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作者：Nelson, Alondra
作者单位：Institute for Advanced Study - USA
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作者：Ozawa, Shinzaburo; Munekane, Hiroshi; Suito, Hisashi; Yarai, Hiroshi
摘要：Using Global Navigation Satellite System data, we investigated the interplate slip before, during, and after the 2024 Hyuga-nada earthquake in Japan. Before the earthquake, a moment magnitude (Mw) 6.0 slow-slip event (SSE) was observed from late 2023 in a downdip extension of the mainshock. The coseismic slip was adjacent to the 1996 Hyuga-nada earthquake source. The afterslip resolved near the hypocenter area and in the downdip extension of the mainshock, reaching Mw 6.7 on 16 September 2024....
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作者：Ma, Wei Jen; Wang, Changqing; Kothandapani, Jagatheeswaran; Luzentales-Simpson, Matthew; Menzies, Susan C.; Bescucci, Danisa M.; Lange, Maximo E.; Fraser, Alexander S. C.; Gusse, Jenny F.; House, Kathaleen E.; Moote, Paul E.; Xing, Xiaohui; Grondin, Julie M.; Hui, Benjamin Wei-Qiang; Clarke, Sandra T.; Shelton, Tara G.; Haskey, Natasha; Gibson, Deanna L.; Martens, Eric C.; Abbott, D. Wade; Inglis, G. Douglas; Sly, Laura M.; Brumer, Harry
作者单位：University of British Columbia; University of British Columbia; BC Children's Hospital; University of British Columbia; University of British Columbia; Agriculture & Agri Food Canada; University of British Columbia; University of British Columbia Okanagan; University of Michigan System; University of Michigan
摘要：The gut microbiota of mammals possess distinctive metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system, called GlycoCaging, that is based on bespoke glycoconjugates of a complex plant oligosaccharide. GlycoCaging of exemplar anti-inflammatory drugs enabled release of active molecules triggered by specific glycosidases of autochthonous gut bacteria. GlycoCaging ensu...
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作者：Edgington, Joshua R.; Saffer, Demian M.; Williams, Charles A.
作者单位：University of Texas System; University of Texas Austin; GNS Science - New Zealand
摘要：Patterns of strain accumulation and release offshore in subduction zones are directly linked to the potential for shallow coseismic slip and tsunamigenesis, but these patterns remain elusive. In this work, we analyze formation pore pressure records from three offshore borehole observatories at the Nankai subduction zone, Honshu, Japan, to capture detailed slip-time histories of two slow slip events (SSEs) along the outermost reaches of the plate boundary. Slip initiates similar to 30 kilometer...
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作者：Zhang, Zining; Dong, Guangbin
作者单位：University of Chicago
摘要：In drug development, replacement of a skeletal carbon with a sulfur atom can result in analogs of bioactive compounds with improved properties. Currently, the sulfur analogs are almost exclusively prepared by de novo synthesis; the existing approach to swap carbon with sulfur is inefficient and involves stoichiometric mercury reagents. In this study, we report a two-step carbonyl-to-sulfur (CO-to-S) atom swap approach, enabled by a rationally designed N '-alkyl-hydrazonamide (NAHA) reagent tha...
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作者：Obara, Kazushige
作者单位：National Research Institute for Earth Science & Disaster Resilience
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作者：Langin, Katie
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作者：Kanter, Benjamin R.; Lykken, Christine M.; Polti, Ignacio; Moser, May-Britt; Moser, Edvard I.
作者单位：Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU)
摘要：Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we simultaneously recorded hundreds to thousands of neurons in the lateral entorhinal cortex of freely behaving rats. Neural population activity drifted continuously along a one-dimensional manifold during all behaviors and behavioral states, including sleep, which points to an intrinsic origin of t...
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作者：Gilette, Nicole M.; Lipton, Jonathan O.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School
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作者：Sinnott-Armstrong, Nasa; Forsythe, Desiree; Benoit, Jane M.; Chappell, Callie R.; Coe, Lisa S. Y.; de Oliveira, Bruno Francesco Rodrigues; Evans, Natalya; Fagre, Anna C.; Gilligan, Jonathan M.; Hamilton, Maria; Henneberry, Colin Moran; Ishaq, Suzanne L.; Johnston, Juliet; Krichilsky, Erin; Lopez, Jamie Alcira; McMonigal, Kay; de la Campa, Melanie Ortiz Alvarez; Rahman, Rahmeen; Schwartz, Nicole E.; Talluto, Lauren; Taylor, Eric J.; Vargas-Muniz, Jose M.; Weissman, J. L.
作者单位：Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Santa Clara University; State University System of Florida; Florida State University; Stanford University; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Universidade Federal Fluminense; University of California System; University of California Santa Barbara; Colorado State University System; Colorado State University Fort Collins; Vanderbilt University; Vanderbilt University; University System of Georgia; University of Georgia; State University of New York (SUNY) System; Stony Brook University; University of Maine System; University of Maine Orono; Columbia University; Stanford University; Stanford University; University of Alaska System; University of Alaska Fairbanks; Brown University; Imperial College London; Chapman University System; Chapman University; University of Innsbruck; University of Arizona; Virginia Polytechnic Institute & State University; State University of New York (SUNY) System; Stony Brook University
