Science

最新文章

• Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration AI翻译
  作者：Li, Yulin; Li, Zhiguo; Zheng, Pei; Guan, Shuzhen; Li, Yan; Yao, Nan; Qi, Zhihui; Zhang, Xueyu; Su, Lei; Jing, Jing; Wu, Siting; Zhao, Xue; Wang, Meng; Bottcher, Chotima; Ljunggren, Hans-Gustaf; Paul, Friedemann; Van Kaer, Luc; Verkhratsky, Alexei; Shi, Fu-Dong
  作者单位：Tianjin Medical University; Capital Medical University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Karolinska Institutet; Karolinska University Hospital; Vanderbilt University; University of Manchester
  摘要：Multiple sclerosis (MS) progresses through brain region-specific inflammation and degeneration, with poorly defined mechanisms. In individuals with MS, we identified increased expression of formyl peptide receptor 1 (FPR1) in central nervous system (CNS)-resident microglia and CNS-infiltrating macrophages. Blood amounts of N-formylated peptides, which are endogenous agonists of FPR1, correlated with disease progression in patients with MS. In MS mouse models, signaling through FPR1 promoted mi...
• Idea that gut microbes contribute to autism draws fire AI翻译
  作者：O'Grady, Cathleen
• PIEZO channels link mechanical forces to uterine contractions in parturition AI翻译
  作者：Zhang, Yunxiao; Kini, Sejal A.; Mishkanian, Sassan A.; Yarishkin, Oleg; Luo, Renhao; Seradj, Saba Heydari; Leung, Verina H.; Wang, Yu; Servin-Vences, M. Rocio; Keenan, William T.; Sonmez, Utku; Sanchez-Alavez, Manuel; Liu, Yuejia; Jin, Xin; Lipomi, Darren J.; Ye, Li; Petrascheck, Michael; Frolova, Antonina I.; England, Sarah K.; Patapoutian, Ardem
  作者单位：Scripps Research Institute; Howard Hughes Medical Institute; University of California System; University of California San Diego; Scripps Research Institute; Universidad Autonoma de Baja California
  摘要：Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. We identified mechanically activated ion channels PIEZO1 and PIEZO2 as key mechanotransducers required for labor progression. Genetic deletion of Piezo1 and Piezo2 in mice resulted in weakened uterine contractions and severe parturition defects. Tissue-specific knockouts revealed that deletion in either uterus or sensory neurons alone caused modest defects w...
• Protect Iraq's Mesopotamian Marshes AI翻译
  作者：Latif, Sarmad Dashti
• Chimpanzees rationally revise their beliefs AI翻译
  作者：Schleihauf, Hanna; Sanford, Emily M.; Thompson, Bill D.; Zhang, Snow; Rukundo, Joshua; Call, Josep; Herrmann, Esther; Engelmann, Jan M.
  作者单位：Utrecht University; Leibniz Association; Deutsches Primatenzentrum (DPZ); University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of St Andrews; University of St Andrews; University of Portsmouth
  摘要：The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined whether and how chimpanzees (Pan troglodytes) update their initial belief about the location of a reward in response to conflicting evidence. Chimpanzees responded to counterevidence in ways predicted by a formal model of rational belief revision: They remained committed to their initial belief w...
• US should expand EIA requirements AI翻译
  作者：Powers, Sean P.; Lehrter, John
  作者单位：University of South Alabama
• Higher education fails at collective action AI翻译
  作者：Thorp, H. Holden
• Free global access to climate and weather data must continue AI翻译
  作者：Taalas, Petteri
  作者单位：Finnish Meteorological Institute
• THIS IS FOR EVERYONE AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
• The EPA's shaken foundation AI翻译
  作者：Frey, H. Christopher
  作者单位：North Carolina State University