Proceedings of the National Academy of Sciences of the United States of America

最新文章

• GenAI synthetic data create ethical challenges for scientists. Here's how to address them. AI翻译
  作者：Resnik, David B.; Hosseini, Mohammad; Kim, Jeff J. H.; Epiphaniou, Gregory; Maple, Carsten
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Northwestern University; Feinberg School of Medicine; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Warwick
• A proper definition of the paddlewheel effect affirms its existence AI翻译
  作者：Smith, Jeffrey G.; Siegel, Donald J.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
• Boosted recovery of rare earth elements from mining wastes and discarded NdFeB magnets by tributyl phosphate-grafted ZIF-8 AI翻译
  作者：Wan, Shun; Liu, Wu - Jun; Tan, Guangcai; Yu, Han- Qing
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The escalating demand for rare earth elements (REEs) highlights the necessity for their sustainable recovery from waste streams and secondary resources. However, this process requires materials with exceptional selectivity and capacity for REEs due to their low concentration and high presence of interfering ions. Herein, we synthesized zeolitic imidazolate framework- 8 (ZIF-8) and subsequently modified it with tributyl phosphate (TBP) to enhance its affinity and selectivity for the recovery of...
• Quantum tunneling and its absence in deep wells and strong magnetic fields AI翻译
  作者：Fefferman, Charles L.; Shapiro, Jacob; Weinstein, Michael I.
  作者单位：Princeton University; Columbia University; Columbia University
  摘要：We present results on quantum tunneling between deep potential wells, in the presence of a strong constant magnetic field. We construct a family of double-well potentials containing examples for which the low-energy eigenvalue splitting vanishes, and hence quantum tunneling is eliminated. Further, by deforming within this family, the magnetic ground state can be made to transition from symmetric to antisymmetric. However, for typical double wells in a certain regime, tunneling is not suppresse...
• Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction (vol 116, pg 18435, 2019) AI翻译
  作者：Qian, Wei; Kumar, Namrata; Roginskaya, Vera; Fouquerel, Elise; Opresko, Patricia L.; Shiva, Sruti; Watkins, Simon C.; Kolodieznyi, Dmytro; Bruchez, Marcel P.; Van Houten, Bennett
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Carnegie Mellon University
• Fractional magnetic charges and channeling of Faraday lines by disclinations in artificial spin ice AI翻译
  作者：Hurben, Anthony; Hao, Yinchen; Chioar, Ioan- Augustin; Yang, Liu; Strandqvist, Nanny; Saccone, Michael; Bingham, Nicholas S.; Ramberger, Justin; Leighton, Chris; Nisoli, Cristiano; Schiffer, Peter
  作者单位：Yale University; Princeton University; United States Department of Energy (DOE); Los Alamos National Laboratory; United States Department of Energy (DOE); Los Alamos National Laboratory; University of Minnesota System; University of Minnesota Twin Cities
  摘要：We have studied the magnetic moments of artificial spin ice arrays of nanomagnets in both undistorted square arrays and in arrays with a topological defect induced by a single disclination. We confirm that the disclination induces global, macroscopic changes in the low- energy collective states of the nanomagnet moment configuration. Specifically, the disclination leads to Faraday lines of effective magnetic flux that run from the center all the way to the edge of the arrays. Moreover, the geo...
• Impairment of DET1 causes neurological defects and lethality in mice and humans AI翻译
  作者：Karayel, Ozge; Soung, Allison; Gurung, Hem; Schubert, Alexander F.; Klaeger, Susan; Kschonsak, Marc; Al-Maraghi, Aljazi; Bhat, Ajaz A.; Akil, ammira S. Alshabeeb; Dugger, Debra L.; Webster, Joshua D.; French, Dorothy M.; Anand, Dhullipala; Soni, Naharmal; Fakhro, Khalid A.; Rose, Christopher M.; Harris, Seth F.; Ndoja, Ada; Newton, Kim; Dixit, Vishva M.
