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作者：Graham, Kristin; Chandrasekaran, Aravind; Wang, Liping; Yang, Noel; Lafer, Eileen M.; Rangamani, Padmini; Stachowiak, Jeanne C.
作者单位：University of Texas System; University of Texas Austin; University of California System; University of California San Diego; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas Austin
摘要：Cellular remodeling of actin networks underlies cell motility during key morphological events, from embryogenesis to metastasis. In these transformations, there is an inherent competition between actin branching and bundling, because steric clashes among branches create a mechanical barrier to bundling. Recently, liquid-like condensates consisting purely of proteins involved in either branching or bundling of the cytoskeleton have been found to catalyze their respective functions. Yet in the c...
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作者：Hueer, Janina; Saxena, Pankhuri; Treue, Stefan
作者单位：Leibniz Association; Deutsches Primatenzentrum (DPZ); Max Planck Society
摘要：Spatial attention represents a powerful top-down influence on sensory responses in primate visual cortical areas. The frontal eye field (FEF) has emerged as a key candidate area for the source of this modulation. However, it is unclear whether the FEF exerts its effects via its direct axonal projections to visual areas or indirectly through other brain areas and whether the FEF affects both the enhancement of attended and the suppression of unattended sensory responses. We used pathway-selecti...
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作者：Puthusseryppady, Vaisakh; Cossio, Daniela; Chrastil, Elizabeth R.
作者单位：University of California System; University of California Irvine
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作者：Fu, Yong; Wang, Bincheng; Wang, Kan; Tang, Xiangyu; Li, Baochang; Yin, Zhiming; Han, Jiaxin; Lin, C. D.; Jin, Cheng
作者单位：Nanjing University of Science & Technology; Kansas State University; Nanjing University of Science & Technology
摘要：High-harmonic generation from a gas target exhibits sharp spectral features and rapid phase variation near the Cooper minimum. By applying spectral filtering, shaped isolated attosecond pulses can be generated where the pulse is split into two in the time domain. Using such shaped extreme-ultraviolet (XUV) pulses, we theoretically study attosecond transient absorption (ATA) spectra of helium 2s2p autoionizing state which is resonantly coupled to the 2s2 dark state by a time-delayed infrared la...
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作者：Tong, Yuquan; Zhang, Peiyuan; Yang, Xueyi; Liu, Xiaohui; Zhang, Jie; Grudniewska, Magda; Jung, Ikrak; Abegg, Daniel; Liu, Jun; Childs-Disney, Jessica L.; Gibaut, Quentin M. R.; Haniff, Hafeez S.; Adibekian, Alexander; Mouradian, M. Maral; Disney, Matthew D.
作者单位：State University System of Florida; University of Florida; Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
摘要：alpha-Synuclein is an important drug target for the treatment of Parkinson's disease (PD), but it is an intrinsically disordered protein lacking typical small-molecule binding pockets. In contrast, the encoding SNCA mRNA has regions of ordered structure in its 5 ' untranslated region (UTR). Here, we present an integrated approach to identify small molecules that bind this structured region and inhibit alpha-synuclein translation. A drug-like, RNA-focused compound collection was studied for bin...
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作者：Vaughan, Timothy G.; Scire, Jeremie; Nadeau, Sarah A.; Stadler, Tanja
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics
摘要：We estimate the basic reproductive number and case counts for 15 distinct Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks, distributed across 11 populations (10 countries and one cruise ship), based solely on phylodynamic analyses of genomic data. Our results indicate that, prior to significant public health interventions, the reproductive numbers for 10 (out of 15) of these outbreaks are similar, with median posterior estimates ranging between 1.4 and 2.8. These estimat...
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作者：Singh, Sneha; Srivastava, Dhiraj; Boyd, Kimberly; Artemyev, Nikolai O.
作者单位：University of Iowa; University of Iowa
摘要：Cone cGMP- phosphodiesterase (PDE6) is the key effector enzyme for daylight vision, and its properties are critical for shaping distinct physiology of cone photoreceptors. We determined the structures of human cone PDE6C in various liganded states by single- particle cryo-EM that reveal essential functional dynamics and adaptations of the enzyme. Our analysis exposed the dynamic nature of PDE6C association with its regulatory gamma- subunit (P gamma) which allows openings of the catalytic pock...
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作者：Langlois, Jill
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作者：Huo, Jing; Xu, Tianqi; Liu, Qi; Polat, Mahiber; Kumar, Sandeep; Zhang, Xiaoqian; Leifer, Andrew M.; Wen, Quan
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作者：Ritz, Nathaniel L.; Brocka, Marta; Butler, Mary I.; Cowan, Caitlin S. M.; Turkington, Christopher J. R.; Draper, Lorraine A.; Bastiaanssen, Thomaz F. S.; Turpin, Valentine; Morales, Lorena; Campos, David; Gheorghe, Cassandra E.; Ratsika, Anna; Sharma, Virat; Golubeva, Anna V.; Aburto, Maria R.; Shkoporov, Andrey N.; Hill, Gerard M. Moloney Colin; Clarke, Gerard; Slattery, David A.; Dinan, Timothy G.; Cryan, John F.
