Proceedings of the National Academy of Sciences of the United States of America

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• The HUSH epigenetic repressor complex silences PML nuclear body- associated HSV-1 quiescent genomes AI翻译
  作者：Roubille, Simon; Escure, Tristan; Juillard, Franceline; Corpet, Armelle; Neplaz, Remi; Binda, Olivier; Seurre, Coline; Gonin, Mathilde; Bloor, Stuart; Cohen, Camille; Texier, Pascale; Haigh, Oscar; Pascual, Olivier; Ganor, Yonatan; Magdinier, Frederique; Labetoulle, Marc; Lehner, Paul J.; Lomonte, Patrick
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Institut Universitaire de France; University of Ottawa; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); CEA; Universite Paris Saclay; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP; Hopital Universitaire Antoine-Beclere - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay
  摘要：Herpes simplex virus 1 (HSV-1) latently infected neurons display diverse patterns in the distribution of the viral genomes within the nucleus. A key pattern involves quiescent HSV-1 genomes sequestered in promyelocytic leukemia nuclear bodies (PML NBs) forming viral DNA- containing PML-NBs (vDCP NBs). Using a cellular model that replicates vDCP NB formation, we previously demonstrated that these viral genomes are chromatinized with the H3.3 histone variant modified on its lysine 9 by trimethyl...
• Lethal COVID-19 associates with RAAS- induced inflammation for multiple organ damage including mediastinal lymph nodes AI翻译
  作者：Topper, Michael J.; Guarnieri, Joseph W.; Haltom, Jeffrey A.; Chadburn, Amy; Cope, Henry; Frere, Justin; An, Julia; Borczuk, Alain; Sinha, Saloni; Kim, Jangkeun; Park, Jiwoon; Butler, Daniel; Meydan, Cem; Foox, Jonathan; Bram, Yaron; Richard, Stephanie A.; Epsi, Nusrat J.; Agan, Brian; Chenoweth, Josh G.; Simons, Mark P.; Tribble, David; Burgess, Timothy; Dalgard, Clifton; Heise, Mark T.; Moorman, Nathaniel J.; Baxter, Victoria K.; Madden, Emily A.; Taft-Benz, Sharon A.; Anderson, Elizabeth J.; Sanders, Wes A.; Dickmander, Rebekah J.; Beigel, Katherine; Widjaja, Gabrielle A.; Janssen, Kevin A.; Lie, Timothy; Murdock, Deborah G.; Angelin, Alessia; Albrecht, Yentli E. Soto; Olali, Arnold Z.; Cen, Zimu; Dybas, Joseph; Priebe, Waldemar; Emmett, Mark R.; Best, Sonja M.; Johnson, Maya Kelsey; Trovao, Nidia S.; Clark, Kevin B.; Zaksas, Victoria; Meller, Robert; Grabham, Peter; Schisler, Jonathan C.; Moraes-Vieira, Pedro M.; Pollett, Simon; Mason, Christopher E.; Wurtele, Eve Syrkin; Taylor, Deanne; Schwartz, Robert E.; Beheshti, Afshin; Wallace, Douglas C.; Baylin, Stephen B.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Cornell University; Weill Cornell Medicine; University of Nottingham; Icahn School of Medicine at Mount Sinai; Cornell University; Weill Cornell Medicine; Uniformed Services University of the Health Sciences - USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; Uniformed Services University of the Health Sciences - USA; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Texas System; University of Texas Medical Branch Galveston; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC); Carnegie Mellon University; University of Chicago; Morehouse School of Medicine; Columbia University; Universidade Estadual de Campinas; Universidade de Sao Paulo; Iowa State University; Iowa State University; Iowa State University; University of Pennsylvania; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Pennsylvania; Van Andel Institute
  摘要：Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS- CoV-2. Subsets of the 100 top- upregulated genes in nasal swabs are upregulated in the heart, lung, kidney, and liver, but not mediastinal lymph nodes. Twenty- two of these are noncanonical immune genes, which we link to components of the renin- angiotensin- activation- system that manifest as increased fibrin deposition, ...
• High energetic cost of color change in octopuses AI翻译
  作者：Sonner, Sofie C.; Onthank, Kirt L.
  摘要：For many animals, color change is a critical adaptive mechanism believed to carry a substantial energetic cost. Yet, no study to date has directly measured the energy expenditure associated with this process. We examined the metabolic cost of color change in octopuses by measuring oxygen consumption in samples of excised octopus skin during periods of chromatophore expansion and contraction and then modeled metabolic demand over the whole octopus as a function of octopus mass. The metabolic de...
