Proceedings of the National Academy of Sciences of the United States of America

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• Evolutionarily conserved grammar rules viral factories of amoeba-infecting members of the hyperdiverse Nucleocytoviricota phylum AI翻译
  作者：Rigou, Sofia; Schmitt, Alain; Moreno, Anaisa B.; Lartigue, Audrey; Danner, Lucile; Mayer, Lotte; Giry, Claire; Trabelsi, Feres; Belmudes, Lucid; Olivero-Deibe, Natalia; Le Guenno, Hugo; Coute, Yohann; Berois, Mabel; Legendre, Matthieu; Jeudy, Sandra; Abergel, Chantal; Bisio, Hugo
  作者单位：Aix-Marseille Universite; University of Vienna; CEA; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Pasteur Network; Institut Pasteur de Montevideo; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Universidad de la Republica, Uruguay
  摘要：Despite sharing fewer than 10 core genes, the hyperdiverse Nucleocytoviricota phylum (ranging from poxviruses to giant viruses) universally assembles viral factories (VFs) resembling biomolecular condensates. Regardless, it is unclear how these viruses achieve such a level of functional conservation without clear conserved genetic information. We demonstrate that the VFs produced by amoeba- infecting viruses have liquid- like properties and identify a conserved molecular grammar governing vira...
• DNA2 protein destruction dictates DNA hyperexcision, cGAS- STING activation, and innate immune response in CDK12- deregulated cancers (vol 122,e2413732122,2025) AI翻译
  作者：Sun, Rui; Jiang, Peng; Wang, Zhijun; Yan, Binyuan; Zhu, Shouhai; Huang, Zhenlin; Zhang, Jianong; Ding, Donglin; Li, Xiang; Wang, Liguo; Lou, Zhenkun; Jin, Baiye; Pang, Jun; Huang, Haojie; Xia, Dan
  作者单位：Mayo Clinic
• The US-Israel Blavatnik Scientific Forum on alleviating global water scarcity by desalination and water reuse AI翻译
  作者：Walker, Sharon L.; Dagan, Gedeon; Adin, Avner; Alvarez, Pedro J. J.; Elimelech, Menachem; Radian, Adi
  作者单位：Drexel University; Tel Aviv University; Hebrew University of Jerusalem; Rice University; Rice University; Technion Israel Institute of Technology
• CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis AI翻译
  作者：Yang, Guang; Du, Ximing; Norris, Dougall; Zadoorian, Armella; Zheng, Yuyuan; Gao, Mingming; Brown, Andrew J.; Grey, Shane T.; Zhou, Chun; Yang, Hongyuan
  作者单位：University of New South Wales Sydney; Zhejiang University; Zhejiang University; University of Texas System; University of Texas Health Science Center Houston; George Institute for Global Health; University of New South Wales Sydney
  摘要：The glycerol-3-phosphate (G-3-P) pathway is central to the synthesis of triacylglycerols (TAGs) and glycerophospholipids, essential for membrane biogenesis and lipid storage. The first and rate-limiting step in this pathway is catalyzed by glycerol-3-phosphate acyltransferases (GPATs), with microsomal GPAT3 and GPAT4 being evolutionarily conserved and predominant in most tissues. While previous studies have implicated Calcineurin B homologous protein 1 (CHP1) as a cofactor for GPAT4, the broad...
• FliO is an evolutionarily conserved yet diversified core component of the bacterial flagellar type III secretion system AI翻译
  作者：Andrianova, Ekaterina P.; Dobbins, Amanda L.; Erhardt, Marc; Hendrixson, David R.; Zhulin, Igor B.
  作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Humboldt University of Berlin
  摘要：The bacterial flagellum is a complex nanomachine essential for motility, environmental sensing, and host colonization. While many of its core components have been well characterized, the relevance of proteins such as FliO, which are inconsistently annotated and poorly conserved at the sequence level, has remained ambiguous in their evolutionary and functional status. Here, we present a comprehensive phylogenomic and structural analysis of FliO across >30,000 representative genomes spanning >10...
• Asymmetric development and function of paired sperm- storage organs in Drosophila melanogaster AI翻译
  作者：Chen, Dawn S.; Marrero, Kianairy; Sanchez-Lopez, Javier Arturo; Belenky, Michael; Thomalla, Jonathon M.; Buehner, Norene A.; Apel, Ido; Levi, Yarin; Hafezi, Yassi; Wang, Shuran; Clark, Andrew G.; Heifetz, Yael; Siegal, Mark L.; Wolfner, Mariana F.
  作者单位：Cornell University; New York University; Hebrew University of Jerusalem; University of Pennsylvania
  摘要：Paired structures often have similar forms and functions, but the processes underlying their formation can differ. They may originate from a common source or from parallel sources, or arise from distinct precursors that follow separate developmental pathways, ultimately converging on comparable structures and roles. When asymmetries emerge and persist through development, members of the pair can specialize in ways that might increase fitness. Here, we report that the Drosophila melanogaster fe...
• Amazonian and Andean tree communities are not tracking current climate warming AI翻译
  作者：Farfan-Rios, William; Feeley, Kenneth J.; Myers, Jonathan A.; Tello, Sebastian; Sallo-Bravo, Jhonatan; Malhi, Yadvinder; Phillips, Oliver L.; Baker, Timothy R.; Nina-Quispe, Alex; Garcia-Cabrera, Karina; Saatchi, Sasan S.; Terborgh, John W.; Pitman, Nigel C. A.; Mendoza, Abel Lorenzo Monteagudo; Vasquez, Rodolfo; Salinas, Norma; Cayola, Leslie; Claros, Alfredo Fuentes; Loza, Maria I.; Vargas, Percy Nunez; Silman, Miles R.
  作者单位：Wake Forest University; Wake Forest University; Washington University (WUSTL); University of Miami; Washington University (WUSTL); Missouri Botanical Gardens; Universidad Nacional de San Antonio Abad del Cusco; University of Oxford; University of Leeds; Pontificia Universidad Catolica del Peru; Pontificia Universidad Catolica del Peru; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of California System; University of California Los Angeles; State University System of Florida; University of Florida; James Cook University; Field Museum of Natural History (Chicago); Universidad Mayor de San Andres; University of Missouri System; University of Missouri Saint Louis
  摘要：Climate change is shifting species distributions, leading to changes in community composition and novel species assemblages worldwide. However, the responses of tropical forests to climate change across large-scale environmental gradients remain largely unexplored. Using long-term data over 66,000 trees of more than 2,500 species occurring over 3,500 m elevation along the hyperdiverse Amazon-to-Andes elevational gradients in Peru and Bolivia, we assessed community-level shifts in species compo...
• Aphid herbivory on macrophytes drives adaptive evolution in an aquatic community via indirect effects AI翻译
  作者：Schaefer, Martin; Malacrino, Antonino; Walcher, Christoph; Spaak, Piet; Sarazova, Marie Serwaty -; Kaeser, Silvana; Bulas, Thea; Dambone-Boesch, Christine; Dexter, Eric; Hottinger, Juergen; Boettner, Laura; Vorburger, Christoph; Ebert, Dieter; Xu, Shuqing
  作者单位：Johannes Gutenberg University of Mainz; University of Munster; Clemson University; Universita Mediterranea di Reggio Calabria; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Basel; Johannes Gutenberg University of Mainz
  摘要：Indirect ecological effects occur when the impact of one species on another is mediated by a third species or the shared environment. Although indirect effects are ubiquitous in nature, we know remarkably little about how they may drive ecoevolutionary processes across community boundaries. Here, we show that insect (aphid) herbivory on macrophytes (duckweed) drove the adaptive evolution of a planktonic crustacean (Daphnia magna) in large outdoor aquatic mesocosms via indirect ecological effec...
• Self-generated chemotaxis of mixed cell populations AI翻译
  作者：Ucar, Mehmet Can; Alsberga, Zane; Alanko, Jonna; Sixt, Michael; Hannezo, Edouard
  作者单位：Institute of Science & Technology - Austria; University of Sheffield; University of Turku; Abo Akademi University
  摘要：Cell and tissue movement in development, cancer invasion, and immune response relies on chemical or mechanical guidance cues. In many systems, this behavior is locally directed by self-generated signaling gradients rather than long-range, prepatterned cues. However, how heterogeneous mixtures of cells interact nonreciprocally and navigate through self-generated gradients remains largely unexplored. Here, we introduce a theoretical framework for the self-organized chemotaxis of heterogeneous ce...
• Multisensory feedback makes swimming circuits robust against spinal transection and enables terrestrial crawling in elongate fish AI翻译
  作者：Yasui, Kotaro; Gupta, Astha; Fu, Qiyuan; Suzuki, Shura; Hainer, Jeffrey; Paez, Laura; Lutek, Keegan; Arreguit, Jonathan; Kano, Takeshi; Standen, Emily M.; Ijspeert, Auke J.; Ishiguro, Akio
  作者单位：Tohoku University; Tohoku University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Ottawa; Villanova University; Future University Hakodate
  摘要：Vertebrate locomotion is due to the interplay of neural oscillators and sensory feedback loops in the spinal cord that interact with the body and the environment. Here, we study these circuits with a focus on undulatory locomotion as produced by elongated fish such as eels and lampreys. We address three questions: i) How do proprioception (stretch feedback) and exteroception (pressure on skin) interact with local oscillators to generate stable swimming patterns? ii) Can these feedback loops al...