Proceedings of the National Academy of Sciences of the United States of America

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• Dynamic monitoring of antibody drug conjugates targeting TROP2 or HER2 in breast cancer using circulating tumor cells AI翻译
  作者：Mishra, Avanish; Abelman, Rachel O.; Cunneely, Quinn; Putaturo, Victor; Deshpande, Akansha A.; Bell, Remy; Seider, Elizabeth M.; Xu, Katherine H.; Shan, Mythreayi; Kelly, Justin; Huang, Shih-Bo; Rieur, Olivia; Knape, Justine; Gopinathan, Kaustav A.; Kikkeri, Kruthika; Edd, Jon F.; Walsh, John; Dai, Charles S.; Ellisen, Leif W.; Ting, David T.; Nieman, Linda; Toner, Mehmet; Bardia, Aditya; Haber, Daniel A.; Maheswaran, Shyamala
  作者单位：University of California System; UCLA Jonsson Comprehensive Cancer Center; University of California Los Angeles; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
  摘要：Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2 (T-DXd) have demonstrated efficacy in metastatic breast cancer, yet paradoxically, outside of HER2-amplified breast cancers, expression levels of these breast cancer-enriched epitopes in tumor biopsies have not been strongly correlated with clinical response. ...
• Random-with-constraints: Constructing minimal models for high-dimensional biology AI翻译
  作者：Nemenman, Ilya; Mehta, Pankaj
  作者单位：Emory University; Emory University; Emory University; Boston University; Boston University
  摘要：Biologists and physicists have a rich tradition of modeling dynamics of living systems with simple models composed of a few interacting components. Despite the remarkable success of this approach, it remains unclear how to use such finely tuned models to study complex biological systems composed of numerous heterogeneous, interacting components. One possible strategy for taming this biological complexity is to embrace the idea that many biological behaviors we observe are typical and can be mo...
• The diversity of soil parasitic protists shapes ecosystem stability worldwide AI翻译
  作者：Wang, Bing; Chen, Dima; Wang, Shuaifei; Wu, Liji; Wu, Ying; Liu, Shengen; Delgado-Baquerizo, Manuel
  作者单位：Inner Mongolia University; Fujian Agriculture & Forestry University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS)
  摘要：Soil parasitic protists influence the health of plants and soil organisms. Yet, the extent to which these interactions impact the stability of terrestrial ecosystems remains largely unquantified. Here, we utilized two independent global-scale biodiversity surveys available online to investigate the relationship between the taxonomic diversity of parasitic protists and satellite-based time series of ecosystem productivity (i.e., normalized difference vegetation index). We found that soil parasi...
• Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice-Earth interactions in Greenland (vol 122, e2504752122, 2025) AI翻译
  作者：Ajourlou, Parviz; Milne, Glenn A.; Love, Ryan; Afonso, Juan C.; Salajegheh, Farshad; Latychev, Konstantin; Kjeldsen, Kristian K.; Lepipas, Alexis; Martos, Yasmina M.; Woodroffe, Sarah A.
• Bacterial biofilms in calcium oxalate kidney stones: Where do we stand? AI翻译
  作者：Gonzalez Gonzalez, Carlos; Zorzi, Federico; Daudon, Michel; Traxer, Olivier
  作者单位：Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Tenon - APHP; Centre National de la Recherche Scientifique (CNRS); heSam Universite; CNRS - Institute for Engineering & Systems Sciences (INSIS); Conservatoire National Arts & Metiers (CNAM); Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Tenon - APHP
• APOBEC2 deficiency disrupts hematopoietic lineage commitment, resulting in emergence of dual identity lymphocytes in mice and humans AI翻译
  作者：Amro, Elias Moris; Gkougkousis, Christos; Seebass, Joachim Guido; Telioglu, Irem; Bakr, Ali; Lorenzo, Jose Paulo; Abolhassani, Hassan; Altenhofen, Jan; Berntson, Lillemor; Ruf, Sandra; Hammarstrom, Lennart; Pan-Hammarstrom, Qiang; Imbusch, Charles D.; Papavasiliou, F. Nina
  作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Johannes Gutenberg University of Mainz; Helmholtz Association; German Cancer Research Center (DKFZ); Johannes Gutenberg University of Mainz; Helmholtz Association; German Cancer Research Center (DKFZ); Karolinska Institutet; Uppsala University; Helmholtz Association; German Cancer Research Center (DKFZ)
  摘要：APOBEC2 is a well-conserved member of the AID/APOBEC family of cytidine deaminases. Most members of the family catalyze the conversion of cytosine to uracil either in DNA or RNA, thereby acting as DNA mutators and/or RNA editors. APOBEC2 is the only family member that appears to be catalytically inactive. Instead, its ability to bind, but not deaminate DNA, has been co-opted into a transcription-factor-like functionality. APOBEC2 is highly expressed in skeletal muscle, where it functions to pr...
