Science

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• Low-quality papers surge thanks to public data and AI AI翻译
  作者：O'Grady, Cathleen
• Project to revive Louisiana coastline runs aground AI翻译
  作者：Cornwall, Warren
  摘要：Politics and lawsuits imperil plans to divert the Mississippi River to build new land
• De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts AI翻译
  作者：Hou, Kaipeng; Huang, Wei; Qi, Miao; Tugwell, Thomas H.; Alturaifi, Turki M.; Chen, Yuda; Zhang, Xingjie; Lu, Lei; Mann, Samuel I.; Liu, Peng; Yang, Yang; DeGrado, William F.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Santa Barbara; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California Riverside; University of California System; University of California Santa Barbara
  摘要：De novo design of protein catalysts with high efficiency and stereoselectivity provides an attractive approach toward the design of environmentally benign catalysts. Here, we design proteins that incorporate histidine-ligated synthetic porphyrin and heme ligands. Four of 10 designed proteins catalyzed cyclopropanation with an enantiomeric ratio greater than 99:1. A second class of proteins were designed to catalyze a silicon-hydrogen insertion and were optimized by directed evolution in whole ...
• How Trump upended science AI翻译
  作者：Malakoff, David
• Measurements of molecular size and shape on a chip AI翻译
  作者：Zhu, Xin; Bennett, Timothy J. D.; Zouboulis, Konstantin C.; Soulias, Dimitrios; Grzybek, Michal; Benesch, Justin L. P.; El-Sagheer, Afaf H.; Coskun, Uenal; Krishnan, Madhavi
  作者单位：University of Oxford; University of Oxford; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; University of Southampton; University of Southampton; Technische Universitat Dresden; Carl Gustav Carus University Hospital; German Center for Diabetes Research (DZD); Max Planck Society
• Pericytes protect brain capillaries from pressure AI翻译
  作者：Funk, Michael
• ECONOMIC RESEARCH Trade war is 'natural experiment' for economists AI翻译
  作者：Charles, Dan
• Giant croc family tree revised AI翻译
  作者：Servick, Kelly
• Catching a glimpse of ancient Mars AI翻译
  作者：Bishop, Janice L.; Lane, Melissa D.
  作者单位：SETI Institute
• Structural pathway for PI3-kinase regulation by VPS15 in autophagy AI翻译
  作者：Cook, Annan S. I.; Chen, Minghao; Nguyen, Thanh N.; Cabezudo, Ainara Claveras; Khuu, Grace; Rao, Shanlin; Garcia, Samantha N.; Yang, Mingxuan; Iavarone, Anthony T.; Ren, Xuefeng; Lazarou, Michael; Hummer, Gerhard; Hurley, James H.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Walter & Eliza Hall Institute; University of Melbourne; Monash University; Max Planck Society; Max Planck Society; Goethe University Frankfurt; University of California System; University of California Berkeley
  摘要：The class III phosphatidylinositol-3 kinase complexes I and II (PI3KC3-C1 and PI3KC3-C2) have vital roles in macroautophagy and endosomal maturation, respectively. We elucidated a structural pathway of enzyme activation through cryo-electron microscopy analysis of PI3KC3-C1. The inactive conformation of the VPS15 pseudokinase stabilizes the inactive conformation, sequestering its N-myristate in the N-lobe of the pseudokinase. Upon activation, the myristate is liberated such that the VPS34 lipi...