Proceedings of the National Academy of Sciences of the United States of America

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• Transposon load and RNAi loss synergize to drive intraspecies diversity in Cryptococcus AI翻译
  作者：Iracane, Elise; Buscaino, Alessia
  作者单位：University of Kent
• Little evidence that nonmonogamous family structures are detrimental to children's well-being in Mpimbwe, Tanzania AI翻译
  作者：Minocher, Riana; Mulder, Monique Borgerhoff; Ross, Cody T.
  作者单位：Max Planck Society; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; University of California System; University of California Davis
  摘要：Nuclear family structures are often thought to be essential for the well-being of children. Divorce, the loss of either biological parent, the presence of step-parents, and the practice of polygynous marriage have all been claimed to negatively impact child well-being. However, empirical research on these topics has been limited by the routine use of cross-regional and cross-sectional databases. Cross-regional data render research vulnerable to the ecological inference fallacy, and cross-secti...
• Allee effects limit coral fertilization success AI翻译
  作者：Mumby, Peter J.; Sartori, Greta; Buccheri, Elizabeth; Alessi, Cinzia; Allan, Hannah; Doropoulos, Christopher; Rengiil, Geraldine; Ricardo, Gerard
  作者单位：University of Queensland; Commonwealth Scientific & Industrial Research Organisation (CSIRO)
  摘要：Coral populations are being progressively thinned by climate change, which elevates the risk of reproductive failure from Allee effects during fertilization. Studies have shown that fertilization success improves during more intense and synchronized spawning, but the local dependence of fertilization on coral density remains unknown in wild populations. Here, we measure the fertilization success of individual colonies of the common table coral, Acropora hyacinthus in Palau, Micronesia. We find...
• E93 controls adult differentiation by repressing broad in Drosophila AI翻译
  作者：Cruz, Josefa; Urena, Enric; Iniguez, Luis P.; Irimia, Manuel; Franch-Marro, Xavier; Martin, David
  作者单位：Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Pompeu Fabra University; ICREA; University of London; University College London
  摘要：In Drosophila melanogaster, successful development relies on the precise coordination of both spatial and temporal regulatory axes. The temporal axis governs stage- specific identity and developmental transitions through a number of genes, collectively forming the Metamorphic Gene Network. Among these, Ecdysone inducible protein 93F (E93) serves as the critical determinant for adult specification, but its mechanism of action remains unclear. Here, we found that, rather than acting mainly as an...
• Informing public health protection under new patterns of wildfire smoke AI翻译
  作者：Sacks, Jason D.
  作者单位：United States Environmental Protection Agency
• Specific inhibition of an anticancer target, polo- like kinase 1, by allosterically dismantling its mechanism of substrate recognition (vol 120, e2305037120, 2023) AI翻译
  作者：Park, Jung-Eun; Kirsch, Klara; Lee, Hobin; Oliva, Paola; Ahn, Jong Il; Ravishankar, Harsha; Zeng, Yan; Fox, Stephen D.; Kirby, Samuel A.; Badhwar, Pooja; Andresson, Thorkell; Jacobson, Kenneth A.; Lee, Kyung S.
• Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation AI翻译
  作者：Shen, Chih-hao Howard; Komi, Yusuke; Nakagawa, Yoshiko; Kamatari, Yuji O.; Nomura, Takashi; Kimura, Hiromi; Shida, Toshinobu; Burke, John; Tamai, Shingo; Ishida, Yasuhiro; Tanaka, Motomasa
  作者单位：RIKEN; Institute of Science Tokyo; Gifu University; RIKEN; Gifu University
  摘要：The dynamic balance between formation and disaggregation of amyloid fibrils is associated with many neurodegenerative diseases. Multiple chaperones interact with and disaggregate amyloid fibrils, which impacts amyloid propagation and cellular phenotypes. However, it remains poorly understood whether and how site- specific binding of chaperones to amyloids facilitates the concerted disaggregation process and modulates physiological consequences in vivo. Here, we identified binding sites of Ssa1...
• Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayers AI翻译
  作者：Wiegand, Tina; Liu, Jinghui; Vogeley, Lutz; LuValle-Burke, Isabel; Geisler, Jan; Fritsch, Anatol W.; Hyman, Anthony A.; Grill, Stephan W.
  作者单位：Max Planck Society; Max Planck Society; Technische Universitat Dresden
  摘要：Cortical condensates, transient punctate-like structures rich in actin and the actin nucleation pathway member Neural Wiskott-Aldrich syndrome protein (N-WASP), form during activation of the actin cortex in the Caenorhabditis elegans oocyte. Their emergence and spontaneous dissolution is linked to a phase separation process driven by chemical kinetics. However, the mechanisms that drive the onset of cortical condensate formation near membranes remain unexplored. Here, using a reconstituted pha...
• Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection AI翻译
  作者：Zhang, Yijin; Schmick, Scott D.; Xie, Li; Ghosh, Ujjayini; Weliky, David P.
  作者单位：Wuhan University of Science & Technology; 3M; St Jude Children's Research Hospital; Michigan State University
  摘要：HIV, like other membrane-enveloped viruses, has protein spikes that include a fusion peptide (Fp) segment that binds the host cell membrane and plays a critical role in fusion (joining) viral and cell membranes. The HIV Fp is the similar to 23 N-terminal residues of the gp41 spike protein. Fp adopts intermolecular antiparallel beta sheet structure when lipid fraction cholesterol approximate to 0.3, which is comparable to host cells. Rotational-echo double-resonance NMR was applied to probe the...
• MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells AI翻译
  作者：Mcinerney, Mitchell P.; Awad, Wael; Souter, Michael N. T.; Kang, Yang; Wang, Carl J. H.; Poa, Kean Chan Yew; Abdelaal, Mohamed R.; Le, Ngoc H.; Shepherd, Chloe M.; Mcneice, Conor; Meehan, Lucy J.; Nelson, Adam G.; Raynes, Jeremy M.; Mak, Jeffrey Y. W.; Mccluskey, James; Chen, Zhenjun; Ang, Ching-Seng; Fairlie, David P.; Le Nours, Jerome; Illing, Patricia T.; Rossjohn, Jamie; Purcell, Anthony W.
  作者单位：Monash University; Monash University; University of Melbourne; Peter Doherty Institute; University of Queensland; University of Queensland; University of Melbourne; Cardiff University
  摘要：The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal- associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1- restricted T cells expressing more diverse T cell receptors (TCRs), some with anti- tumor reactivity. However, knowledge of the range of the antigen(s) that can activate diverse MR1- reactive T cells remains incomplete. Here, we identify pyridoxal (vitamin B6) as a naturally...