Science

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• Study of South Asian genomes illuminates roots of milk drinking AI翻译
  作者：Price, Michael
• LIFE ON A LITTLE-KNOWN PLANET AI翻译
  作者：Bowser, Gillian
  作者单位：Colorado State University System; Colorado State University Fort Collins
• An all-seeing eye on the sky AI翻译
  作者：Clery, Daniel
• Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness AI翻译
  作者：Cosgrove, Brian D.; Bounds, Lexi R.; Taylor, Carson Key; Su, Alan L.; Rizzo, Anthony J.; Barrera, Alejandro; Sun, Tongyu; Safi, Alexias; Song, Lingyun; Whitlow, Thomas; Tata, Aleksandra; Iglesias, Nahid; Diao, Yarui; Tata, Purushothama Rao; Hoffman, Brenton D.; Crawford, Gregory E.; Gersbach, Charles A.
  作者单位：Duke University; Duke University; Duke University; Duke University; Duke University; Duke University; Duke University; Duke University
  摘要：Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcription remains largely unmapped. In this study, we combined genome-wide epigenome profiling, epigenome editing, and phenotypic and single-cell RNA sequencing CRISPR screening to identify a class of genomic enhancers that responds to the mechanical microenvironment. These mechanoenhancers can be prefe...
• 'Functional cure' for HIV comes closer to reality AI翻译
  作者：Cohen, Jon
• Cracking chemistry with quantum simulations AI翻译
  作者：Schleich, Philipp; Aspuru-Guzik, Alan
  作者单位：University of Toronto; Vector Institute for Artificial Intelligence; University of Toronto; Canadian Institute for Advanced Research (CIFAR); University of Toronto; University of Toronto
  摘要：Dynamic characteristics of complex chemical reactions can be accurately modeled by a quantum computer
• A writing pact AI翻译
  作者：Shah, Arjav
  作者单位：Massachusetts Institute of Technology (MIT)
• Elasticity of davemaoite as a primary contributor to lower-mantle heterogeneities AI翻译
  作者：Zhou, Wen-Yi; Hao, Ming; Su, Wenhao; Kim, Taehyun; Chen, Sibo; Shim, Sang-Heon; Zhang, Dongzhou; Nguyen, Phuong Q. H.; Armstrong, Katherine; Zhang, Jin S.
  作者单位：Texas A&M University System; Texas A&M University College Station; University of Bayreuth; Swiss Federal Institutes of Technology Domain; ETH Zurich; Arizona State University; Arizona State University-Tempe; University of Chicago; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Santa Cruz
  摘要：Geophysical detection of subducted mid-ocean ridge basalt (MORB) in the lower mantle is hindered by uncertainties in the elasticity of Fe,Al,Mg,Ti-bearing davemaoite, a key MORB component. Using Brillouin spectroscopy and x-ray diffraction, we determined the elasticity of a Ca0.906(1)Fe2+0.027(1)Fe3+0.042(1)Mg0.033(1)Al0.072(1)Ti0.020(1)Si0.912(1)O3 davemaoite up to 113 gigapascals and 2294 K. We found that it exhibited a shear wave velocity 10 to 20% slower than end-member davemaoite, making ...
• Multigas adsorption with single-site cooperativity in a metal-organic framework AI翻译
  作者：Carsch, Kurtis M.; Jiang, Henry Z. H.; Klein, Ryan A.; Rosen, Andrew S.; Summerhill, Peyton S.; Peltier, Jesse L.; Huang, Adrian J.; Murphy, Ryan A.; Dods, Matthew N.; Silva, Hope A.; Hasanbasri, Zikri; Kwon, Hyunchul; Karstens, Sarah L.; Yabuuchi, Yuto; Borgel, Jonas; Taylor, Jordan W.; Meihaus, Katie R.; Bustillo, Karen C.; Minor, Andrew M.; Persson, Kristin A.; Brown, Craig M.; Britt, R. David; Stadie, Nicholas P.; Long, Jeffrey R.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Princeton University; Montana State University System; Montana State University Bozeman; University of California System; University of California Berkeley; University of California System; University of California Davis; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Delaware
  摘要：Cooperative gas adsorption in metal-organic frameworks (MOFs) is a rare phenomenon that generally involves long-range communication between multiple binding sites. We demonstrate a MOF containing cobalt(II)-methyl sites that selectively and reversibly capture two carbon monoxide (CO) molecules per site, leading to record-high adsorption capacities at ambient temperatures and pressures. Gas adsorption and structural, spectroscopic, and computational analyses support a mechanism in which binding...
• Tracking magma with earthquakes AI翻译
  作者：Pinel, Virginie
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Institut de Recherche pour le Developpement (IRD); Universite Gustave-Eiffel; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)