Science

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• In vivo CAR T cell generation to treat cancer and autoimmune disease AI翻译
  作者：Hunter, Theresa L.; Bao, Yanjie; Zhang, Yan; Matsuda, Daiki; Riener, Romina; Wang, Annabel; Li, John J.; Soldevila, Ferran; Chu, David S. H.; Nguyen, Duy P.; Yong, Qian-Chen; Ross, Brittany; Nguyen, Michelle; Vestal, James; Roberts, Scott; Galvan, Diana; Vega, Jerel Boyd; Jhung, Donald; Butcher, Matthew; Nguyen, Josephine; Zhang, Stanley; Fernandez, Claudia; Chen, Jeffrey; Herrera, Carolina; Kuo, Yi; Pica, E. Michael; Mondal, Goutam; Mammen, Andrew L.; Scholler, John; Tanis, Steven P.; Sievers, Stuart A.; Frantz, Aric M.; Adams, Gregor B.; Shawver, Laura; Farzaneh-Far, Ramin; Rosenzweig, Michael; Karmali, Priya P.; Bot, Adrian I.; June, Carl H.; Aghajanian, Haig
  作者单位：National Institutes of Health (NIH) - USA; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity for lymphodepleting chemotherapy, restricting patient accessibility. We present an in vivo engineering strategy using targeted lipid nanoparticles (tLNPs) for messenger RNA delivery to specific T cell subsets. These tLNPs reprogrammed CD8(+) T cells in both healthy donor and autoimmune patient samp...
• Torn between two worlds AI翻译
  作者：Kirby, Georgina
  作者单位：University of Gottingen
• Poleward greening of the global oceans AI翻译
  作者：Kudela, Raphael M.
  作者单位：University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz
• US BUDGET Congress shows signs of resisting proposed science cuts AI翻译
  作者：Charles, Dan
• Bacterial reverse transcriptase synthesizes long poly(A)-rich cDNA for antiphage defense AI翻译
  作者：Song, Xin-Yi; Xia, Yushan; Zhang, Jun-Tao; Liu, Yu-Jun; Qi, Hua; Wei, Xin-Yang; Hu, Hailiang; Xia, Yu; Liu, Xue; Ma, Ying-Fei; Jia, Ning
  作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Shenzhen University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Southern University of Science & Technology; Southern University of Science & Technology
  摘要：Prokaryotic defense-associated reverse transcriptases (DRTs) were recently identified with antiviral functions; however, their functional mechanisms remain largely unexplored. Here we show that DRT9 forms a hexameric complex with its upstream noncoding RNA (ncRNA) to mediate antiphage defense by inducing cell growth arrest through abortive infection. Upon phage infection, the phage-encoded ribonucleotide reductase NrdAB complex increases intracellular deoxyadenosine triphosphate levels, activa...
• Satellite swarms mar Rubin's pristine view AI翻译
  作者：Clery, Daniel
• Remembering China's coastal mudflats AI翻译
  作者：Chen, Fu
  作者单位：Hohai University
• Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae AI翻译
  作者：Large, Christopher R. L.; Khanal, Rupa; Hillier, LaDeana; Huynh, Chau; Kubo, Connor; Kim, Junhyong; Waterston, Robert H.; Murray, John I.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Washington; University of Washington Seattle
  摘要：The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous cells. The conserved invariant embryonic lineage of Caenorhabditis elegans and C. briggsae makes them ideal for comparing cell type gene expression across evolution. Measuring the spatiotemporal divergence of gene expression across embryogenesis, we find a high level of similarity in gene expressi...
• Tasting opportunity AI翻译
  作者：Rowland, Hannah M.; Schneider, Eve R.
  作者单位：University of Liverpool; University of Kentucky
• Neuroinflammation across neurological diseases AI翻译
  作者：Shi, Fu-Dong; Yong, V. Wee
  作者单位：Capital Medical University; Tianjin Medical University; University of Calgary; University of Calgary
  摘要：The brain's response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the flame of the brain. Although details differ and matter, neuroinflammation exacerbating neurodegeneration has similarities across multiple sclerosis and other neurological disorders, such as stroke and neurodegenerative diseases. Thus, lessons from successful disease-modifying therapies in multiple sclerosis may provide insights into strate...