Proceedings of the National Academy of Sciences of the United States of America

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• Extreme climatic events drive consistent and predictable shifts in soil antibiotic resistance genes AI翻译
  作者：Xu, Guanghui; Fu, Yanmei; Lin, Xiaolong; Huang, Xinrong; Yu, Yong; de Vries, Franciska T.; Rillig, Matthias C.
  作者单位：Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Free University of Berlin; Sun Yat Sen University; Chinese Academy of Sciences; Institute of Urban Environment, CAS; University of Amsterdam
  摘要：Antimicrobial resistance (AMR) is a growing One Health challenge, and as climate warming intensifies extreme events, it remains unclear how these disturbances affect soil antibiotic resistance genes (ARGs). Here we analyzed the data from a controlled experiment using soils from 30 grassland sites across ten European countries, which simulated drought, flooding, freeze-thaw, and heatwaves to explore ARG dynamics. Overall, ARGs exhibited relatively small but highly consistent shifts across treat...
• Cross-species identification of conserved and divergent locomotor kinematic strategies using AutoGaitA AI翻译
  作者：Hosseini, Mahan; Klein, Ines; Wunderle, Veronika; Haustein, Moritz; Semmler, Carolin; Kramer, Ann-Kathrin; Tolve, Marianna; Mardare, Vlad; Galvao, Ana; Kuzu, Taylan D.; Grefkes, Christian; Korotkova, Tatiana; Buschges, Ansgar; Fink, Gereon R.; Weiss, Peter H.; Daun, Silvia; Gatto, Graziana
  作者单位：Helmholtz Association; Julich Research Centre; University of Cologne; University of Cologne; University of Cologne; Goethe University Frankfurt; Goethe University Frankfurt; Goethe University Frankfurt Hospital
  摘要：Distinct behaviors require the nervous system to execute specialized motor programs, each characterized by unique patterns of body muscle coordination. Whether the execution and adaptation of these programs follow conserved principles across species and perturbations remains unclear. To compare motor programs across species, perturbations, and behaviors, we developed the Python toolbox Automated Gait Analysis (AutoGaitA). Using AutoGaitA and inferring from kinematics, we found that locomotor p...
• PLASTID ENVELOPE ION CHANNELS (PEC1/2) link Ca2+ and jasmonic acid signaling in plant cells AI翻译
  作者：Muhlbauer, Susanne; Jaslan, Dawid; Duarte Nunes, Ines F.; Brandt, Benjamin; Wutz, Lena; Mekkaoui, Khansa; Zenker, Sanja; Rehberger, Jakob; Radler, Marlena; Holzner, Lorenz; Tisserant, Constance; Volkner, Carsten; Brautigam, Andrea; Robatzek, Silke; Hause, Bettina; Grimm, Christian; Kunz, Hans-Henning
  作者单位：University of Munich; Leibniz Institut fur Pflanzenbiochemie; University of Bielefeld; University of Bielefeld; University of Munich; University of Oxford
  摘要：Plants constantly encounter adverse environmental interactions. One organelle is particularly specialized in stress signaling and phytohormone synthesis: the plastid. Calcium (Ca2+), a key second messenger, is known to intersect with cellular phytohormone signaling networks. While cytosolic Ca2+ dynamics have been studied extensively, the physiological relevance of stromal Ca2+ transients and the identity of channels mediating rapid Ca2+ flux into plastids remain largely unexplored. In this st...
• Environmental fluctuations explain the universal decay of species-abundance correlations with phylogenetic distance (vol 120, e2217144120, 2023) AI翻译
  作者：Sireci, Matteo; Munoz, Miguel A.; Grilli, Jacopo
• RNA aptamers for sodium and lithium are abundant in mammals AI翻译
  作者：White, Neil; Belem de Andrade, Gabriel; Narunsky, Aya; King, Christopher; Sudarsan, Narasimhan; Breaker, Ronald R.
  作者单位：Yale University; Yale University; Central Michigan University; Worcester Polytechnic Institute
  摘要：Riboswitches are common in the bacterial domain of life where they regulate gene expression in response to binding metabolites, elemental ions, or other small ligands. We used comparative sequence analyses to identify numerous RNA motifs in humans and other mammals that are similar in sequence and structure to bacterial riboswitch aptamers for cationic sodium and lithium. Candidates are found in the mRNA transcripts for similar to 70 genes relevant to ion conductance, neuronal development and ...
