2025

最新文章

• Why AI will never be able to acquire human-level intelligence AI翻译
  作者：Munoz, Jose M.; Bernacer, Javier; Noe, Alva; Thompson, Evan
  作者单位：University of Navarra; University of California System; University of California Berkeley; University of British Columbia
• Clouds reduce downwelling longwave radiation over land in a warming climate AI翻译
  作者：Liu, Lei; Huang, Yi; Gyakum, John R.
  作者单位：McGill University
  摘要：Clouds greatly influence the Earth's energy balance1,2. Observationally constraining cloud radiative feedback, a notably uncertain climate feedback mechanism3, 4-5, is crucial for improving predictions of climate change5, 6-7 but, so far, remains an elusive objective, and the feedback may be different over the ocean versus over land8, 9-10. Here we show a local negative surface longwave cloud feedback over land at the southern Great Plains site, constrained by direct long-term observation of s...
• Bilayer nanographene reveals halide permeation through a benzene hole AI翻译
  作者：Niyas, M. A.; Shoyama, Kazutaka; Gruene, Matthias; Wuerthner, Frank
  作者单位：University of Wurzburg; University of Wurzburg
  摘要：Graphene is a single-layered sp2-hybridized carbon allotrope, which is impermeable to all atomic entities other than hydrogen1,2. The introduction of defects allows selective gas permeation3, 4-5; efforts have been made to control the size of these defects for higher selectivity6, 7, 8-9. Permeation of entities other than gases, such as ions10,11, is of fundamental scientific interest because of its potential application in desalination, detection and purification12, 13, 14, 15-16. However, a ...
• Two companies launch Moon missions together: will they make history? AI翻译
  作者：Witze, Alexandra
• A foundation model of transcription across human cell types AI翻译
  作者：Fu, Xi; Mo, Shentong; Buendia, Alejandro; Laurent, Anouchka P.; Shao, Anqi; Alvarez-Torres, Maria del Mar; Yu, Tianji; Tan, Jimin; Su, Jiayu; Sagatelian, Romella; Ferrando, Adolfo A.; Ciccia, Alberto; Lan, Yanyan; Owens, David M.; Palomero, Teresa; Xing, Eric P.; Rabadan, Raul
  作者单位：Columbia University; Columbia University; Mohamed bin Zayed University of Artificial Intelligence MBZUAI; Carnegie Mellon University; Columbia University; Columbia University; New York University; Regeneron; Columbia University; Tsinghua University; Tsinghua University; Columbia University
  摘要：Transcriptional regulation, which involves a complex interplay between regulatory sequences and proteins, directs all biological processes. Computational models of transcription lack generalizability to accurately extrapolate to unseen cell types and conditions. Here we introduce GET (general expression transformer), an interpretable foundation model designed to uncover regulatory grammars across 213 human fetal and adult cell types1,2. Relying exclusively on chromatin accessibility data and s...
• Progressive plasticity during colorectal cancer metastasis AI翻译
  作者：Moorman, A. R.; Benitez, E. K.; Cambuli, F.; Jiang, Q.; Mahmoud, A.; Lumish, M.; Hartner, S.; Balkaran, S.; Bermeo, J.; Asawa, S.; Firat, C.; Saxena, A.; Wu, F.; Luthra, A.; Burdziak, C.; Xie, Y.; Sgambati, V.; Luckett, K.; Li, Y.; Yi, Z.; Masilionis, I.; Soares, K.; Pappou, E.; Yaeger, R.; Kingham, P.; Jarnagin, W.; Paty, P.; Weiser, M. R.; Mazutis, L.; D'Angelica, M.; Shia, J.; Garcia-Aguilar, J.; Nawy, T.; Hollmann, T. J.; Chaligne, R.; Sanchez-Vega, F.; Sharma, R.; Pe'er, D.; Ganesh, K.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Howard Hughes Medical Institute; University System of Ohio; Case Western Reserve University; Bristol-Myers Squibb
  摘要：As cancers progress, they become increasingly aggressive-metastatic tumours are less responsive to first-line therapies than primary tumours, they acquire resistance to successive therapies and eventually cause death1,2. Mutations are largely conserved between primary and metastatic tumours from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression and therapy resistance3-5. However, we lack an understanding of metastatic cell states and th...
• Hidden tattoos on mummy skin emerge under a laser's light AI翻译
  作者：[Anonymous]
• AI learns from chromatin data to uncover gene interactions AI翻译
  作者：Brozek, Alicja; Theodoris, Christina V.
  作者单位：University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco
• How to navigate uncertainty in an unpredictable world AI翻译
  作者：Min, Yongyi
  摘要：A statistician offers a masterful guide to embracing the unknown.
• Why we still don't know the mounting health risks of climate change AI翻译
  作者：Mitchell, Dann
  作者单位：University of Bristol