Proceedings of the National Academy of Sciences of the United States of America

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• T cell-intrinsic AIM2 exacerbates lung inflammation in OVA-LPS- and HDM-induced asthma models AI翻译
  作者：Chou, Wei-Chun; Hsu, Martin; Wrobel, John A.; Holley-Guthrie, Elizabeth; Jania, Corey M.; Liang, Kaixin; Yang, Shuangshuang; Seller, Rani S.; Hu, Xiaoqing; Schworer, Stephen A.; Livraghi-Butrico, Alessandra; Tilley, Stephen L.; Wan, Yisong Y.; Ting, Jenny P. -Y.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
  摘要：Asthma is a heterogeneous inflammatory airway disease characterized by immune dysregulation, airway hyperresponsiveness (AHR), and excessive immune activation. Although NLRP3 (NOD-like receptor family pyrin domain-containing 3) has been extensively studied in asthma, its role remains controversial, and the contribution of DNA sensor AIM2 (Absent in Melanoma 2) is less well defined. To assess AIM2's relevance in asthma, we analyzed public human datasets and found increased AIM2, but not NLRP3, ...
• Maternal nutrition determines the variable expressivity of STRA6-associated eye malformations AI翻译
  作者：Saadane, Aicha; von Lintig, Johannes
  作者单位：University System of Ohio; Case Western Reserve University
  摘要：Mutations in STRA6, the high-affinity receptor for retinol-binding protein, cause Matthew-Wood syndrome, a congenital disorder characterized by striking phenotypic variability ranging from isolated ocular anomalies to severe multisystem malformations. The mechanisms underlying this variable expressivity and incomplete penetrance remain poorly understood. Here, we used mice to determine how maternal vitamin A status and embryonic Stra6 genotype interact to shape ocular development. Using Stra6-...
• The free-living wellspring of symbiotic nitrogen fixation in Bradyrhizobium AI翻译
  作者：Ling, Lu; Wang, Sishuo; Tao, Jinjin; Pervent, Marjorie; Ho, Kaitlyn E.; Sciallano, Coline; Camuel, Alicia; Nouwen, Nico; Giraud, Eric; Luo, Haiwei
  作者单位：Chinese University of Hong Kong; Chinese University of Hong Kong; Universite de Montpellier; Universite de Montpellier; AgroParisTech; CIRAD; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong
  摘要：The evolutionary origin of nitrogen-fixing symbiosis has been a long-standing question. To address this, we focused on Bradyrhizobium, a globally abundant bacterial genus that includes classic symbiotic lineages, which rely on the common Nod factor signaling pathway to form nodules, and close relatives capable of fixing nitrogen in a free-living state. We isolated 88 strains carrying the key genes for nitrogen fixation (nif) from nonlegume environments and analyzed them alongside 586 public Br...
• HUWE1 targets mitochondria via RMC1 to promote neurodevelopment AI翻译
  作者：Yi, Jiamin; Yang, Qin; Zhou, Chunzhuang; Zhu, Yunfei; Tu, Yingfeng; Zhao, Lin; Tang, Min; Qin, Junhong; Long, Tao; Li, Tianxing; Li, Ping; Gong, Zikang; Wang, Qilin; Yong, Xin; Jia, Da
  作者单位：Sichuan University; Sichuan University
  摘要：The HECT-type E3 ubiquitin ligase HUWE1 is a critical regulator of protein homeostasis, genome stability, and neurodevelopment. Variants in HUWE1 are linked to X-linked intellectual disability (XLID), yet a significant number of HUWE1 variants are noncatalytic, leaving their disease mechanisms unresolved. Here, we identify an AMBRA1-RMC1-HUWE1 signaling axis that directs HUWE1-mediated ubiquitination to mitochondria to regulate neural development. In zebrafish, noncatalytic HUWE1 variants foun...
• Plant pathogenic nematode exosomes remodel vector tracheae to enhance pathogen transmission (vol 123, e2600386123, 2026) AI翻译
  作者：Chang, Yue; Zhou, Jiao; Ye, Fangyuan; Zhang, Hongxia; Sun, Jianghua; Zhao, Lilin
• Reply to Chi et al.: Defining BRCA1P1 as a tumor-intrinsic immunoregulatory axis in breast cancer AI翻译
  作者：Han, Yoo Jane; Olopade, Olufunmilayo I.
  作者单位：University of Chicago; University of Chicago
• Whistleblowers can contain the unethical externalities of human-AI delegation AI翻译
  作者：Purcell, Zoe A.; Kobis, Nils; Samuel, Andrew; Bonnefon, Jean-Francois
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Utrecht University; University of Duisburg Essen; Loyola University Maryland; Communaute d'universites et etablissements de Toulouse (Comue); Universite Toulouse 1 Capitole; Toulouse School of Economics
  摘要：Prior work using controlled principal-agent experiments suggests two risks from delegating tasks to AI systems: Human principals are more likely to request profit-maximizing misconduct from AI agents than from human agents, and AI agents are more likely to comply. Here we test whether third-party observers can contain the resulting harm. In an incentivized die-reporting paradigm, principals instructed either a human or an AI agent how strongly to prioritize profit over accuracy, creating poten...
