Science

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• Can AI simplify the alphabet of life? Generative AI design yields functional proteins with only 19 amino acids AI翻译
  作者：Sanfiorenzo, Charles; Wang, Kaihang
  作者单位：California Institute of Technology
• When ties unravel AI翻译
  作者：Yang, Jiang
  作者单位：Sun Yat Sen University
• Mesothermic fishes face high fuel demands and overheating risk in warming oceans AI翻译
  作者：Payne, Nicholas L.; Snelling, Edward P.; Peralta-Maraver, Ignacio; Cade, David E.; Chapple, Taylor K.; McInturf, Alexandra G.; Watanabe, Yuuki Y.; Sims, David W.; Queiroz, Nuno; da Costa, Ivo; Sousa, Lara L.; Goldbogen, Jeremy A.; Dolton, Haley R.; Jackson, Andrew L.
  作者单位：Trinity College Dublin; University of Pretoria; University of Pretoria; University of Granada; University of Granada; Stanford University; Oregon State University; Graduate University for Advanced Studies - Japan; Marine Biological Association United Kingdom; University of Southampton; NERC National Oceanography Centre; Universidade do Porto
  摘要：Body size and temperature set metabolic rates and the pace of life, yet our understanding of the energetics of large fishes is uncertain, especially of warm-bodied mesotherms, which can heavily influence marine food webs. We developed an approach to estimate metabolic heat production in fishes, revealing how routine energy expenditure scales with size and temperature from 1-milligram larvae up to 3-tonne megaplanktivorous sharks. We found that mesotherms use approximately four times more energ...
• Pesticides may wreak havoc on the gut microbiome Disruption of complex intestinal ecosystem could contribute to diabetes and other health issues, scientists say AI翻译
  作者：Jain, Sanket
• We survived COVID-19-Are we ready for Nipah? AI翻译
  作者：Khan, Sikandar; Zhang, Ruiyong; Khan, Alamgir; Shah, Abdullah; Tan, Qinghai
  作者单位：Chinese Academy of Sciences; Institute of Oceanology, CAS; Huazhong University of Science & Technology
• Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response AI翻译
  作者：Reineke, Lucas C.; Zhu, Ping Jun; Dalwadi, Udit; Dooling, Sean W.; Liu, Yuwei; Wang, I-Ching; Young-Baird, Sara; Okoh, James; Kuncha, Santosh Kumar; Zhou, Hongyi; Kannan, Akshara; Park, Hyekyung; Debeaubien, Nicolas A.; Croll, Tristan; Lee, D. John; Arthur, Christopher; Dever, Thomas E.; Walter, Peter; Chen, Jin; Frost, Adam; Costa-Mattioli, Mauro
  作者单位：Baylor College of Medicine; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); Uniformed Services University of the Health Sciences - USA
  摘要：The integrated stress response (ISR) is essential for cellular homeostasis and cognitive function. We investigated how persistent ISR activation affects cognitive performance by studying the PPP1R15BR658C genetic variant associated with intellectual disability. To model this condition, we generated a mouse line with the pathogenic allele inserted. This variant destabilized the PPP1R15B center dot PP1 phosphatase complex, causing persistent ISR activation, impaired protein synthesis, and long-t...
• United States cuts ties with WHO's cancer research arm AI翻译
  作者：Kaiser, Jocelyn
• Multistep genomics on single cells and live cultures in subnanoliter capsules AI翻译
  作者：Mazelis, Ignas; Sun, Haoxiang; Kulkarni, Arpita; Torre, Theresa L.; Klein, Allon M.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
  摘要：Single-cell sequencing methods uncover natural and induced variation between cells. Many functional genomic methods, however, require multiple steps that cannot yet be scaled to high throughput, including assays on living cells. In this study, we developed capsules with amphiphilic gel envelopes (CAGEs), which selectively retain cells and large analytes while being freely accessible to media, enzymes, and reagents. Capsules enable high-throughput multistep assays combining live-cell culture wi...
• Structural modeling reveals phage proteins that manipulate bacterial immune signaling AI翻译
  作者：Tal, Nitzan; Hadary, Romi; Chang, Renee B.; Osterman, Ilya; Jacobson, Roy; Yirmiya, Erez; Bechon, Nathalie; Hochhauser, Dina; Lopez Rivera, Miguel; Madhala, Barak; Garb, Jeremy; Goldsmith, Moshe; Wein, Tanita; Kranzusch, Philip J.; Amitai, Gil; Sorek, Rotem
  作者单位：Weizmann Institute of Science; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and biophysical traits shared by diverse viral antidefense proteins and used these traits to develop a computational pipeline that predicts phage proteins whose role is to manipulate bacterial immune signaling. Experimental validation revealed three previously uncharacterized protein families-Sequestin, Lo...
• Deciphering D AI翻译
  作者：Cohen, Jon
  作者单位：Universidad Autonoma de Nuevo Leon