Proceedings of the National Academy of Sciences of the United States of America

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• Population encoding of observed and actual somatosensations in the human posterior parietal cortex AI翻译
  作者：Chivukula, Srinivas; Aflalo, Tyson; Zhang, Carey; Rosario, Emily R.; Bari, Ausaf; Pouratian, Nader; Andersen, Richard A.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; California Institute of Technology; California Institute of Technology; University of California System; University of California Los Angeles
  摘要：Cognition relies on transforming sensory inputs into a generalizable understanding of the world. Mirror neurons have been proposed to underlie this process, mapping visual representations of others' actions and sensations onto neurons that mediate our own, providing a conduit for understanding. However, this theory has limitations. Here, we hypothesize that mirror- like responses represent one facet of a broader framework in which our brains engage internal models for cognition. We recorded po...
• Energy-poverty-inequality SDGs: A large- scale household analysis and forecasting in China AI翻译
  作者：Li, Cong; Li, Minglai; Zhang, Lin; Li, Qiang; Zheng, Hua; Feldman, Marcus W.
  作者单位：Xi'an Jiaotong University; City University of Hong Kong; City University of Hong Kong; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Stanford University
  摘要：Affordable and clean energy, eliminating poverty, and reducing inequality are important goals of the United Nations Sustainable Development Goals (SDGs). This paper examines the role of access to clean cooking fuels in promoting income growth and reducing income inequality. Using data from Chinese households, we show that a 10% increase in the adoption of clean cooking fuels would result in an increase in total annual household income of US$37 billion nationwide. Income growth from access to c...
• Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability AI翻译
  作者：Wang, Jun; Liao, Long; Miao, Beiping; Yang, Bo; Li, Botai; Ma, Xuhui; Fitz, Annika; Wu, Shanshan; He, Jia; Zhang, Qianqian; Ji, Shuyi; Jin, Guangzhi; Zhang, Jianming; Cao, Ying; Wang, Hui; Qin, Wenxin; Sun, Chong; Bernardsa, Rene; Wang, Cun
  作者单位：Shanghai Jiao Tong University; Helmholtz Association; German Cancer Research Center (DKFZ); Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shanghai Jiao Tong University; Netherlands Cancer Institute; Tongji University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Netherlands Cancer Institute
  摘要：Ferroptosis, a unique form of iron- dependent cell death triggered by lipid peroxidation accumulation, holds great promise for cancer therapy. Despite the crucial role of GPX4 in regulating ferroptosis, our understanding of GPX4 protein regulation remains limited. Through FACS-based genome-wide CRISPR screening, we identified MALT1 as a regulator of GPX4 protein. Inhibition of MALT1 expression enhances GPX4 ubiquitination- mediated degradation by up- regulating the E3 ubiquitin ligase RC3H1. U...
• Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling AI翻译
  作者：Yardeni, Tal; Olali, Arnold Z.; Chen, Hsiao-Wen; Wang, Liqing; Halton, Jeffrey A.; Zenab, Angi; Morrow, Ryan; Butic, Arrienne; Murdock, Deborah G.; Waymire, Katrina G.; Macgregor, Grant R.; Boursi, Ben; Beier, Ulf H.; Hancock, Wayne W.; Wallace, Douglas C.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Chaim Sheba Medical Center; Tel Aviv University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of California System; University of California Irvine; Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University; University of Pennsylvania
  摘要：Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA- cancer association, we analyzed conplastic mice with the C57BL/6J (B6) nucleus but two naturally occurring mtDNA lineages, mtDNAB6 and mtDNANZB, where mtDNANZB mitochondria generate more oxidative phosphorylation (OXPHOS)- derived reactive oxygen species (mROS). In a cardiac transplant model, mtDNAB6Foxp3+ T regulatory (Treg) cells su...
• A first look at rocky exoplanets with JWST AI翻译
  作者：Kreidberg, Laura; Stevenson, Kevin B.
