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作者：Franke, Philipp; Freiberger, Simon; Zhang, Lin; Einsle, Oliver
作者单位：University of Freiburg
摘要：The oxygen-sensitive molybdenum-dependent nitrogenase of Azotobacter vinelandii is protected from oxidative damage by a reversible 'switch-off' mechanism1. It forms a complex with a small ferredoxin, FeSII (ref. 2) or the 'Shethna protein II'3, which acts as an O2 sensor and associates with the two component proteins of nitrogenase when its [2Fe:2S] cluster becomes oxidized4,5. Here we report the three-dimensional structure of the protective ternary complex of the catalytic subunit of Mo-nitro...
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作者：Xuan, Jerry W.; Oppenheimer, Rebecca
作者单位：California Institute of Technology; American Museum of Natural History (AMNH)
摘要：The nearby star Gliese 229 harbours a 'brown dwarf' companion: an object less massive than a star but more massive than a planet. High-resolution observations reveal that it is two objects, each about 30 times the mass of Jupiter, that circle one another every 12 days as they orbit their sun every few hundred years.
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作者：Jacobson, Julie
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作者：Tollefson, Jeff
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作者：[Anonymous]
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作者：Jian, Fanchong; Wang, Jing; Yisimayi, Ayijiang; Song, Weiliang; Xu, Yanli; Chen, Xiaosu; Niu, Xiao; Yang, Sijie; Yu, Yuanling; Wang, Peng; Sun, Haiyan; Yu, Lingling; Wang, Jing; Wang, Yao; An, Ran; Wang, Wenjing; Ma, Miaomiao; Xiao, Tianhe; Gu, Qingqing; Shao, Fei; Wang, Youchun; Shen, Zhongyang; Jin, Ronghua; Cao, Yunlong
作者单位：Peking University; Changping Laboratory; Peking University; Peking University; Capital Medical University; Nankai University; Tsinghua University; Peking University; National Institute of Biological Sciences, Beijing; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Medical Biology - CAMS; Nankai University
摘要：The continuous evolution of SARS-CoV-2, particularly the emergence of the BA.2.86/JN.1 lineage replacing XBB, necessitates re-evaluation of vaccine compositions1, 2-3. Here, we provide a comprehensive analysis of the humoral immune response to XBB and JN.1 human exposure. We demonstrate the antigenic distinctiveness of XBB and JN.1 lineages in SARS-CoV-2-naive individuals and show that infection with JN.1 elicits superior plasma neutralization against its subvariants. We highlight the strong i...
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作者：Jones, Nicola
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作者：Nogrady, Bianca
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作者：Zheng, Qingfei; Weekley, Benjamin H.; Vinson, David A.; Zhao, Shuai; Bastle, Ryan M.; Thompson, Robert E.; Stransky, Stephanie; Ramakrishnan, Aarthi; Cunningham, Ashley M.; Dutta, Sohini; Chan, Jennifer C.; Di Salvo, Giuseppina; Chen, Min; Zhang, Nan; Wu, Jinghua; Fulton, Sasha L.; Kong, Lingchun; Wang, Haifeng; Zhang, Baichao; Vostal, Lauren; Upad, Akhil; Dierdorff, Lauren; Shen, Li; Molina, Henrik; Sidoli, Simone; Muir, Tom W.; Li, Haitao; David, Yael; Maze, Ian
作者单位：James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; Tsinghua University; Princeton University; Yeshiva University; Maastricht University; Memorial Sloan Kettering Cancer Center; Rockefeller University; Shanxi Medical University; Tsinghua University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Icahn School of Medicine at Mount Sinai; Howard Hughes Medical Institute; Icahn School of Medicine at Mount Sinai; Purdue University System; Purdue University
摘要：Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1, 2-3. We previously demonstrated that serotonylation4, 5, 6, 7, 8, 9-10 and dopaminylation9,11, 12-13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states. Here we found that TG2 additionally functions as an eraser and exchanger of H3 monoaminylation...
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作者：Horne, Richard B.
