, Shion; Bandura, Kevin; Brar, Charanjot; Cassanelli, Tomas; Chatterjee, Shami; Curtin, Alice P.; Dong, Fengqiu Adam; Eadie, Gwendolyn; Fonseca, Emmanuel; Ibik, Adaeze L.; Kaczmarek, Jane F.; Kharel, Bikash; Lazda, Mattias; Leung, Calvin; Li, Dongzi; Main, Robert; Masui, Kiyoshi W.; Mena-Parra, Juan; Ng, Cherry; Pandhi, Ayush; Patil, Swarali Shivraj; Prochaska, J. Xavier; Rafiei-Ravandi, Masoud; Scholz, Paul; Shah, Vishwangi; Shin, Kaitlyn; Smith, Kendrick
  作者单位：McGill University; McGill University; Carnegie Mellon University; Northwestern University; Northwestern University; Universidad Nacional Autonoma de Mexico; Tata Institute of Fundamental Research (TIFR); National Centre for Radio Astrophysics (NCRA), Pune; University of Toronto; University of Toronto; University of California System; University of California Santa Cruz; University of Wisconsin System; University of Wisconsin Madison; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Amsterdam; University of British Columbia; West Virginia University; Universidad de Chile; Cornell University; University of Toronto; University of Toronto; West Virginia University; Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of California System; University of California Berkeley; Princeton University; Universite de Orleans; Centre National de la Recherche Scientifique (CNRS); University of California System; University of California Santa Cruz; University of Tokyo; National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); York University - Canada; Perimeter Institute for Theoretical Physics
  摘要：Fast radio bursts (FRBs) last for milliseconds and arrive at Earth from cosmological distances. Although their origins and emission mechanisms are unknown, their signals bear similarities with the much less luminous radio emission generated by pulsars within our Miky Way Galaxy1, with properties suggesting neutron star origins2,3. However, unlike pulsars, FRBs typically show minimal variability in their linear polarization position angle (PA) curves4. Even when marked PA evolution is present, ...
• How to beat the biases harming women's mental health AI翻译
  作者：Chadha, Antonella Santuccione
• How Elon Musk's partnership with Trump could shape science in the US - and beyond AI翻译
  作者：Tollefson, Jeff
• Spatially restricted immune and microbiota-driven adaptation of the gut (dec, 10.1038/s41586-024-08216-z, 2024) AI翻译
  作者：Mayassi, Toufic; Li, Chenhao; Segerstolpe, Asa; Brown, Eric M.; Weisberg, Rebecca; Nakata, Toru; Yano, Hiroshi; Herbst, Paula; Artis, David; Graham, Daniel B.; Xavier, Ramnik J.
• Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson's disease could soon be here AI翻译
  作者：Abbott, Alison
• Endogenous self-peptides guard immune privilege of the central nervous system AI翻译
  作者：Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F. M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe, Clair; Artyomov, Maxim N.; Unanue, Emil R.; Kipnis, Jonathan
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); ITMO University; Washington University (WUSTL)
  摘要：Despite the presence of strategically positioned anatomical barriers designed to protect the central nervous system (CNS), it is not entirely isolated from the immune system1,2. In fact, it remains physically connected to, and can be influenced by, the peripheral immune system1. How the CNS retains such responsiveness while maintaining an immunologically unique status remains an outstanding question. Here, in searching for molecular cues that derive from the CNS and enable its direct communica...