• A gut symbiotic filamentous fungus reprograms host metabolism and the microbiota to confer radioprotection AI翻译
  作者：Xiao, Huiwen; Liu, Jia; Zhao, Jiamin; Liu, Xiaojing; Wang, Bin; Zeng, Xiaozhou; Liu, Zhihong; Li, Yuan; Dong, Jiali; Cui, Ming; Liu, Xingzhong
  作者单位：Nankai University; Tianjin University; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Radiation Medicine - CAMS; Peking Union Medical College; Soochow University - China
  摘要：The gut mycobiome is increasingly linked to host physiology, yet functional insights are dominated by yeasts, leaving the roles of filamentous fungi largely unexplored. Here, we identify Mucor racemosus as a gut-resident symbiotic filamentous fungus that establishes intestinal colonization via both hyphal and spore forms. M. racemosus confers radioprotection through an integrated metabolic program coupling direct host support with microbiota-mediated amplification. The fungus produces L-glutam...
• Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis AI翻译
  作者：Tran, Vu L.; Gervais, Adrian; Champeaux, Marie-Mechtilde; de Souza Sampaio, Maria Paula; Abel, Sylvie; Calmont, Isabelle; do Rosario, Mateus Santana; Schidlowski, Laire; Simione, Jordan D.; Alves, Pedro Augusto; Puel, Anne; Bastard, Paul; Abel, Laurent; Prando, Carolina; Franca, Rafael Freitas de Oliveira; de Siqueira, Isadora Cristina; Cabie, Andre; Cobat, Aurelie; Zhang, Shen-Ying; Casanova, Jean-Laurent
  作者单位：Rockefeller University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Martinique; CHU Martinique; Hospital Pequeno Principe; Hospital Pequeno Principe; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Hospital Pequeno Principe; Howard Hughes Medical Institute
  摘要：Chikungunya virus (CHIKV) infection is typically not life threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0 to 89 y, n = 245), 20 patients had CNS infection (aged 17 to 87 y). Autoantibodies neutralizing type I interferons (AAN-I-IFN) were found in 35% of patients (4 male and 3 female, aged 17 to 87 y) with encephalitis (4/15), encephalomyelitis (1/2), or...
• Morphological maturation and circuit integration of adult-born neurons are key to functional recovery after traumatic brain injury AI翻译
  作者：Marien, Valerie; Zandecki, Caroline; Van Houcke, Jolien; Maes, Anouk; Ayana, Rajagopal; Van den Haute, Chris; Gijsbers, Rik; Tognolina, Marialuisa; Arckens, Lutgarde
  作者单位：KU Leuven; KU Leuven; KU Leuven; KU Leuven; KU Leuven; KU Leuven
  摘要：Successful repair after brain injury requires a chain of events, including the generation, migration, and successful integration of adult-born neurons into preexisting circuits. In mammals, the capacity for neuronal regeneration is extremely limited and further declines with age, constraining recovery. Regeneration-competent vertebrates offer a unique opportunity to uncover mechanistic principles of seamless brain repair. We here introduce the African turquoise killifish, a naturally short-liv...
• Power-to-Vitamins or Power-to-Protein: An evaluation of the integrated system at an industrial scale from techno-economic perspectives AI翻译
  作者：Schmitz, Lisa Marie; Ramirez-Morales, Juan E.; Ortiz-Ardila, Andres E.; He, Shan; Duboriz, Ievgen; Usack, Joseph G.; Leger, Dorian; Ivanisevic, Milena; Angenent, Largus T.
  作者单位：Eberhard Karls University of Tubingen; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; Max Planck Society; Aarhus University; Aarhus University; Eberhard Karls University of Tubingen
  摘要：We assessed the economic viability of a two-stage system for producing folate- and protein-enriched yeast biomass using acetate derived from CO2 and renewable electric power at a 1,750 m3 scale. In a Power-to-vitamin system producing a biomass product for partial daily protein intakes, heating for nucleic acids removal is unnecessary. Under these conditions, a CO2 input of 31.3 ktCO2 y-1 yields 12.9 ktproduct y-1 containing 813 kgfolate y-1 and 5.6 ktprotein y-1 (43% of yeast biomass). This pr...
• AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD AI翻译
  作者：Wang, Shuai; Zhao, Sophia; Daniels, Adam; Naaman, Efrat; Gardner, Apolonia; Smith, Lois E. H.; Cepko, Constance L.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
  摘要：Oxidative stress is proposed to be a driver of age-related diseases. Age-related macular degeneration (AMD) is one such disease, where the retinal pigment epithelium (RPE) is affected early in the disease. Vasculature damage also occurs, sometimes preceding RPE damage. To model some aspects of dry AMD, we used the NaIO3 mouse model of oxidative damage. Disruption of the deep retinal vascular plexus, disorganization and death of capillaries within the choriocapillaris, and marked electroretinog...