Temporal dynamics of the multi-omic response to endurance exercise training

• 成果类型: Article
• 署名作者: Amar, David; Gay, Nicole R.; Jean-Beltran, Pierre M.; Bae, Dam; Dasari, Surendra; Dennis, Courtney; Evans, Charles R.; Gaul, David A.; Ilkayeva, Olga; Ivanova, Anna A.; Kachman, Maureen T.; Keshishian, Hasmik; Lanza, Ian R.; Lira, Ana C.; Muehlbauer, Michael J.; Nair, Venugopalan D.; Piehowski, Paul D.; Rooney, Jessica L.; Smith, Kevin S.; Stowe, Cynthia L.; Zhao, Bingqing; Clark, Natalie M.; Jimenez-Morales, David; Lindholm, Malene E.; Many, Gina M.; Sanford, James A.; Smith, Gregory R.; Vetr, Nikolai G.; Zhang, Tiantian; Armenteros, Jose J. Almagro; Avila-Pacheco, Julian; Bararpou, Nasim; Ge, Yongchao; Hou, Zhenxin; Marwaha, Shruti; Presby, David M.; Raja, Archana Natarajan; Savage, Evan M.; Steep, Alec; Sun, Yifei; Wu, Si; Zhen, Jimmy; Bodine, Sue C.; Esser, Karyn A.; Goodyear, Laurie J.; Schenk, Simon; Montgomery, Stephen B.; Fernandez, Facundo M.; Sealfon, Stuart C.; Snyder, Michael P.; Adkins, Joshua N.; Ashley, Euan; Burant, Charles F.; Carr, Steven A.; Clish, Clary B.; Cutter, Gary; Gerszten, Robert E.; Kraus, William E.; Li, Jun Z.; Miller, Michael E.; Nair, K. Sreekumaran; Newgard, Christopher; Ortlund, Eric A.; Qian, Wei-Jun; Tracy, Russell; Wheeler, Matthew T.; Dalton, Karen P.; Hastie, Trevor; Hershman, Steven G.; Samdarshi, Mihir; Teng, Christopher; Tibshirani, Rob; Cornell, Elaine; Gagne, Nicole; May, Sandy; Bouverat, Brian; Leeuwenburgh, Christiaan; Lu, Ching-ju; Pahor, Marco; Hsu, Fang-Chi; Rushing, Scott; Walkup, Michael P.; Nicklas, Barbara; Rejesk, W. Jack; Williams, John P.; Xia, Ashley; Albertson, Brent G.; Barton, Elisabeth R.; Booth, Frank W.; Caputo, Tiziana; Cicha, Michael; De Sousa, Luis Gustavo Oliveira; Farrar, Roger; Hevener, Andrea L.; Hirshman, Michael F.; Jackson, Bailey E.; Ke, Benjamin G.; Kramer, Kyle S.; Lessard, Sarah J.; Makarewicz, Nathan S.; Marshall, Andrea G.; Nigro, Pasquale; Powers, Scott; Ramachandran, Krithika; Recto, R. Scott; Richards, Collyn Z-T.; Thyfault, John; Yan, Zhen; Zang, Chongzhi; Amper, Mary Anne S.; Balci, Ali Tugrul; Chavez, Clarisa; Chikina, Maria; Chiu, Roxanne; Gritsenko, Marina A.; Guevara, Kristy; Hansen, Joshua R.; Hennig, Krista M.; Hung, Chia-Jui; Hutchinson-Bunch, Chelsea; Jin, Christopher A.; Liu, Xueyun; Maner-Smith, Kristal M.; Mani, D. R.; Marjanovic, Nada; Monroe, Matthew E.; Moore, Ronald J.; Moore, Samuel G.; Mundorff, Charles C.; Nachun, Daniel; Nestor, Michael D.; Nudelman, German; Pearce, Cadence; Petyuk, Vladislav A.; Pincas, Hanna; Ramos, Irene; Raskind, Alexander Sasha; Rirak, Stas; Robbins, Jeremy M.; Rubenstein, Aliza B.; Ruf-Zamojski, Frederique; Sagendorf, Tyler J.; Seenarine, Nitish; Soni, Tanu; Uppal, Karan; Vangeti, Sindhu; Vasoya, Mital; Vornholt, Alexandria; Walsh, Martin J.; Yu, Xuechen; Zaslavsky, Elena; Zebarjadi, Navid; Bamman, Marcas; Bergman, Bryan C.; Bessesen, Daniel H.; Buford, Thomas W.; Chambers, Toby L.; Coen, Paul M.; Cooper, Dan; Haddad, Fadia; Gadde, Kishore; Goodpaste, Bret H.; Harris, Melissa; Huffman, Kim M.; Jankowsk, Catherine M.; Johannsen, Neil M.; Kohr, Wendy M.; Kraus, William E.; Lester, Bridget; Melanson, Edward L.; Moreau, Kerrie L.; Musi, Nicolas; Newton, Robert L., Jr.; Radom-Aizik, Shlomit; Ramaker, Megan E.; Rankinen, Tuomo; Rasmussen, Blake B.; Ravussin, Eric; Schauer, Irene E.; Schwartz, Robert S.; Sparks, Lauren M.; Thalacker-Mercer, Anna; Trappe, Scott; Trappe, Todd A.; Volpi, Elena
• 署名单位: Stanford University; Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Iowa; Mayo Clinic; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Michigan System; University of Michigan; University System of Georgia; Georgia Institute of Technology; Duke University; Duke University; Emory University; University of Michigan System; University of Michigan; Mayo Clinic; Icahn School of Medicine at Mount Sinai; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of Vermont; Stanford University; Wake Forest University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Emory University; Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; University of Michigan System; University of Michigan; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Oklahoma Medical Research Foundation; State University System of Florida; University of Florida; University of California System; University of California San Diego; Stanford University; University of Alabama System; University of Alabama Birmingham; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Wake Forest University; Mayo Clinic; Stanford University; Stanford University; State University System of Florida; University of Florida; Wake Forest University; Wake Forest University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); State University System of Florida; University of Florida; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Texas System; University of Texas Austin; University of California System; University of California Los Angeles; University of Virginia; Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Vanderbilt University; Stetson University; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Kansas; University of Kansas Medical Center; University of Virginia; University of Virginia; University of Virginia; University of Virginia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University System of Georgia; Georgia Institute of Technology; Emory University; University of Alabama System; University of Alabama Birmingham; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Alabama System; University of Alabama Birmingham; Ball State University; Adventist Health Services; AdventHealth; University of California System; University of California Irvine; Louisiana State University System; Louisiana State University; Pennington Biomedical Research Center; University of Colorado System; University of Colorado Anschutz Medical Campus; Cedars Sinai Medical Center; Louisiana State University System; Louisiana State University; Pennington Biomedical Research Center; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5482
• DOI: 10.1038/s41586-023-06877-w
• 发表日期: 2024-05-02
• 关键词: physical-activity; skeletal-muscle; all-cause; association; metabolism; mechanisms; kallikrein; mortality

摘要

Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood 1-3 . Here, the Molecular Transducers of Physical Activity Consortium 4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository (https://motrpac-data.org/). Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.