Proceedings of the National Academy of Sciences of the United States of America

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• Spatial and semantic memory reorganize a hippocampal long-axis gradient AI翻译
  作者：Jordan, Anikka G.; Voss, Joel L.; Kragel, James E.
  作者单位：University of Chicago
  摘要：The hippocampus supports episodic memory by binding spatial and semantic information, yet how this information is simultaneously organized along its long axis remains debated. Gradient accounts propose a continuous shift in representational scale, from coarse coding in anterior to fine coding in posterior regions, whereas modular accounts posit discrete subregions specialized for distinct functions. Using high-resolution fMRI together with eye tracking as a readout of spatial and semantic memo...
• RIPK1 ubiquitination regulates its kinase- independent function in development and inflammation AI翻译
  作者：Li, Ming; Liu, Jianling; Xing, Mingyan; Liu, Han; Wang, Lingxia; Wu, Xiaoxia; Ou, Yangjing; Zhao, Xiaoming; Wang, YangYang; Xie, YangYang; Zhang, Hanwen; Wu, Zhuyang; Hao, Jincheng; Li, Hong; Li, Yu; Zhang, Haibing
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS
  摘要：Receptor-interacting protein kinase 1 (RIPK1) is a key regulator of cell death and inflammation, with its activation modulated by diverse posttranslational modifications. While ubiquitination of RIPK1 at lysine 376 (K376) has been shown to inhibit apoptosis and necroptosis both in vitro and in vivo, its role in inflammation remains undefined. In this study, we introduced a kinase-dead D138N mutation into Ripk1K376R/K376R mice. Notably, Ripk1K376R,D138N/K376R,D138N mice rescued the embryonic le...
• Extended Rice-Thomson analysis and atomistic simulations revealing grain boundary effects on fracture in refractory high-entropy alloys AI翻译
  作者：Wang, Wenqing; Cook, David H.; Chen, Xiaoyu; Kumar, Punit; Minor, Andrew M.; Rao, Satish I.; Asta, Mark; Ritchie, Robert O.; Farkas, Diana
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Virginia Polytechnic Institute & State University
  摘要：Understanding how grain boundaries mediate fracture remains a critical challenge in designing ductile, high-performance refractory alloys. Here, we extend the Rice-Thomson criterion to account for the angle between cracks and the impinging grain boundaries (GBs), capturing the competition between intergranular fracture and dislocation-mediated plasticity. Using machine learning interatomic potentials, we performed molecular statics simulations to probe fracture mechanisms in nanocrystalline Nb...
• Multigenerational and gender-symmetric transmission of migration behaviors in historical Quebec AI翻译
  作者：Cote-Gendreau, Marielle
  作者单位：Princeton University
  摘要：Migration decisions are embedded in social and family trajectories that escape traditional data sources, which tend to observe individuals in isolation. Genealogical microdata now make it possible to trace these dynamics over long time horizons. This paper documents how prior generations' migration histories shape future internal migration behavior, leveraging rich historical microdata spanning over two centuries and multiple generations at the scale of an entire population (Quebec, Canada; 16...
• Chromatin accessibility regulates age-dependent nuclear mechanotransduction AI翻译
  作者：Liao, Yawen; Yuan, Luezhen; Sornapudi, Trinadha Rao; Land, Max; Gupta, Rajshikhar; Shivashankar, G., V
  作者单位：Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; ETH Zurich; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：The integration of environmental cues into cellular programs is crucial for cell function. Yet, how this integration is modulated due to cellular aging remains unclear. We propose that the 3D chromatin organization filters these signals and investigated how age-related chromatin changes in human dermal fibroblasts affect responses to mechanical tension and TGF-beta. Young fibroblasts exhibited synergistic gene expression enhancement in response to combined stimuli, a response that was markedly...
• Local Ras/actin signaling orients individual pseudopods in shallow gradients AI翻译
  作者：van Haastert, Peter J. M.
  作者单位：University of Groningen
• Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion AI翻译
  作者：Pan, Zhaoyi; Zhang, Shujuan; Geng, Xianbo; Wang, Na; Zhang, Lijiang; Wang, Luyao; Yin, Chunhong; Zhang, Huijiao; Liu, Shujun; Zhang, Ling; Fan, Jing; Xue, Guangjian; Li, Rui; Li, Tianle; Yu, Yating; Yao, Hangping; Jin, Changzhong; Wu, Nanping
  作者单位：Jinan Microecological Biomedicine Shandong Laboratory; Hangzhou Medical College; Shandong Center for Disease Prevention & Control; Shandong First Medical University & Shandong Academy of Medical Sciences; Zhejiang University; Collaborative Innovation Center for Diagnosis & Treatment of Infectious Diseases
  摘要：Innate immune evasion is critical for productive viral replication. Activation of the cGAS-STING antiviral signaling pathway and its downstream effector genes plays a pivotal role in restricting viral replication during early DNA virus infection. Through a comprehensive genomic screen of monkeypox virus (MPXV), we identified three viral genes, OPG147, OPG188, and OPG200, whose expression potently suppresses cGAS-STING pathway activation. Notably, the N-terminal domain of the Poxin protein enco...
• Moiré collapse and Luttinger liquids in twisted anisotropic homobilayers AI翻译
  作者：de Sousa, Duarte J. P.; Lee, Seungjun; Guinea, Francisco; Low, Tony
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：We introduce twisted anisotropic homobilayers as a distinct class of moir & eacute; systems, characterized by a distinctive magic angle, theta M, where the moir & eacute; unit cell collapses. Unlike conventional studies of moir & eacute; materials, which primarily focus on small lattice misalignments, we demonstrate that this moir & eacute; collapse occurs at large twist angles in generic twisted anisotropic homobilayers. The collapse angle, theta M, is likely to give rise quasi-crystal behavi...
• Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection AI翻译
  作者：Janova, Hana; Zhao, Fang R.; Akgul, Ali; Schatz, Meredith; Alligood, Daniel M.; Alvarado, David M.; Thackray, Larissa B.; Stappenbeck, Thaddeus S.; Diamond, Michael S.
  作者单位：Washington University (WUSTL); University of Texas System; University of Texas Health Science Center Houston; Washington University (WUSTL); Cleveland Clinic Foundation; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：Functional gastrointestinal (GI) tract disorders affect a substantial proportion of the global population and are often preceded by intestinal infections that cause injury to enteric neurons and glia through unrestrained immune responses. However, the mechanisms that limit infection-induced inflammation and protect the enteric nervous system remain poorly understood. Here, we defined such neuron-glia-macrophage interactions after West Nile virus (WNV) infection; this model neurotropic virus ca...
• A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants AI翻译
  作者：Lavilla-Puerta, Mikel; He, Yuming; Piccinini, Luca; Di Paco, Lorenzo; Papachristodoulou, Antonis; Licausi, Francesco; Giuntoli, Beatrice
  作者单位：Scuola Superiore Sant'Anna; University of Oxford; University of Oxford; University of Pisa
  摘要：Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional adaptive responses to hypoxia are rapidly mounted by Ethylene Response Factors VII (ERFVIIs), regulated by Plant Cysteine Oxidases (PCOs) through the cysteine branch of the N-degron pathway (Cys-NDP) for oxygen sensing. However, this relatively simple regulatory circuit, consisting of both constituti...