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2025

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

主办单位: NATURE PORTFOLIO
期刊语言: 英语
创刊时间: 1869年
出版周期: 周刊
国际电子刊号: 1476-4687
影响因子: 42.779

最新文章

  • Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas
    作者：Monje, Michelle; Mahdi, Jasia; Majzner, Robbie; Yeom, Kristen W.; Schultz, Liora M.; Richards, Rebecca M.; Barsan, Valentin; Song, Kun-Wei; Kamens, Jen; Baggott, Christina; Kunicki, Michael; Rietberg, Skyler P.; Lim, Alexandria Sung; Reschke, Agnes; Mavroukakis, Sharon; Egeler, Emily; Moon, Jennifer; Patel, Shabnum; Chinnasamy, Harshini; Erickson, Courtney; Jacobs, Ashley; Duh, Allison K.; Tunuguntla, Ramya; Klysz, Dorota Danuta; Fowler, Carley; Green, Sean; Beebe, Barbara; Carr, Casey; Fujimoto, Michelle; Brown, Annie Kathleen; Petersen, Ann-Louise G.; McIntyre, Catherine; Siddiqui, Aman; Lepori-Bui, Nadia; Villar, Katlin; Pham, Kymhuynh; Bove, Rachel; Musa, Eric; Reynolds, Warren D.; Kuo, Adam; Prabhu, Snehit; Rasmussen, Lindsey; Cornell, Timothy T.; Partap, Sonia; Fisher, Paul G.; Campen, Cynthia J.; Grant, Gerald; Prolo, Laura; Ye, Xiaobu; Sahaf, Bita; Davis, Kara L.; Feldman, Steven A.; Ramakrishna, Sneha; Mackall, Crystal
    作者单位：Stanford University; Stanford University; Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford Medicine; Stanford University; Johns Hopkins University; Johns Hopkins Medicine; Stanford University
    摘要：H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models2. Arm A of Phase I trial no. NCT04196413 (ref. 3) administered one intravenous (IV) dose of autologous GD2-CART to patients with H3K27M-mutant pontine (DIPG) or spinal DMG (sDMG) at two dose levels (DL1, 1 x 106 kg-1; DL2, 3 x 106 kg-1) following lymphodepleting chemotherapy. Patients w...
  • Did Pluto 'kiss and capture' its largest moon?
    作者：Mitchinson, Andrew
  • AlphaFold 3 is great - but it still needs human help to get chemistry right
    作者：Steinkellner, Georg; Kroutil, Wolfgang; Gruber, Karl; Gruber, Christian C.
  • PhD parents: the pros and cons of having a child during your doctorate
    作者：Nowogrodzki, Julian
  • Philanthropic foundations must step in to shield science from Trump's cuts
    作者：Pierson, Leah; Pierson, Emma
    作者单位：Harvard University; Harvard Medical School; University of California System; University of California Berkeley
  • Why don't new memories overwrite old ones? Sleep science holds clues
    作者：Watson, Traci
    摘要：Research in mice points towards a mechanism that keeps old memories from being overwritten.
  • Cancer cells impair monocyte-mediated T cell stimulation to evade immunity
    作者：Elewaut, Anais; Estivill, Guillem; Bayerl, Felix; Castillon, Leticia; Novatchkova, Maria; Pottendorfer, Elisabeth; Hoffmann-Haas, Lisa; Schonlein, Martin; Nguyen, Trung Viet; Lauss, Martin; Andreatta, Francesco; Vulin, Milica; Krecioch, Izabela; Bayerl, Jonas; Pedde, Anna-Marie; Fabre, Naomi; Holstein, Felix; Cronin, Shona M.; Rieser, Sarah; Laniti, Denarda Dangaj; Barras, David; Coukos, George; Quek, Camelia; Bai, Xinyu; Munoz i Ordono, Miquel; Wiesner, Thomas; Zuber, Johannes; Jonsson, Goran; Bottcher, Jan P.; Vanharanta, Sakari; Obenauf, Anna C.
    作者单位：Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); Vienna Biocenter (VBC); University of Vienna; Medical University of Vienna; Technical University of Munich; University of Helsinki; Lund University; University of Lausanne; Ludwig Institute for Cancer Research; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; University of Sydney; Melanoma Institute Australia; University of Sydney; University of Sydney; Medical University of Vienna; University of Helsinki
    摘要：The tumour microenvironment is programmed by cancer cells and substantially influences anti-tumour immune responses1,2. Within the tumour microenvironment, CD8+ T cells undergo full effector differentiation and acquire cytotoxic anti-tumour functions in specialized niches3-7. Although interactions with type 1 conventional dendritic cells have been implicated in this process3-5,8-10, the underlying cellular players and molecular mechanisms remain incompletely understood. Here we show that infla...
  • What will viruses do next? AI is helping scientists predict their evolution
    作者：Mallapaty, Smriti
  • Mapping the ionosphere with millions of phones (vol 635, pg 365, 2024)
    作者：Smith, Jamie; Kast, Anton; Geraschenko, Anton; Morton, Y. Jade; Brenner, Michael P.; van Diggelen, Frank; Williams, Brian P.
  • How to sustain scientific collaboration amid worsening US-China relations
    作者：Karplus, Valerie J.; Xue, Lan; Morgan, M. Granger; He, Kebin; Victor, David G.; Zhang, Shuang-Nan
    作者单位：Carnegie Mellon University; Carnegie Mellon University; Tsinghua University; Tsinghua University; Carnegie Mellon University; Tsinghua University; Tsinghua University; University of California System; University of California San Diego; Brookings Institution; Chinese Academy of Sciences; Institute of High Energy Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS