Science

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• Aberrant basal cell clonal dynamics shape early lung carcinogenesis AI翻译
  作者：Gomez-Lopez, Sandra; Alhendi, Ahmed S. N.; Przybilla, Moritz J.; Bordeu, Ignacio; Whiteman, Zoe E.; Butler, Timothy; Rouhani, Maral J.; Kalinke, Lukas; Uddin, Imran; Otter, Kate E. J.; Chandrasekharan, Deepak P.; Lebrusant-Fernandez, Marta; Shurr, Abigail Y. L.; Durrenberger, Pascal F.; Moore, David A.; Falzon, Mary; Reading, James L.; Martincorena, Inigo; Simons, Benjamin D.; Campbell, Peter J.; Janes, Sam M.
  作者单位：University of London; University College London; Wellcome Trust Sanger Institute; Universidad de Chile; University of London; University College London; University of London; University College London; University of London; University College London; Cancer Research UK; University of London; University College London; University College London Hospitals NHS Foundation Trust; University of London; University College London; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of London; University College London; University College London Hospitals NHS Foundation Trust
  摘要：Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we found that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and basal cell mobilization along the airways. Ultimately, preinvasive lesions developed from a few highly mutated clones that dominate most of the...
• Rethinking jaundice A buildup of unconjugated bilirubin may be a protective response to malaria AI翻译
  作者：Kloehn, Joachim; Soldati-Favre, Dominique
  作者单位：University of Geneva
• Gate-driven band modulation hyperdoping for high-performance p-type 2D semiconductor transistors AI翻译
  作者：Zhao, Bei; Zhang, Zucheng; Xu, Junqing; Guo, Dingli; Gu, Tiancheng; He, Guiming; Lu, Ping; He, Kun; Li, Jia; Chen, Zhao; Ren, Quan; Miao, Lin; Lu, Junpeng; Ni, Zhenhua; Duan, Xiangfeng; Duan, Xidong
  作者单位：Hunan University; Southeast University - China; Southeast University - China; Hefei University of Technology; Southeast University - China; University of California System; University of California Los Angeles
  摘要：Tailoring carrier density in atomically thin two-dimensional (2D) semiconductors is challenging because of the inherently limited physical space for incorporating charge dopants. Here, we report that interlayer charge-transfer doping in type III van der Waals heterostructures can be greatly modulated by an external gate to realize a hyperdoping effect. Systematic gated-Hall measurements revealed that the modulated carrier density is about five times that of the gate capacitive charge, achievin...
• Bridging the divide: Why the science-policy interface matters for global food systems AI翻译
  作者：Elouafi, Ismahane
• New case law and liability risks for manufacturers of medical AI AI翻译
  作者：Gerke, Sara; Simon, David A.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Northeastern University
• How burnout snuck up on me AI翻译
  作者：Xames, M. D. Doulotuzzaman
  作者单位：Virginia Polytechnic Institute & State University
• Africa's epidemic of low-quality medicines AI翻译
  作者：Hamill, Heather; Zeng, Fanqi; Mariwah, Simon
  作者单位：University of Oxford; University of Cape Coast
• THE SALMON CANNON AND THE LEVITATING FROG AI翻译
  作者：Kemp, Christopher
  作者单位：Michigan State University
• Resilience is my strength AI翻译
  作者：Delgado, Jary Y.
  作者单位：Loyola University Chicago
• Passive cooling paint enabled by rational design of thermal-optical and mass transfer properties AI翻译
  作者：Fei, Jipeng; Zhang, Xuan; Han, Di; Lei, Yue; Xie, Fei; Zhou, Kai; Koh, See-Wee; Ge, Junyu; Zhou, Hao; Wang, Xingli; Wu, Xinghui; Tan, Jun-Yan; Gu, Yuheng; Long, Yongping; Koh, Zhi Hui; Wang, Su; Du, Panwei; Mi, Tangwei; Ng, Bing-Feng; Cai, Lili; Feng, Chi; Gan, Qiaoqiang; Li, Hong
  作者单位：Nanyang Technological University; Beijing Institute of Technology; King Abdullah University of Science & Technology; Chinese Academy of Sciences; Changchun Institute of Optics, Fine Mechanics & Physics, CAS; University of Illinois System; University of Illinois Urbana-Champaign; Nanyang Technological University; University of Dundee; Chongqing University; King Abdullah University of Science & Technology
  摘要：Integrating radiative and evaporative cooling shows promise for enhancing passive cooling, but durable self-curing integrated cooling paints remain underdeveloped. We designed a modified cementitious structure with advanced thermal-optical and mass transfer properties, boosting cooling power while ensuring durability, mechanical strength, and broad adhesion. The paint achieves 88 to 92% solar reflectance (depending on wetting), 95% atmospheric window emittance, similar to 30% water retention, ...