Proceedings of the National Academy of Sciences of the United States of America

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• HCK regulates NLRP12-mediated PANoptosis AI翻译
  作者：Nadendla, Eswar Kumar; Alluri, Priyanshu; Sundaram, Balamurugan; Kumar, Sivakumar Prasanth; Chadchan, Sangappa B.; Sarkar, Roman; Kanneganti, Thirumala - Devi
  作者单位：St Jude Children's Research Hospital
  摘要：NOD-like receptors (NLRs) are a highly conserved family of cytosolic pattern recognition receptors that drive innate immune responses against pathogens, pathogen-associated molecular patterns, damage-associated molecular patterns, and homeostatic disruptions. Within the NLR family, NLRP12 was recently identified as a key regulator of PANoptosis, which is an innate immune, lytic cell death pathway initiated by innate immune sensors and driven by caspases and RIPKs through PANoptosome complexes....
• The white lupin CCR1 receptor- like kinase controls systemic Autoregulation of Cluster Root and Nodule Development AI翻译
  作者：Marques, Laurence; Divol, Fanchon; Boultif, Alexandra; Garcia, Fanny; Soriano, Alexandre; Maurines- Carboneill, Clea; Fernandez, Virginia; Verstraeten, Inge; Pidon, Helene; Izquierdo, Esther; Hufnagel, Barbara; Peret, Benjamin
  作者单位：Ghent University; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut Agro; INRAE
  摘要：Root development is tightly regulated in plants to optimize nutrient acquisition and interactions with soil microorganisms. In legumes, the Autoregulation of Nodulation (AoN) pathway systemically controls the proliferation of root nodules, which are energy-intensive organs. Mutations affecting the AoN pathway result in a hypernodulation phenotype accompanied by altered root development. However, it remains unclear whether this modification of root development is also systemic and coordinated w...
• Garaizar et al., Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments (vol 121, e2404555121, 2024) AI翻译
  作者：Garaizar, Adiran; Diaz-Oviedo, David; Zablowsky, Nina; Rissanen, Sami; Kobberling, Johannes; Sun, Jiawei; Steiger, Christoph; Steigemann, Patrick; Mann, Florian A.; Meier, Katharina
• Exact and efficient phylodynamic simulation from arbitrarily large populations AI翻译
  作者：Celentano, Michael; Dewitt, William S.; Prillo, Sebastian; Song, Yun S.
  作者单位：University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Many biological studies involve inferring the evolutionary history of a sample of individuals from a large population and interpreting the reconstructed tree. Such an ascertained tree typically represents only a small part of a comprehensive population tree and is distorted by survivorship and sampling biases. Inferring evolutionary parameters from ascertained trees requires modeling both the underlying population dynamics and the ascertainment process. A crucial component of this phylodynamic...
• Dmrt2 and Hmx2 direct intercalated cell diversity in the mammalian kidney through antagonistic and supporting regulatory processes AI翻译
  作者：Parvez, Riana K.; Kim, Doh Kyung; Csipan, Reka L.; Guo, Jinjin; Zeng, Zipeng; Zhang, Chennan C.; Li, Zhongwei; McMahon, Andrew P.
  作者单位：University of Southern California; University of Southern California; California Institute of Technology
  摘要：Intercalated cells (ICs) in the mammalian kidney regulate circulatory pH through IC subtype-restricted actions of bicarbonate transporters: pH is elevated by Slc4a1 restricted to type A-ICs (A-ICs) and depressed by Slc26a4 in type B-IC (B-ICs). NonA-nonB-ICs (nA/nB-ICs) also produce Slc26a4 though their function is unclear. Though both nephron and ureteric progenitor lineages generate A-ICs, the former also generates nA/nB-ICs and the latter B-ICs. Lineage and cell type restricted transporter ...