• REGγ is essential to maintain bone homeostasis by degrading TRAF6, preventing osteoporosis AI翻译
  作者：Du, Yingying; Chen, Hui; Zhou, Lei; Guo, Qunfeng; Gong, Shuangming; Feng, Siyuan; Guan, Qiujing; Shi, Peilin; Lv, Tongxin; Guo, Yilan; Yang, Cheng; Sun, Peng; Li, Kun; Xu, Shuogui; Li, Lei
  作者单位：East China Normal University; Fudan University; East China Normal University; East China Normal University; Shanghai Jiao Tong University; Naval Medical University; East China Normal University; East China Normal University; Naval Medical University; East China Normal University; East China Normal University
  摘要：Primary osteoporosis, manifesting as decreased bone mass and increased bone fragility, is a silent disease that is often ignored until a bone breaks. Accordingly, it is urgent to develop reliable biomarkers and novel therapeutic strategies for osteoporosis treatment. Here, we identified REG gamma as a potential biomarker of osteoporotic populations through proteomics analysis. Next, we demonstrated that REG gamma deficiency increased osteoclast activity and triggered bone mass loss in REG gamm...
• Structural, biophysical, and biochemical insights into C-S bond cleavage by dimethylsulfone monooxygenase AI翻译
  作者：Gonzalez, Reyaz; Soule, Jess; Phan, Ngan; Wicht, Denyce K.; Dowling, Daniel P.
  作者单位：University of Massachusetts System; University of Massachusetts Boston; Suffolk University; University of California System; University of California Los Angeles; University of California System; University of California Berkeley
  摘要：Sulfur is an essential element for life. Bacteria can obtain sulfur from inorganic sulfate; but in the sulfur starvation-induced response, Pseudomonads employ two- component flavin- dependent monooxygenases (TC- FMOs) from the msu and sfn operons to assimilate sulfur from environmental compounds including alkanesulfonates and dialkylsulfones. Here, we report binding studies of oxidized FMN to enzymes involved within the P. fluorescens enzymatic pathway responsible for converting dimethylsulfon...
• The interplay between liquid-liquid and ferroelectric phase transitions in supercooled water AI翻译
  作者：Izzo, Maria Grazia; Russo, John; Pastore, Giorgio
  作者单位：Universita Ca Foscari Venezia; International School for Advanced Studies (SISSA); Sapienza University Rome; University of Trieste
  摘要：The distinctive characteristics of water, evident in its thermodynamic anomalies, have implications across disciplines from biology to geophysics. Considered a valid hypothesis to rationalize its unique properties, a liquid-liquid phase transition in water below the freezing point, in the so-called supercooled regime, has nowadays been observed in several molecular dynamics simulations and is being actively researched experimentally. The hypothesis of ferroelectric phase transition in supercoo...
• Paleo aridity in the Levant driven by a strong North Atlantic latitudinal surface temperature gradient and present- day relevance AI翻译
  作者：Kushnir, Yochanan; Stein, Mordechai; Biasutti, Michela; Kiro, Yael; Goldsmith, Yonaton; Goldstein, Steven L.
  作者单位：Columbia University; Hebrew University of Jerusalem; Geological Survey Israel; Weizmann Institute of Science; Columbia University
  摘要：The mechanisms underlying the current greenhouse gas (GHG) forced decline in Mediterranean rainfall remain a matter of debate. To inform our understanding of the current and projected drying, we examined extended arid intervals in the late Quaternary, Eastern Mediterranean (EM) Levant indicated by substantial salt deposits in a Dead Sea sediment core covering the past 220 kyr. These arid events occurred during interglacials, when the Earth was at perihelion to the sun in boreal fall and during...
• Future scientific innovation requires the transformative power of philanthropy AI翻译
  作者：Nestor, Michael W.; Cordova, France; Pines, Darryll; Merfeld, Danielle; Griffiths, Jennifer; Mcnutt, Marcia
  作者单位：National Academies of Sciences, Engineering & Medicine; University System of Maryland; University of Maryland College Park
• Reply to Majer et al.: Negotiating policy action for transformation requires both sociopolitical and behavioral perspectives AI翻译
  作者：Patterson, James J.; Feola, Giuseppe; Kim, Rakhyun E.
  作者单位：Utrecht University
• Soft matter mechanics of baseball's Rubbing Mud AI翻译
  作者：Pradeep, Shravan; Chen, Xiangyu; Seiphoori, Ali; Vann, David R.; Arratia, Paulo E.; Jerolmack, Douglas J.
  作者单位：University of Pennsylvania; University of Pennsylvania; Norwegian Geotechnical Institute, NGI
  摘要：Researchers looking for sustainable materials with optimal mechanical properties may draw inspiration from a baseball tradition. For nearly 100 y, a mysterious mud harvested from an undisclosed river site in New Jersey (USA) has been the agent of choice in the USA's Major League Baseball for de-glossing new baseballs. It is unclear, however, what makes this Rubbing Mud work. Here, we perform a multiscale investigation of the rheology and tribology of this mud material under baseball-relevant c...