Proceedings of the National Academy of Sciences of the United States of America

最新文章

• TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer AI翻译
  作者：Padrao, Nuno; Gregoricchio, Sebastian; Eickhoff, Nils; Dong, Jing; Luzietti, Lara; Bossi, Daniela; Severson, Tesa M.; Siefert, Joseph; Calcinotto, Arianna; Buluwela, Laki; Collier, Maria Donaldson; Ali, Sima; Young, Leoni; Theurillat, Jean-Philippe; Varestija, Damir; Zwart, Wilbert
  作者单位：Netherlands Cancer Institute; Royal College of Surgeons - Ireland; Institute of Oncology Research (IOR); Universita della Svizzera Italiana; Imperial College London; Royal College of Surgeons - Ireland; Beaumont Hospital Dublin
  摘要：While Estrogen receptor alpha (ER alpha)+ breast cancer treatment is considered effective, resistance to endocrine therapy is common. Since ER alpha is still the main driver in most therapy-resistant tumors, alternative therapeutic strategies are needed to disrupt ER alpha transcriptional activity.In this work, we position TRIM24 as a therapeutic target in endocrine resistance, given its role as a key component of the ER alpha transcriptional complex. TRIM24 interacts with ER alpha and other w...
• Plant-specific mitochondrial fission machinery connects mitochondrial dynamics and mitophagosome formation for piecemeal mitophagy AI翻译
  作者：Ma, Juncai; Li, Chaorui; Ren, Kaike; Zhang, Kaiyan; Feng, Lanlan; Law, Kai Ching; Chung, Ka Kit; Bing, Yizhou; Gao, Caiji; Kang, Byung -Ho; Zhuang, Xiaohong
  作者单位：Chinese University of Hong Kong; Chinese University of Hong Kong; South China Normal University; South China Normal University
  摘要：As the energy center of the cell, mitochondria display enormous metabolic plasticity to meet the cellular demand for plant growth and development, which is tightly linked to their structural and dynamic plasticity. Mitochondrial number and morphology are coordinated through the actions of the mitochondrial division and fusion. Meanwhile, damaged mitochondrial contents are removed to avoid excess toxicity to the plant cells. Mitophagy, a selective degradation pathway of mitochondria through a d...
• VPS29C: Adding complexity to the Retromer complex AI翻译
  作者：Chen, Baoyu; Burstein, Ezra; Billadeau, Daniel D.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Mayo Clinic
• Quantitative and sensitive sequencing of somatic mutations induced by a maize transposon AI翻译
  作者：Scherer, Justin; Hinczewski, Michael; Nelms, Brad
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Ohio; Case Western Reserve University; University System of Georgia; University of Georgia
  摘要：Cells accumulate mutations throughout development, contributing to cancer, aging, and evolution. Quantitative data on the abundance of de novo mutations within plants or animals are limited, as new mutations are often rare within a tissue and fall below the limits of current sequencing depths and error rates. Here, we show that mutations induced by the maize Mutator (Mu) transposon can be reliably quantified down to a detection limit of 1 part in 16,000. We measured the abundance of millions o...
• PyReconstruct: A fully open- source, collaborative successor to Reconstruct AI翻译
  作者：Chirillo, Michael A.; Falco, Julian N.; Musslewhite, Michael D.; Lindsey, Larry F.; Harris, Kristen M.
  作者单位：University of Texas System; University of Texas Austin
  摘要：As the serial section community transitions to volume electron microscopy, tools are needed to balance rapid segmentation efforts with documenting the fine detail of structures that support cell function. New annotation applications should be accessible to users and meet the needs of the neuroscience and connectomics communities while also being useful across other disciplines. Issues not currently addressed by a single, modern annotation application include 1) built-in curation systems with u...
• Prevalence of monogamy at the level of flowers in plants AI翻译
  作者：Bawa, Kamaljit S.; Tiwari, Namratha; Shivaprakash, K. Nagaraju
  作者单位：University of Massachusetts System; University of Massachusetts Boston; Nature Conservancy
  摘要：Different types of genomic conflicts are possible in plants with multiovulate ovaries that produce multiseeded fruits: between the maternal plant and its offspring, among developing seeds, between paternal and maternal genomes over seed development, and among paternal parents if different parents sire seeds within an ovary.We tested the hypothesis that such conflicts in multiseeded fruits can be reduced if seeds are sired by a single pollen parent. We conducted a meta-analysis of paternity in ...
• Kinetic pathways of solid-solid phase transitions dictated by short-range interactions AI翻译
  作者：Pan, Hillary; Dshemuchadse, Julia
  作者单位：Cornell University
  摘要：Structural phase transformations allow us to design materials from the ground up. Predicting the structural transformation of crystals during solid-solid phase transitions, however, is challenging, as the transition can proceed through multiple pathways that are difficult to probe experimentally. Using minimal computational models, we show that distinct kinetic pathways between body-centered cubic (bcc) and face-centered cubic (fcc) crystal structures can be encoded into a system by specific p...
• Structure reveals a regulation mechanism of plant outward-rectifying K+ channel CORK by structural rearrangements in the CNBD-Ankyrin bridge AI翻译
  作者：Yamanashi, Taro; Muraoka, Yuki; Furuta, Tadaomi; Kume, Tsukasa; Sekido, Natsuko; Saito, Shunya; Terashima, Shota; Yokoyama, Takeshi; Tanaka, Yoshikazu; Miyamoto, Atsushi; Sato, Kanane; Ito, Tomoyuki; Nakazawa, Hikaru; Umetsu, Mitsuo; Tanudjaja, Ellen; Tsujii, Masaru; Dreyer, Ingo; Schroeder, Julian I.; Ishimaru, Yasuhiro; Uozumi, Nobuyuki
  作者单位：Tohoku University; Tohoku University; Universidad de Talca; University of California System; University of California San Diego
  摘要：Guard cells, which regulate stomatal apertures in plants, possess a sophisticated mechanism for regulating turgor pressure. The outward- rectifying K+out channel GORK, expressed in guard cells of the plant Arabidopsis thaliana, is a central component that promotes stomatal closure by releasing K+ to the extracellular space, thereby lowering turgor pressure. To date, the structural basis underlying the regulation of the K+ transport activity of GORK is unclear. Using cryo- EM, we determined the...
• Political and biological reality checks AI翻译
  作者：Berenbaum, May R.
• Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (Ighm) as a tissue-level aging biomarker AI翻译
  作者：Yin, Fan-Qian; Wang, Xia-Yan; Li, Yong-Xuan; Li, Kai-Jing; Ma, Si-Yu; Lv, Meng-Jiao; Liu, Zhen-Hua; Zhong, Wei-Xia; Liu, Yan; Tang, Chuan-Fang; Liu, Hong-Shi; Li, Yuze; Xiao, Fu-Hui; Kong, Qing-Peng
  作者单位：Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Ningbo University; Chinese Academy of Sciences
  摘要：Identifying aging-associated biomarkers applicable for multiple tissues is challenging but crucial for assessing tissue aging. Here, we obtained and analyzed 456 transcriptomes on 17 organs from 30 C57BL/6 J mice with different ages, revealing the consistently upregulated mRNAs of Ighm, Cob, and Ccl8 in most aged organs. This finding received support from independent transcriptomic and proteomic datasets and was further validated through western blot, enzyme-linked immunosorbent assay (ELISA),...