• Induction of the ISR by AB5 subtilase cytotoxin drives type- I IFN expression in pDCs via STING activation AI翻译
  作者：Barros, Daniela; Ferreira, Beatriz H.; Garcia-Gonzalez, Paulina; Carbone, Francesco; Luka, Marine; Leite-Pinheiro, Fatima; Machado, Mariana D.; Nikolaou, Theopisti; Pilotti, Angelo; Goguet, Eliot; Antas, Paulo; Mendes, Andreia; Zhang, Lichen; Cresci, Marina; Galliot, Lou; Gigan, Julien P.; Reverendo, Marisa; Su, Bing; Narita, Miwako; Paton, Adrienne W.; Paton, James C.; Rocchi, Stephane; Rieux-Laucat, Frederic; Arguello, Rafael J.; Nal, Beatrice; Liang, Yinming; Menager, Mickael; Gatti, Evelina; Almeida, Catarina R.; Pierre, Philippe
  作者单位：Universidade de Aveiro; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Universidade de Aveiro; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Henan Medical University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Niigata University; University of Adelaide; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononuclear cells, concomitant with a proinflammatory response across distinct cell subsets. Notably, SubAB selectively induces type-I interferon (IFN) expression in plasmacytoid dendritic cells, acting synergistically with Toll-like receptor 7 stimulation. The induction of type-I IFN in response to SubAB relies on stimulator of interferon genes (STING) acti...
• Polaronic correlations from optimized ancilla wave functions for the Fermi-Hubbard model AI翻译
  作者：Mueller, Tobias; Thomale, Ronny; Sachdev, Subir; Iqbal, Yasir
  作者单位：University of Wurzburg; University of Zurich; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Harvard University
  摘要：We employ a family of ancilla qubit variational wave functions [Y.-H. Zhang and Sachdev, Phys. Rev. Res. 2, 023172 (2020)] to describe the polaronic correlations the pseudogap metal phase of a hole-doped 2D Fermi-Hubbard model. Comparison to ultracold atom quantum simulator data [J. Koepsell etal., Science 374, 82 (2021)] reveals both qualitative and quantitative agreement with the numerical analysis from half-filling up to 80% hole-doping, capturing the crossover from the polaronic regime to ...
• miR218-5p tips the scales AI翻译
  作者：Diering, Graham H.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
• Monsoon hysteresis reveals atmospheric memory AI翻译
  作者：Katzenberger, Anja; Levermann, Anders
  作者单位：Potsdam Institut fur Klimafolgenforschung; University of Potsdam; Columbia University
  摘要：Within Earth's climate system, the ocean, cryosphere, and vegetation exhibit hysteresis behavior such that their state depends on their past and not merely on their current boundary conditions. The atmosphere's fast mixing time scales were thought to inhibit the necessary memory effect for such multistability. Here, we show that moisture accumulation within the atmospheric column generates hysteresis in monsoon circulation independent of oceanic heat storage and yields two stable atmospheric s...
• De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease AI翻译
  作者：Singh, Ashish K.; Ainciburu, Marina; Wynne, Kieran; Bhat, Sajad A.; Blanco, Alfonso; Tzani, Ioanna; Akiba, Yasutada; Lalor, Stephen J.; Kaunitz, Jonathan; Bourke, Billy; Kelly, Vincent P.; Doherty, Glen A.; Zerbe, Christa S.; Clarke, Colin; Hussey, Seamus; Knaus, Ulla G.
  作者单位：University College Dublin; University College Dublin; University College Dublin; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Greater Los Angeles Healthcare System; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; National Children's Research Centre (NCRC); Trinity College Dublin; University College Dublin; Saint Vincent's University Hospital; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University College Dublin; Royal College of Surgeons - Ireland
  摘要：Infiltrating neutrophils are key effector cells in inflammatory bowel disease (IBD) while providing antimicrobial defense and tissue restitution in the intestine. The complexity of neutrophil functions in local environments underscores our limited understanding of how their adaptation in tissues influences disease progression. Here, we demonstrate that neutrophils recruited in murine colitis and infection models, idiopathic IBD, and gramming, resulting in the emergence of neutrophil population...