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作者：Ferguson-Smith, Anne C.; Bartolomei, Marisa S.
作者单位：University of Cambridge; University of Pennsylvania
摘要：Some genes carry an 'imprint' on either the maternal or the paternal copy, which determines whether or not that copy is expressed. This 1984 discovery changed how scientists think about gene regulation and inheritance.
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作者：Haldon, John
作者单位：Princeton University
摘要：What lessons can we learn from the factors that govern the resilience of human populations? A large-scale analysis examining ancient societies around the world provides a detailed look at what drives sustainability.
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作者：Lin, Brian; Shah, Viral S.; Chernoff, Chaim; Sun, Jiawei; Shipkovenska, Gergana G.; Vinarsky, Vladimir; Waghray, Avinash; Xu, Jiajie; Leduc, Andrew D.; Hintschich, Constantin A.; Surve, Manalee Vishnu; Xu, Yanxin; Capen, Diane E.; Villoria, Jorge; Dou, Zhixun; Hariri, Lida P.; Rajagopal, Jayaraj
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Tufts University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Northeastern University; University of Regensburg; Harvard University; Harvard University Medical Affiliates; Massachusetts Eye & Ear Infirmary; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Airway hillocks are stratified epithelial structures of unknown function1. Hillocks persist for months and have a unique population of basal stem cells that express genes associated with barrier function and cell adhesion. Hillock basal stem cells continually replenish overlying squamous barrier cells. They exhibit dramatically higher turnover than the abundant, largely quiescent classic pseudostratified airway epithelium. Hillocks resist a remarkably broad spectrum of injuries, including toxi...
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作者：Wasko, Urszula N.; Jiang, Jingjing; Dalton, Tanner C.; Curiel-Garcia, Alvaro; Edwards, A. Cole; Wang, Yingyun; