Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Proximity- activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization AI翻译
  作者：Zhao, Xueqi; Zhao, Yue; Li, Zhu; Liu, Huan; Fu, Wenhao; Chen, Feng; Sun, Ying; Song, Daqian; Fan, Chunhai; Weitz, David; Zhao, Yongxi
  作者单位：Jilin University; Xi'an Jiaotong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Xi'an Jiaotong University; Xi'an Jiaotong University
  摘要：Cellular structure maintenance and function regulation critically depend on the composition and spatial distribution of numerous membrane proteins. However, current methods face limitations in spatial coverage and data scalability, hindering the comprehensive analysis of protein interactions in complex cellular nanoenvironment. Herein, we introduce proximity-activated DNA scanning encoded sequencing (PADSE-seq), an innovative technique that utilizes flexible DNA probes with adjustable lengths....
• Reconciling ecology and evolutionary game theory or When not to think cooperation AI翻译
  作者：Tarnita, Corina E.; Traulsen, Arne
  作者单位：Princeton University; Max Planck Society
  摘要：Evolutionary game theory (EGT)-overwhelmingly employed today for the study of cooperation in various systems, from microbes to cancer and from insect to human societies-started with the seminal 1973 paper by Maynard Smith and Price showing that limited animal conflict can be selected at the individual level. Owing to the explanatory potential of this paper and enabled by the powerful machinery of the soon-to-be-developed replicator dynamics, EGT took off at an accelerated pace and began to sha...
• Manipulation of interoceptive signaling biases decision making in rhesus macaques AI翻译
  作者：Cardenas, Michael A.; Le, Ryan P.; Champ, Tess M.; O'Neill, Derek; Fuglevand, Andrew J.; Gothard, Katalin M.
  作者单位：University of Arizona
  摘要：Several influential theories have proposed that interoceptive signals, sent from the body to the brain, contribute to neural processes that coordinate complex behaviors. We altered the physiological state of the body using compounds that have minimal effect on the brain and evaluated their effect on decision making in rhesus monkeys. We used glycopyrrolate, a nonspecific muscarinic (parasympathetic) antagonist, and isoproterenol, a beta-1/2 (sympathetic) agonist, to create a sympathetic-domina...
• Toward a CRISPR-based mouse model of Vhl- deficient clear cell kidney cancer: Initial experience and lessons learned (vol 121, e2408549121, 2024) AI翻译
  作者：Stransky, Laura A.; Gao, Wenhua; Schmidt, Laura S.; Bi, Kevin; Ricketts, Christopher J.; Ramesh, Vijyendra; James, Amy; Difilippantonio, Simone; Ileva, Lilia; Kalen, Joseph D.; Karim, Baktiar; Jeon, Albert; Morgan, Tamara; Warner, Andrew C.; Turan, Sevilay; Unite, Joanne; Tran, Bao; Choudhari, Sulbha; Zhao, Yongmei; Linn, Douglas E.; Yun, Changhong; Dhandapani, Sripriya; Parab, Vaishali; Pinheiro, Elaine M.; Morris, Nicole; He, Lixia; Vigeant, Sean M.; Pignon, Jean-Christophe; Sticco-Ivins, Maura; Signoretti, Sabina; Van Allen, Eliezer M.; Linehan, W. Marston; Kaelin Jr, William G.
• Laser imaging of ancient tattoos: New tools illuminate established knowledge AI翻译
  作者：Wolf, Aaron Deter-; Robitaille, Benoit; Krutak, Lars
• Genomics highlight an underestimation of phenology sensitivity to the urban heat island effect AI翻译
  作者：Blumstein, Meghan; Webster, Sophie; Hopkins, Robin; Basler, David; Yun, Jie; Des Marais, David Lee
  作者单位：University of Virginia; University of Virginia; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Basel; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research
  摘要：The phenological timing of leaf out in temperate forests is a critical transition point each year that alters the global climate system, which in turn, feeds back to plants, driving leaf out to occur nearly 3 d earlier per decade as temperatures rise. To improve predictions of leaf out timing, urban heat islands (UHIs) or densely developed areas that are hotter than surrounding undeveloped regions are often used to approximate warming via space-for-time substitutions (i.e., rural-to-urban temp...
• Energy landscape analysis of the development of the chromosome structure across the cell cycle AI翻译
  作者：Contessoto, Vinicius G.; Oliveira, Antonio B.; Brahmachari, Sumitabha; Wolynes, Peter G.; Di Pierro, Michele; Onuchic, Jose N.
  作者单位：Rice University; Rice University; Rice University; Rice University; Northeastern University; Northeastern University
  摘要：During mitosis, there are significant structural changes in chromosomes. We used a maximum entropy approach to invert experimental Hi-C data to generate effective energy landscapes for chromosomal structures at different stages during the cell cycle. Modeled mitotic structures show a hierarchical organization of helices of helices. High-periodicity loops span hundreds of kilobases or less, while the other low-periodicity ones are larger in genomic separation, spanning several megabases. The st...
• The TEA domain transcription factors TEAD1 and TEAD3 and WNT signaling determine HLA- G expression in human extravillous trophoblasts AI翻译
  作者：Gu, Bowen; Ferreira, Leonardo M. R.; Herrera, Sebastian; Brown, Lara; Lieberman, Judy; Sherwood, Richard I.; Meissner, Torsten B.; Strominger, Jack L.
  作者单位：Harvard University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School; Medical University of South Carolina; Medical University of South Carolina; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School
  摘要：Maternal-fetal immune tolerance guarantees a successful pregnancy throughout gestation. HLA-G, a nonclassical human leukocyte antigen (HLA) molecule exclusively expressed in extravillous trophoblasts (EVT), is a crucial factor in establishing maternal-fetal immune tolerance by interacting with inhibitory receptors on various maternal immune cells residing in the uterus. While trophoblast-specific cis-regulatory elements impacting HLA-G transcription have been described, the identity of trans-a...
• The antimicrobial activity of ETD151 defensin is dictated by the presence of glycosphingolipids in the targeted organisms (vol 122, e2415524122, 2025) AI翻译
  作者：Kharrat, Ons; Yamaryo-Botte, Yoshiki; Nasreddine, Rouba; Voisin, Sebastien; Aumer, Thomas; Cammue, Bruno P. A.; Madinier, Jean-Baptiste; Knobloch, Thomas; Thevissen, Karin; Nehme, Reine; Aucagne, Vincent; Botte, Cyrille; Bulet, Philippe; Landon, Celine
• Constructed languages are processed by the same brain mechanisms as natural languages AI翻译
  作者：Malik-Moraleda, Saima; Taliaferro, Maya; Shannon, Steve; Jhingan, Niharika; Swords, Sara; Peterson, David J.; Frommer, Paul; Okrand, Marc; Sams, Jessie; Cardwell, Ramsey; Freeman, Cassie; Fedorenko, Evelina
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; University of Southern California
  摘要：What constitutes a language? Natural languages share features with other domains: from math, to music, to gesture. However, the brain mechanisms that process linguistic input are highly specialized, showing little response to diverse nonlinguistic tasks. Here, we examine constructed languages (conlangs) to ask whether they draw on the same neural mechanisms as natural languages or whether they instead pattern with domains like math and programming languages. Using individual-subject fMRI analy...