Neuroinflammation across neurological diseases

• 成果类型: Review
• 署名作者: Shi, Fu-Dong; Yong, V. Wee
• 署名单位: Capital Medical University; Tianjin Medical University; University of Calgary; University of Calgary
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13362
• DOI: 10.1126/science.adx0043
• 发表日期: 2025-06-19
• 关键词: multiple-sclerosis lesions; ischemic-stroke action; microglial activation; t-cells; alzheimers-disease; brain parenchyma; white-matter; single-cell; fingolimod; pathology

摘要

The brain's response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the flame of the brain. Although details differ and matter, neuroinflammation exacerbating neurodegeneration has similarities across multiple sclerosis and other neurological disorders, such as stroke and neurodegenerative diseases. Thus, lessons from successful disease-modifying therapies in multiple sclerosis may provide insights into strategies for modulating neuroinflammation and reducing neural injury in other neurological conditions. In this Review, we discuss these lessons and potential strategies for counteracting neuroinflammation, including taming the microglia-orchestrated brain immune responses that contribute to progressing neuropathology.