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• All-sky radio telescopes ditch the dish AI翻译
  作者：Normile, Dennis
• Running out of road AI翻译
  作者：Zhao, Na
  作者单位：Baylor College of Medicine
• De novo design and structure of a peptide-centric TCR mimic binding module AI翻译
  作者：Householder, Karsten D.; Xiang, Xinyu; Jude, Kevin M.; Deng, Arthur; Obenaus, Matthias; Zhao, Yang; Wilson, Steven C.; Chen, Xiaojing; Wang, Nan; Garcia, K. Christopher
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University
  摘要：T cell receptor (TCR) mimics offer a promising platform for tumor-specific targeting of peptide-major histocompatibility complex (pMHC) in cancer immunotherapy. In this study, we designed a de novo alpha-helical TCR mimic (TCRm) specific for the NY-ESO-1 peptide presented by human leukocyte antigen (HLA)-A*02, achieving high on-target specificity with nanomolar affinity (dissociation constant Kd = 9.5 nM). The structure of the TCRm-pMHC complex at 2.05-& Aring; resolution revealed a rigid TCR-...
• EPA begins to dismantle its research office AI翻译
  作者：Stokstad, Erik
• Record-breaking 2023 marine heatwaves AI翻译
  作者：Dong, Tianyun; Zeng, Zhenzhong; Pan, Ming; Wang, Dashan; Chen, Yuntian; Liang, Lili; Yang, Shuai; Jin, Yubin; Luo, Shuxin; Liang, Shijing; Huang, Xiaowen; Zhao, Dongzhi; Ziegler, Alan D.; Chen, Deliang; Li, Laurent Z. X.; Zhou, Tianjun; Zhang, Dongxiao
  作者单位：Eastern Institute of Technology, Ningbo; Southern University of Science & Technology; Southern University of Science & Technology; University of California System; University of California San Diego; Scripps Institution of Oceanography; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Hong Kong Polytechnic University; Nanjing University of Information Science & Technology; Tsinghua University; Sorbonne Universite; Universite PSL; Ecole Normale Superieure (ENS); Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS
  摘要：The year 2023 witnessed an extraordinary surge in marine heatwaves (MHWs) across Earth's oceans, setting new records in duration, extent, and intensity, with MHW activity totaling 53.6 billion degrees C days square kilometer-more than three standard deviations above the historical norm since 1982. Notable events include the North Atlantic MHW (276-year return period) and the Southwest Pacific (141 years). Using ECCO2 (Estimating the Circulation and Climate of the Ocean-Phase II) high-resolutio...
• Europe plans to double flagship funding scheme AI翻译
  作者：O'Grady, Cathleen
• Harnessing insulin biology to treat diabetes and cancer AI翻译
  作者：Solinas, Giovanni
  作者单位：University of Gothenburg
• Design of high-specificity binders for peptide-MHC-I complexes AI翻译
  作者：Liu, Bingxu; Greenwood, Nathan F.; Bonzanini, Julia E.; Motmaen, Amir; Meyerberg, Jeremy; Dao, Tao; Xiang, Xinyu; Ault, Russell; Sharp, Jazmin; Wang, Chunyu; Visani, Gian Marco; Vafeados, Dionne K.; Roullier, Nicole; Nourmohammad, Armita; Scheinberg, David A.; Garcia, K. Christopher; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Memorial Sloan Kettering Cancer Center; Stanford University; Stanford University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Cornell University; Weill Cornell Medicine; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
  摘要：Class I major histocompatibility complex (MHC-I) molecules present peptides derived from intracellular antigens on the cell surface for immune surveillance. Proteins that recognize peptide-MHC-I (pMHCI) complexes with specificity for diseased cells could have considerable therapeutic utility. Specificity requires recognition of outward-facing amino acid residues within the disease-associated peptide as well as avoidance of extensive contacts with ubiquitously expressed MHC. We used RFdiffusion...
• A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors AI翻译
  作者：Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu; Vita, Nicole A.; Dilly, Julien; Kim, Eejung; Maldonato, Benjamin; Seamon, Kyle; Eilerts, Diane F.; Milin, Anthony; Marquez, Abby; Spradlin, Jessica; Helland, Ciara; Gould, Andrea; Ziv, Tamar Bar; Dinh, Phuong; Steele, Shelby L.; Wang, Zhican; Mu, Yunming; Chugh, Seema; Feng, Hanrong; Hennessey, Conner; Wang, Junning; Roth, Jennifer; Rees, Matthew; Ronan, Melissa; Wolpin, Brian M.; Hahn, William C.; Holderfield, Matthew; Wang, Zhengping; Koltun, Elena S.; Singh, Mallika; Gill, Adrian L.; Smith, Jacqueline A. M.; Aguirre, Andrew J.; Jiang, Jingjing; Knox, John E.; Wildes, David
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT)
  摘要：Mutant RAS proteins are among the most prevalent drivers of human cancer, and the glycine to aspartic acid mutation at codon 12 (G12D) is the most common variant. Mutation-selective covalent inhibitors spare RAS in healthy tissue and enable extended pharmacodynamic effect, but covalent targeting of RASG12D is hindered by low nucleophilicity and high proteomic abundance of carboxylic acids. We overcame these challenges with compounds that bind cyclophilin A (CYPA) to create a neomorphic protein...
• Beyond the native repertoire AI翻译
  作者：Hickok, Grant H.; Stromnes, Ingunn M.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities