-
作者：Mitchell, Melanie
-
作者：Simanshu, Dhirendra K.; Xu, Rui; Stice, James P.; Czyzyk, Daniel J.; Feng, Siyu; Denson, John-Paul; Riegler, Erin; Yang, Yue; Zhang, Cathy; Donovan, Sofia; Smith, Brian P.; Abreu-Blanco, Maria; Chen, Ming; Feng, Cindy; Fu, Lijuan; Rabara, Dana; Young, Lucy C.; Dyba, Marcin; Yan, Wupeng; Lin, Ken; Ghorbanpoorvalukolaie, Samar; Larsen, Erik K.; Malik, Wafa; Champagne, Allison; Parker, Katie; Ju, Jin Hyun; Jeknic, Stevan; Esposito, Dominic; Turner, David M.; Lightstone, Felice C.; Wang, Bin; Wehn, Paul M.; Wang, Keshi; Stephen, Andrew G.; Maciag, Anna E.; Hata, Aaron N.; Sinkevicius, Kerstin W.; Nissley, Dwight V.; Wallace, Eli M.; McCormick, Frank; Beltran, Pedro J.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要：BBO-10203 is an orally available drug that covalently and specifically binds to the rat sarcoma (RAS)-binding domain of phosphoinositide 3-kinase alpha (PI3K alpha), preventing its activation by HRAS, NRAS, and KRAS. It inhibited PI3K alpha activation in tumors with oncogenic mutations in KRAS or PIK3CA and in tumors with human epidermal growth factor receptor 2 (HER2) amplification or overexpression. In preclinical models, BBO-10203 caused significant tumor growth inhibition across multiple t...
-
作者：Thorp, H. Holden
-
作者：Zhang, Yichao; Ahammed, Ballal; Bae, Sang Hyun; Lee, Chia-Hao; Huang, Jeffrey; Hossain, Mohammad Abir; Rakib, Tawfiqur; van der Zande, Arend M.; Ertekin, Elif; Huang, Pinshane Y.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University System of Maryland; University of Maryland College Park; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Twisted two-dimensional materials exhibit distinctive vibrational modes called moir & eacute; phonons, which arise from the moir & eacute; superlattice. Here, we demonstrate atom-by-atom imaging of phasons, an ultrasoft class of moir & eacute; phonons in twisted bilayer tungsten diselenide (WSe2). Using ultrahigh-resolution (<15 picometers) electron ptychography, we imaged the size and shape of each atom to extract time-averaged vibrational amplitudes as a function of twist angle and position....
-
作者：Lenormand, Thomas; Roze, Denis
作者单位：Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Sorbonne Universite
摘要：Sex chromosomes are involved in three major empirical patterns: (i) Y (or W) chromosomes are often nonrecombining and degenerate; (ii) heterogametic offspring (XY or ZW) from interspecific crosses are more often sterile or inviable compared with homogametic offspring (Haldane's rule); and (iii) the X (or Z) has a disproportionately large effect on reproductive isolation between species compared with autosomes (the large X effect). Each observation has received its own tailored explanation invo...
-
作者：Cohen, Jon
-
作者：Hartmann, Marcus D.
作者单位：Max Planck Society; Eberhard Karls University of Tubingen
-
作者：Schuster, Thomas; Haferkamp, Jonas; Huang, Hsin-Yuan
作者单位：California Institute of Technology; California Institute of Technology; Alphabet Inc.; Google Incorporated; Saarland University; Massachusetts Institute of Technology (MIT)
摘要：Random unitaries are central to quantum technologies and the study of complex quantum many-body physics. However, existing protocols for generating random unitaries require long evolution times and deep circuits. In this work, we prove that local quantum circuits can form random unitaries in extremely low depth on any geometry. These shallow circuits have low complexity and create only short-range correlations, yet are indistinguishable from random unitaries with exponential complexity. This f...
-
作者：Chen, Fu
作者单位：Hohai University
-
作者：Large, Christopher R. L.; Khanal, Rupa; Hillier, LaDeana; Huynh, Chau; Kubo, Connor; Kim, Junhyong; Waterston, Robert H.; Murray, John I.
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; University of Washington; University of Washington Seattle
摘要：The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous cells. The conserved invariant embryonic lineage of Caenorhabditis elegans and C. briggsae makes them ideal for comparing cell type gene expression across evolution. Measuring the spatiotemporal divergence of gene expression across embryogenesis, we find a high level of similarity in gene expressi...
