Science

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• In vivo hematopoietic stem cell modification by mRNA delivery (jun, 10.1126/science.adz0744, 2025) AI翻译
  作者：Breda, Laura; Papp, Tyler E.; Triebwasser, Michael P.; Yadegari, Amir; Fedorky, Megan T.; Tanaka, Naoto; Abdulmalik, Osheiza; Pavani, Giulia; Wang, Yongping; Grupp, Stephan A.; Chou, Stella T.; Ni, Houping; Mui, Barbara L.; Tam, Ying K.; Weissman, Drew; Rivella, Stefano; Parhiz, Hamideh
• Studies making lasting paradigm shifts are on the rise AI翻译
  作者：Brainard, Jeffrey
• Remobilized metals threaten urban wetlands AI翻译
  作者：Li, Chengjun; Li, Shouying; Zhou, Qinghua; Tang, Wenli; Zhong, Huan
  作者单位：Guangzhou University; Nanjing Institute of Environmental Sciences, Ministry of Ecology & Environment; Nanjing University; Sichuan Agricultural University
• Arctic bird nesting traces back to the Cretaceous AI翻译
  作者：Wilson, Lauren N.; Ksepka, Daniel T.; Wilson, John P.; Gardner, Jacob D.; Erickson, Gregory M.; Brinkman, Donald; Brown, Caleb M.; Eberle, Jaelyn J.; Organ, Chris L.; Druckenmiller, Patrick S.
  作者单位：University of Alaska System; University of Alaska Fairbanks; University of Alaska System; University of Alaska Fairbanks; Princeton University; University of Reading; State University System of Florida; Florida State University; University of Alberta; University of Manitoba; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Montana State University System; Montana State University Bozeman
  摘要：Polar ecosystems are structured and enriched by birds, which nest there seasonally and serve as keystone ecosystem members. Despite the ecological importance of polar birds, the origins of high-latitude nesting strategies remain obscured by a sparse fossil record. We report an extreme-latitude Arctic avialan assemblage from the Prince Creek Formation of Alaska-the northernmost Late Cretaceous terrestrial ecosystem. Numerous three-dimensionally preserved fossils constitute one of the most taxon...
• Enamel proteins reveal biological sex and genetic variability in southern African Paranthropus AI翻译
  作者：Madupe, Palesa P.; Koenig, Claire; Patramanis, Ioannis; Ruther, Patrick L.; Hlazo, Nomawethu; Mackie, Meaghan; Tawane, Mirriam; Krueger, Johanna; Taurozzi, Alberto J.; Troche, Gaudry; Kibii, Job; Pickering, Robyn; Dickinson, Marc R.; Sahle, Yonatan; Kgotleng, Dipuo; Musiba, Charles; Manthi, Fredrick; Bell, Liam; DuPlessis, Michelle; Gilbert, Catherine; Zipfel, Bernhard; Kuderna, Lukas F. K.; Lizano, Esther; Welker, Frido; Kyriakidou, Pelagia; Cox, Juergen; Mollereau, Catherine; Tokarski, Caroline; Blackburn, Jonathan; Ramos-Madrigal, Jazmin; Marques-Bonet, Tomas; Penkman, Kirsty; Zanolli, Clement; Schroeder, Lauren; Racimo, Fernando; Olsen, Jesper V.; Ackermann, Rebecca R.; Cappellini, Enrico
  作者单位：University of Copenhagen; University of Cape Town; University of Copenhagen; University of Cape Town; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Barcelona Biomedical Research Park; University of Cape Town; University of York - UK; University of Johannesburg; Duke University; Universite de Bordeaux; University of Witwatersrand; Autonomous University of Barcelona; Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Max Planck Society; University of Bergen; Universite de Toulouse; University of Cape Town; ICREA; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); University of Toronto; University Toronto Mississauga; University College Dublin; University of Turin; University of Witwatersrand; Illumina
  摘要：Paranthropus robustus is a morphologically well-documented Early Pleistocene hominin species from southern Africa with no genetic evidence reported so far. In this work, we describe the mass spectrometric sequencing of enamel peptides from four similar to 2 million-year-old dental specimens attributed morphologically to P. robustus from the site of Swartkrans in South Africa. The identification of AMELY-specific peptides enabled us to assign two specimens to male individuals, whereas semiquant...
• Researchers question Abbott's rapid malaria tests AI翻译
  作者：Offord, Catherine
• A wave of emotion AI翻译
  作者：Karamihalev, Stoyo; Gogolla, Nadine
  作者单位：Max Planck Society
  摘要：Sustained brainwide patterns of activity enable emotions to outlast their triggers
• BRAF oncogenic mutants evade autoinhibition through a common mechanism AI翻译
  作者：Lavoie, Hugo; Jin, Ting; Lajoie, Driss; Decossas, Marion; Gendron, Patrick; Wang, Bing; Filandr, Frantisek; Sahmi, Malha; Jo, Chang Hwa; Weber, Sandra; Arseneault, Genevieve; Tripathy, Sasmita; Beaulieu, Pierre; Schuetz, Doris A.; Schriemer, David C.; Marinier, Anne; Rice, William J.; Maisonneuve, Pierre; Therrien, Marc
  作者单位：Universite de Montreal; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); NYU Langone Medical Center; University of Calgary; Universite de Montreal; NYU Langone Medical Center; Universite de Montreal
  摘要：Uncontrolled activation of the rat sarcoma (RAS)-extracellular signal-regulated kinase (ERK) pathway drives tumor growth, often because of oncogenic BRAF mutations. BRAF regulation, involving monomeric autoinhibition and activation by dimerization, has been intensely scrutinized, but mechanisms enabling oncogenic mutants to evade regulation remain unclear. By using cryo-electron microscopy, we solved the three-dimensional structures of the three oncogenic BRAF mutant classes, including the com...
• Glacier preservation doubled by limiting warming to 1.5°C versus 2.7°C AI翻译
  作者：Zekollari, Harry; Schuster, Lilian; Maussion, Fabien; Hock, Regine; Marzeion, Ben; Rounce, David R.; Compagno, Loris; Fujita, Koji; Huss, Matthias; James, Megan; Kraaijenbrink, Philip D. A.; Lipscomb, William H.; Minallah, Samar; Oberrauch, Moritz; Van Tricht, Lander; Champollion, Nicolas; Edwards, Tamsin; Farinotti, Daniel; Immerzeel, Walter; Leguy, Gunter; Sakai, Akiko
  作者单位：Vrije Universiteit Brussel; Swiss Federal Institutes of Technology Domain; ETH Zurich; Universite Libre de Bruxelles; University of Innsbruck; University of Bristol; University of Oslo; University of Alaska System; University of Alaska Fairbanks; University of Bremen; University of Bremen; Carnegie Mellon University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Nagoya University; University of Fribourg; University of London; King's College London; Utrecht University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Swiss Federal Institutes of Technology Domain; ETH Zurich; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
  摘要：Glaciers adapt slowly to changing climatic conditions, with long-term implications for sea-level rise and water supply. Using eight glacier models, we simulated global glacier evolution over multicentennial timescales, allowing glaciers to equilibrate with climate under various constant global temperature scenarios. We estimate that glaciers globally will lose 39 (range, 15 to 55)% of their mass relative to 2020, corresponding to a global mean sea-level rise of 113 (range, 43 to 204) mm even i...
• China sets out to sample an unusual asteroid AI翻译
  作者：Normile, Dennis