  作者单位：California Institute of Technology; Max Planck Society; Johns Hopkins University
  摘要：Rocky exoplanet characterization has been a top priority for early James Webb Space Telescope (JWST) science operations. Several milestones have been achieved, including the most precise rocky planet transmission spectra measured to date, and the first detection of thermal emission for rocky worlds below 800 K. Despite these advances, no atmospheres have been definitively detected. Several transmission spectra show tentative evidence for molecular absorption features, but these hints are margi...
• A spatially differentiated water pollution policy leads to economic and health inequity AI翻译
  作者：Luo, Zhonghui; Ma, Lala; Xi, Rui; Song, Ran
  作者单位：Hunan University; Kyoto University; University of Kentucky; Resources for the Future; National University of Singapore
  摘要：Disparities in air pollution exposure by socioeconomic status (SES) are well documented. However, there is much less evidence on the inequitable consequences of water pollution and policies affecting water pollution gaps. This study uncovers the distributional impact of China's 11th Five-Year Plan (2006-2010), which triggered spatially differentiated water pollution abatement for a population of almost 1.3 billion. We document that the policy reduced water pollution overall, targeting areas ba...
• The genome of the vining fern Lygodium microphyllum highlights genomic and functional differences between life phases of an invasive plant AI翻译
  作者：Pelosi, Jessie A.; Davenport, Ruth; Kuo, Li- Yaung; Gray, Levi N.; Dant, Anthony J.; Kim, Emily H.; Li, Fay - Wei; Dlugosch, Katrina M.; Krabbenhoft, Trevor J.; Barbazuk, William Bradley; Sessa, Emily B.
  作者单位：State University System of Florida; University of Florida; University of Arizona; National Tsing Hua University; State University of New York (SUNY) System; University at Buffalo, SUNY; State University System of Florida; University of Florida; Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; State University System of Florida; University of Florida; New York Botanical Garden
  摘要：Functional and genomic studies on the differences between the gametophyte and sporophyte life phases of plants remain scarce, yet unraveling these dynamics is crucial to understanding the biology of plants and the success of each phase under different conditions. Here, we provide a reference genome for the highly invasive fern Lygodium microphyllum and compare the transcriptomic and epigenomic landscapes of its gametophyte and sporophyte life phases. Under ambient conditions, we found differen...
• Intention judgments are not a reliable measure of intuitive preferences AI翻译
  作者：Quillien, Tadeg
  作者单位：University of Edinburgh
• DNA- utilization loci enable exogenous DNA metabolism in gut Bacteroidales AI翻译
  作者：Sharan, Deepti; Nurek, Agnieszka; Stemczynski, Joshua; Turan, Kristof; Little, Alexander S.; Coyne, Michael J.; McMillin, Mary; Sidebottom, Ashley M.; Comstock, Laurie E.; Light, Samuel H.
  作者单位：University of Chicago; University of Chicago
  摘要：The human gut microbiome plays a central role in nutrient metabolism, yet the fate of exogenous nucleic acids within this ecosystem remains poorly understood. Here, we show that multiple Bacteroidales species efficiently metabolize exogenous DNA, with Bacteroides thetaiotaomicron converting it into the deaminated nucleobases uracil and xanthine. Using genetic and biochemical approaches, we identify ddbABCDEF, a six-gene locus encoding secreted nucleases and an outer membrane transporter, essen...
• A reanalysis of population dynamics in the Casas Grandes region of Northern Mexico using mitochondrial DNA AI翻译
  作者：Snow, Meradeth; Searcy, Michael T.; Summers, Rachel; Blohm, Tre; Hazelwood, Lacy; McDonald, Holli; Jensen, Samuel J.; Punzo-Diaz, Jose Luis
  作者单位：University of Montana System; University of Montana; Brigham Young University; University of Oklahoma System; University of Oklahoma - Norman
  摘要：The Casas Grandes region in northwest Chihuahua, Mexico, is ideally situated to explore the notion of contact between the US Southwest/Northwest Mexico and Mesoamerica, as it lies geographically in a region where cultural traditions were combined in unique ways. In order to explain these dynamics, past researchers have suggested that the primary catalyst for the flourishing Casas Grandes population in the thirteenth century A.D. was caused by migrants from Mesoamerica or from larger population...