2025

最新文章

• Common and rare variant associations with clonal haematopoiesis phenotypes (vol 612, pg 301, 2022) AI翻译
  作者：Kessler, Michael D.; Damask, Amy; O'Keeffe, Sean; Banerjee, Nilanjana; Li, Dadong; Watanabe, Kyoko; Marketta, Anthony; Van Meter, Michael; Semrau, Stefan; Horowitz, Julie; Tang, Jing; Kosmicki, Jack A.; Rajagopal, Veera M.; Zou, Yuxin; Houvras, Yariv; Ghosh, Arkopravo; Gillies, Christopher; Mbatchou, Joelle; White, Ryan R.; Verweij, Niek; Bovijn, Jonas; Parikshak, Neelroop N.; Leblanc, Michelle G.; Jones, Marcus; Glass, David J.; Lotta, Luca A.; Cantor, Michael N.; Atwal, Gurinder S.; Locke, Adam E.; Ferreira, Manuel A. R.; Deering, Raquel; Paulding, Charles; Shuldiner, Alan R.; Thurston, Gavin; Ferrando, Adolfo A.; Salerno, Will; Reid, Jeffrey G.; Overton, John D.; Marchini, Jonathan; Kang, Hyun M.; Baras, Aris; Abecasis, Goncalo R.; Jorgenson, Eric
  作者单位：Regeneron; Regeneron
• How a small but mighty protein protects a life-sustaining enzyme AI翻译
  作者：Rosenzweig, Amy C.
  作者单位：Northwestern University; Northwestern University
• Central control of dynamic gene circuits governs T cell rest and activation AI翻译
  作者：Arce, Maya M.; Umhoefer, Jennifer M.; Arang, Nadia; Kasinathan, Sivakanthan; Freimer, Jacob W.; Steinhart, Zachary; Shen, Haolin; Pham, Minh T. N.; Ota, Mineto; Wadhera, Anika; Dajani, Rama; Dorovskyi, Dmytro; Chen, Yan Yi; Liu, Qi; Zhou, Yuan; Swaney, Danielle L.; Obernier, Kirsten; Shy, Brian R.; Carnevale, Julia; Satpathy, Ansuman T.; Krogan, Nevan J.; Pritchard, Jonathan K.; Marson, Alexander
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Stanford University; Stanford University; Stanford University; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; Stanford University; University of California System; University of California Berkeley; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks1, 2-3. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The need for context-dependent regulation is prominent in T cells, where distinct lineages must respond to diverse signals to mount effective immune responses and maintain homeostasis4, 5, 6, 7-8. Here we performed CRISP...
• Organ-specific sympathetic innervation defines visceral functions AI翻译
  作者：Wang, Tongtong; Teng, Bochuan; Yao, Dickson R.; Gao, Wei; Oka, Yuki
  作者单位：California Institute of Technology; California Institute of Technology
  摘要：The autonomic nervous system orchestrates the functions of the brain and body through the sympathetic and parasympathetic pathways1. However, our understanding of the autonomic system, especially the sympathetic system, at the cellular and molecular levels is severely limited. Here we show topological representations of individual visceral organs in the major abdominal sympathetic ganglion complex. Using multi-modal transcriptomic analyses, we identified molecularly distinct sympathetic popula...
• Oxidative cyclization reagents reveal tryptophan cation-π interactions (vol 627, pg 680, 2024) AI翻译
  作者：Xie, Xiao; Moon, Patrick J.; Crossley, Steven W. M.; Bischoff, Amanda J.; He, Dan; Li, Gen; Dao, Nam; Gonzalez-Valero, Angel; Reeves, Audrey G.; Mckenna, Jeffrey M.; Elledge, Susanna K.; Wells, James A.; Toste, F. Dean; Chang, Christopher J.
• Neuromorphic computing at scale AI翻译
  作者：Kudithipudi, Dhireesha; Schuman, Catherine; Vineyard, Craig M.; Pandit, Tej; Merkel, Cory; Kubendran, Rajkumar; Aimone, James B.; Orchard, Garrick; Mayr, Christian; Benosman, Ryad; Hays, Joe; Young, Cliff; Bartolozzi, Chiara; Majumdar, Amitava; Cardwell, Suma George; Payvand, Melika; Buckley, Sonia; Kulkarni, Shruti; Gonzalez, Hector A.; Cauwenberghs, Gert; Thakur, Chetan Singh; Subramoney, Anand; Furber, Steve
  作者单位：University of Texas System; University of Texas at San Antonio; University of Tennessee System; University of Tennessee Knoxville; United States Department of Energy (DOE); Sandia National Laboratories; Rochester Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Intel Corporation; Intel USA; Technische Universitat Dresden; United States Department of Defense; United States Navy; United States Naval Research Laboratory; Alphabet Inc.; DeepMind; Istituto Italiano di Tecnologia - IIT; University of California System; University of California San Diego; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); Oak Ridge National Laboratory; Indian Institute of Science (IISC) - Bangalore; University of London; Royal Holloway University London; University of Manchester
  摘要：Neuromorphic computing is a brain-inspired approach to hardware and algorithm design that efficiently realizes artificial neural networks. Neuromorphic designers apply the principles of biointelligence discovered by neuroscientists to design efficient computational systems, often for applications with size, weight and power constraints. With this research field at a critical juncture, it is crucial to chart the course for the development of future large-scale neuromorphic systems. We describe ...