  作者单位：Roche Holding; Genentech; Roche Holding USA; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Sidra Medical & Research Center; Roche Holding; Roche Holding USA; Genentech; Sidra Medical & Research Center; Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Qatar Foundation (QF); Weill Cornell Medical College Qatar
  摘要：COP1 and DET1 are components of an E3 ubiquitin ligase that is conserved from plants to humans. Mammalian COP1 binds to DET1 and is a substrate adaptor for the CUL4A-DDB1-RBX1 RING E3 ligase. Transcription factor substrates, including c-Jun, ETV4, and ETV5, are targeted for proteasomal degradation to effect rapid transcriptional changes in response to cues such as growth factor deprivation. Here, we link a homozygous DET1(R26W) mutation to lethal developmental abnormalities in humans. Experime...
• A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression AI翻译
  作者：Li, Jiabo; Shih, Ling - Kai; Markwell, Steven M.; Olson, Cheryl L.; Sullivan, David P.; Arvanitis, Constadina; Ross, James L.; Lam, Nicolas G.; Nuszen, Hannah; Hambardzumyan, Dolores; Becher, Oren J.; Brat, Daniel J.
  作者单位：Ann & Robert H. Lurie Children's Hospital of Chicago; Robert H. Lurie Comprehensive Cancer Center; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Emory University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：All glioblastoma (GBM) molecular subsets share the common trait of accelerated progression following necrosis, which cannot be adequately explained by cellular proliferation arising from accumulated genetic alterations. Counter to dogma that cancer outgrows its blood supply, we suggest that development of necrosis is not merely a consequence of aggressive neoplastic growth but could be a contributing force causing tumor microenvironment (TME) restructuring and biologic progression. Mechanisms ...
• Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia AI翻译
  作者：Wang, Jun-Yu; Gui, Tuan-Tuan; Jiao, Bo; Liu, Xuan; Ma, Xiao-Lin; Wang, Cheng; Qiao, Jing; Liu, Wei-Yang; Peng, Li-Jun; Rena, Jia-Yi; Zhua, Yong-Mei; Weng, Xiang-Qin; Wang, Chao; Zhang, Qian-Qian; Song, Gao-Xian; Dai, Yu- Ting; Wang, Zhen-Yi; Lv, Gang; Gao, Chen-Xu; Qiao, Niu; Zhang, Ming; Tan, Yun; Liu, Yuan- Fang; Wang, Sheng-Yue; Hou, Jian; Jing, Duo- Hui; Lyu, An-Kang; Mi, Jian-Qing; Chen, Zhu; Chen, Wen-Lian; Yin, Tong; Fang, Hai; Wang, Jin; Chen, Sai-Juan
  作者单位：Shanghai Jiao Tong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Sciences; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai University of Traditional Chinese Medicine
  摘要：Acute lymphoblastic leukemia (ALL) poses challenges in adult patients, considering its heterogeneous nature and often suboptimal treatment outcomes. Here, we performed a study on 201 newly diagnosed adult ALL cases (age >= 15 y) to generate intracellular and dynamic serum metabolomic profiles. Our findings revealed a predominant increase in bile acid (BA) metabolites in serum, alongside metabolic rewiring that supported highly proliferative states and actively metabolic signaling, such as enri...
• The reuniens thalamus recruits recurrent excitation in the medial prefrontal cortex AI翻译
  作者：Vantomme, Gil; Devienne, Gabrielle; Hull, Jacob M.; Huguenard, John R.
  作者单位：Stanford University
  摘要：The medial prefrontal cortex (mPFC) and hippocampus are critical for memory retrieval, decision making, and emotional regulation. While ventral CA1 (vCA1) shows direct and reciprocal connections with mPFC, dorsal CA1 (dCA1) forms indirect pathways to mPFC, notably via the thalamic reuniens nucleus (Re). Neuroanatomical tracing has documented structural connectivity of this indirect pathway through Re however, its functional operation is largely unexplored. Here, we used in vivo and in vitro el...