• Helfrich walls in nematic toroidal droplets in the presence of magnetic fields AI翻译
  作者：Rojo-Gonzalez, Javier; Slaughter, Charlotte G.; Collings, Peter J.; Kikkawa, Jay; Yodh, Arjun G.; Fernandez-Nieves, Alberto
  作者单位：University of Barcelona; University of Barcelona; University of Pennsylvania; ICREA
  摘要：We observe the formation of stable, magnetic field induced, alignment inversion walls, also called Helfrich walls, in nematic liquid crystals (NLCs) confined to a toroidal droplet with tangential anchoring at the boundaries. Walls are rare in NLCs due to their high energy compared to lower-dimensional defect structures. However, we find that Helfrich walls naturally form, transform, and migrate in this unconventional toroidal setting, generating intricate director-field configurations due to t...
• Divergent population trajectories despite similar response to temperature in a widespread aerial insectivore AI翻译
  作者：Taff, Conor C.; Shipley, J. Ryan; Ardia, Daniel R.; Aborn, David; Albert, Lauren; Belisle, Marc; Belmaker, Amos; Berzins, Lisha L.; Blake, Tricia; Bonier, Frances; Brewer, Hannah C.; Butler, Michael W.; Cameron, Kyle; Case, Samuel B.; van Oordt, David Chang; Clark, Robert G.; Clotfelter, Ethan D.; Cox, Amelia R.; Dawson, Russell D.; Derryberry, Elizabeth P.; Bohorquez, Ana M. Diaz; Dunn, Peter O.; Ferretti, Valentina; Forsman, Anna M.; Fuirst, Matthew; Garant, Dany; Garrett, Daniel R.; Gutierrez, Jessica; Hagelin, Julie C.; Hardt, Braelei M.; Harris, Mercy E.; Horton, Kyle; Houle, Carolyne; Houtz, Jennifer L.; Jones, Patricia L.; Jordan, Kimberley C.; Kindel, Amanda S.; Klaver, Robert; Knutie, Sarah A.; Lauck, Katherine S.; Lombardo, Michael P.; Lougheed, Stephen C.; Love, Ashley C.; Mackenzie, Stuart A.; McCarty, John P.; McKellar, Ann E.; Mejia, Nicole; Morrissey, Christy A.; Nahom, Mia L.; Norris, D. Ryan; Para, Lillian M.; Pelletier, Fanie; Porter, Cody K.; Rendell, Wallace B.; Riddell, Eric A.; Rivers, James W.; Robertson, Raleigh J.; Rose, Alexandra; Rosvall, Kimberly A.; Ryan, Thomas A.; Shannon, Ryan P.; Shutler, Dave; Simons, Victoria F.; Stanback, Mark; Tarwater, Corey E.; Thorpe, Patrick A.; Tingley, Morgan W.; Tischer, Christine L.; Tonelli, Benjamin A.; Truan, Melanie L.; Twining, Cornelia W.; Uehling, Jennifer J.; Vleck, Carol; Vlec, David; Watson, Michael L.; Wheelwright, Nathaniel T.; Whittingham, Linda A.; Winkler, David W.; Youngflesh, Casey; Zimmer, Cedric; Vitousek, Maren N.
  作者单位：Cornell University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Tennessee System; University of Tennessee at Chattanooga; Indiana University System; Pennsylvania State System of Higher Education (PASSHE); Indiana University Bloomington; Indiana University of Pennsylvania; University of Sherbrooke; Tel Aviv University; University of Saskatchewan; Queens University - Canada; University of Connecticut; Lafayette College; University of Wyoming; Princeton University; Amherst College; University of Northern British Columbia; University of Tennessee System; University of Tennessee Knoxville; University of Wisconsin System; University of Wisconsin Milwaukee; University of Buenos Aires; Purdue University System; Purdue University; University of California System; University of California Davis; Iowa State University; University of California System; University of California Davis; Grand Valley State University; University System of Ohio; Miami University; University of Nebraska System; University of Nebraska Omaha; University of Guelph; University of Tennessee System; University of Tennessee Knoxville; Hope College; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Oregon State University; University of Colorado System; University of Colorado Boulder; Acadia University; University of California System; University of California Los Angeles; Clemson University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Iowa State University; Pennsylvania State System of Higher Education (PASSHE); West Chester University of Pennsylvania
  摘要：Climate change is shifting when animals breed [C. Parmesan, G. Yohe, Nature 421, 37-42 (2003) and S. J. Thackeray et al., Nature 535, 241-245 (2016)], but it is not clear why some populations keep pace with warming while others fall behind [L. D. Bailey etal., Nat. Commun. 13, 2112 (2022) and J. M. Samplonius etal., Glob. Change Biol. 24, 3780-3790 (2018)]. Differences could arise from variation in sensitivity to temperature [L. D. Bailey et al., Nat. Commun. 13, 2112 (2022)] or constraints on...
• Histone chaperone HIRA regulates adiponectin expression and obesity-associated adipose expansion by facilitating Pol II pause release AI翻译
  作者：Wan, Danyang; Lee, Ji-Eun; Park, Young-Kwon; Xie, Guojia; Maisto, Susanna; Agyapong, Christabelle; Ozato, Keiko; Gavrilova, Oksana; Ge, Kai
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  摘要：Adipose tissue is essential for maintaining glucose and lipid homeostasis in mammals. However, epigenomic mechanisms underlying adipose tissue function remain largely unclear. Here, we identify the histone chaperone HIRA as an epigenomic regulator of adipose tissue function. Adipose tissue-specific knockout of Hira in mice impairs insulin sensitivity and restrains adipose tissue expansion during high-fat diet-induced obesity. Mechanistically, HIRA is required for the expression of Adipoq, enco...