• A deep catalogue of protein-coding variation in 983,578 individuals (vol 631, pg 583, 2024) AI翻译
  作者：Sun, Kathie Y.; Bai, Xiaodong; Chen, Siying; Bao, Suying; Zhang, Chuanyi; Kapoor, Manav; Backman, Joshua; Joseph, Tyler; Maxwell, Evan; Mitra, George; Gorovits, Alexander; Mansfield, Adam; Boutkov, Boris; Gokhale, Sujit; Habegger, Lukas; Marcketta, Anthony; Locke, Adam E.; Ganel, Liron; Hawes, Alicia; Kessler, Michael D.; Sharma, Deepika; Staples, Jeffrey; Bovijn, Jonas; Gelfman, Sahar; Di Gioia, Alessandro; Rajagopal, Veera M.; Lopez, Alexander; Varela, Jennifer Rico; Alegre-Diaz, Jesus; Berumen, Jaime; Tapia-Conyer, Roberto; Kuri-Morales, Pablo; Torres, Jason; Emberson, Jonathan; Collins, Rory; Cantor, Michael; Thornton, Timothy; Kang, Hyun Min; Overton, John D.; Shuldiner, Alan R.; Cremona, M. Laura; Nafde, Mona; Baras, Aris; Abecasis, Gonccalo; Marchini, Jonathan; Reid, Jeffrey G.; Salerno, William; Balasubramanian, Suganthi
• Ab initio characterization of protein molecular dynamics with AI2BMD (vol 635, pg 1019, 2024) AI翻译
  作者：Wang, Tong; He, Xinheng; Li, Mingyu; Li, Yatao; Bi, Ran; Wang, Yusong; Cheng, Chaoran; Shen, Xiangzhen; Meng, Jiawei; Zhang, He; Liu, Haiguang; Wang, Zun; Li, Shaoning; Shao, Bin; Liu, Tie-Yan
  作者单位：Microsoft; Microsoft China
• Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers AI翻译
  作者：Steffin, David; Ghatwai, Nisha; Montalbano, Antonino; Rathi, Purva; Courtney, Amy N.; Arnett, Azlann B.; Fleurence, Julien; Sweidan, Ramy; Wang, Tao; Zhang, Huimin; Masand, Prakash; Maris, John M.; Martinez, Daniel; Pogoriler, Jennifer; Varadarajan, Navin; Thakkar, Sachin G.; Lyon, Deborah; Lapteva, Natalia; Zhuyong, Mei; Patel, Kalyani; Lopez-Terrada, Dolores; Ramos, Carlos A.; Lulla, Premal; Armaghany, Tannaz; Grilley, Bambi J.; Gottschalk, Stephen; Dotti, Gianpietro; Metelitsa, Leonid S.; Heslop, Helen E.; Brenner, Malcolm K.; Sumazin, Pavel; Heczey, Andras
  作者单位：Texas Children's Cancer Center; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Houston Methodist; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Houston System; University of Houston; Baylor College of Medicine; University of North Carolina; University of North Carolina Chapel Hill; Baylor College of Medicine; Baylor College Medical Hospital
  摘要：Interleukin-15 (IL-15) promotes the survival of T lymphocytes and enhances the antitumour properties of chimeric antigen receptor (CAR) T cells in preclinical models of solid neoplasms in which CAR T cells have limited efficacy1-4. Glypican-3 (GPC3) is expressed in a group of solid cancers5-10, and here we report the evaluation in humans of the effects of IL-15 co-expression on GPC3-expressing CAR T cells (hereafter GPC3 CAR T cells). Cohort 1 patients (NCT02905188 and NCT02932956) received GP...
• H5N1 clade 2.3.4.4b dynamics in experimentally infected calves and cows AI翻译
  作者：Halwe, Nico Joel; Cool, Konner; Breithaupt, Angele; Schoen, Jacob; Trujillo, Jessie D.; Nooruzzaman, Mohammed; Kwon, Taeyong; Ahrens, Ann Kathrin; Britzke, Tobias; Mcdowell, Chester D.; Piesche, Ronja; Singh, Gagandeep; dos Reis, Vinicius Pinho; Kafle, Sujan; Pohlmann, Anne; Gaudreault, Natasha N.; Corleis, Bjoern; Ferreyra, Franco Matias; Carossino, Mariano; Balasuriya, Udeni B. R.; Hensley, Lisa; Morozov, Igor; Covaleda, Lina M.; Diel, Diego G.; Ulrich, Lorenz; Hoffmann, Donata; Beer, Martin; Richt, Juergen A.
  作者单位：Friedrich Loeffler Institute; Kansas State University; Friedrich Loeffler Institute; Cornell University; Friedrich Loeffler Institute; Kansas State University; Louisiana State University System; Louisiana State University; Louisiana State University School of Veterinary Medicine; Louisiana State University School of Veterinary Medicine; Louisiana State University System; Louisiana State University; United States Department of Agriculture (USDA)
  摘要：In March 2024, highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b H5N1 infections were reported in dairy cows in Texas, USA1. Rapid dissemination to more than 380 farms in 14 states followed2. Here we provide results of two independent clade 2.3.4.4b experimental infection studies evaluating the oronasal susceptibility to and transmission of a US H5N1 bovine isolate, genotype B3.13 (H5N1 B3.13), in calves, and the susceptibility of lactating cows following direct mammary gland inoc...