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作者：Tai, Lee-Hwa
作者单位：University of Sherbrooke
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作者：Kasstan-Dabush, Ben; Gur-Arie, Rachel
作者单位：University of Edinburgh; Arizona State University; Arizona State University-Downtown Phoenix
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作者：Lavandero, Sergio
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作者：Orthwein, Alexandre; Noordermeer, Sylvie M.; Wilson, Marcus D.; Landry, Sebastien; Enchev, Radoslav I.; Sherker, Alana; Munro, Meagan; Pinder, Jordan; Salsman, Jayme; Dellaire, Graham; Xia, Bing; Peter, Matthias; Durocher, Daniel
作者单位：University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Toronto; Dalhousie University; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers Cancer Institute of New Jersey; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
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作者：[Anonymous]
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作者：Liu, C. M.; Zhao, B. N.; Cao, J. B.; Pollock, C. J.; Russell, C. T.; Liu, Y. Y.; Xing, X. N.; Linqvist, P. A.; Burch, J. L.
作者单位：Beihang University; University of California System; University of California Los Angeles; Royal Institute of Technology; Southwest Research Institute
摘要：Chorus waves are some of the strongest electromagnetic emissions naturally occurring in space and can cause radiation that is hazardous to humans and satellites1, 2-3. Although chorus waves have attracted extreme interest and been intensively studied for decades4, 5, 6-7, their generation and evolution remain highly debated7. Here, in contrast to the conventional expectation that chorus waves are governed by planetary magnetic dipolar fields5,7, we report observations of repetitive, rising-ton...
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作者：Xing, Huaipeng; Rosenkranz, Remus R. E.; Rodriguez-Aliaga, Piere; Lee, Ting-Ting; Majtner, Tomas; Boehm, Stefanie; Turonova, Beata; Frydman, Judith; Beck, Martin
作者单位：Max Planck Society; Goethe University Frankfurt; Stanford University; Goethe University Frankfurt
摘要：The ring-shaped chaperonin T-complex protein ring complex (TRiC; also known as chaperonin containing TCP-1, CCT) is an ATP-driven protein-folding machine that is essential for maintenance of cellular homeostasis1,2. Its dysfunction is related to cancer and neurodegenerative disease3,4. Despite its importance, how TRiC works in the cell remains unclear. Here we structurally analysed the architecture, conformational dynamics and spatial organization of the chaperonin TRiC in human cells using cr...
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作者：Roure, Baptiste; Alonso, Maialen; Lonardi, Giovanni; Yildiz, Dilara Berna; Buettner, Cornelia S.; dos Santos, Thiago; Xu, Yan; Bossart, Martin; Derdau, Volker; Mendez, Maria; Llaveria, Josep; Ruffoni, Alessandro; Leonori, Daniele
作者单位：University of Manchester; RWTH Aachen University; Gazi University; Sanofi-Aventis; Sanofi Germany; Johnson & Johnson; Johnson & Johnson Spain
摘要：Thiazoles and isothiazoles are privileged motifs in drug and agrochemical discovery1,2. The synthesis of these derivatives is generally approached, designed and developed on a case-by-case basis. Sometimes, the lack of robust synthesis methods to a given target can pose considerable difficulties or even thwart the preparation of specific derivatives for further study3,4. Here we report a conceptually different approach in which photochemical irradiation can be used to alter the structure of th...
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作者：Guglielmi, Giorgia
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作者：Jones, Nicola