• Partial reconstitution of the prophenoloxidase activation system in Anopheles gambiae AI翻译
  作者：Hou, Chunxiang; Wang, Yang; Jiang, Haobo
  作者单位：Oklahoma State University System; Oklahoma State University - Stillwater
  摘要：Melanization is a central insect immune response to wounding and microbial invasion. It is mediated by a system of serine proteases and their homologs, mostly members of the CLIP subfamily, and leads to prophenoloxidase (proPO) activation and PO-mediated production of cytotoxic compounds and melanin polymers that kill and sequester invading pathogens. In mosquitoes, melanotic encapsulation provides an effective defense against malaria parasites, yet the composition and organization of the unde...
• Simultaneous transformations of view and place coding across reference frames in the macaque brain AI翻译
  作者：Huang, Yan; Liu, Anran; Xu, Xiao; Du, Kechen; Mao, Dun
  作者单位：Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Lin Gang Laboratory
  摘要：Vision enables primates to remotely map their environment using eye movements rather than physical locomotion. While view-related spatial coding is prevalent in the primate hippocampus, its origin and precise relationship to standard place coding remain largely unknown. Leveraging untethered neural recording, motion capture, and wireless eye tracking, we examined view and place coding along the parietal-retrosplenial-hippocampal pathway in macaque monkeys freely exploring an open arena. We ide...
• Polyunsaturated fatty acid-derived lipid mediator patterns determine viral pneumonia severity and risk for critical COVID-19 AI翻译
  作者：Papadaki, Maria; Pavlos, Eleftherios; Dubourdeau, Marc; Bailif, Vincent; Badirou, Kamal; Gely, Clemence A.; Galani, Ioanna-Evdokia; Papelis, Dimitris; Kamperi, Natalia; Triantafyllia, Vasiliki; Siouti, Eleni; Salagianni, Maria; Manioudaki, Maria; Paschalidis, Nikolaos; Vatsellas, Giannis; Koukaki, Evangelia; Rapti, Vasiliki; Thanos, Dimitris; Rovina, Nikoletta; Poulakou, Garyfallia; Cobat, Aurelie; Casanova, Jean-Laurent; Tamvakopoulos, Constantin; Andreakos, Evangelos
  作者单位：Academy of Athens; University of Crete; Academy of Athens; Academy of Athens; Academy of Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; Rockefeller University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Howard Hughes Medical Institute
  摘要：Severe respiratory infections such as COVID-19 are characterized by excessive inflammation leading to the development of pneumonia and acute respiratory distress syndrome. Bioactive lipid mediators (LMs) derived from omega 6 and omega 3 polyunsaturated fatty acids are central to the regulation of inflammation, controlling both its initiation and resolution. Still, their role in viral infections remains underexplored. By employing a holistic approach involving the analysis of white blood cell t...
• Advancing AI negotiations: A large-scale autonomous negotiation competition AI翻译
  作者：Vaccaro, Michelle; Caosun, Michael; Ju, Harang; Aral, Sinan; Curhan, Jared R.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Johns Hopkins University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：We conducted an international AI negotiation competition in which participants designed and refined prompts for AI negotiation agents. We then facilitated over 180,000 negotiations between these agents across multiple scenarios with diverse characteristics and objectives. Our findings revealed that principles from human negotiation theory remain crucial even in AI-AI contexts. Surprisingly, warmth-a traditionally human relationship-building trait-was consistently associated with superior outco...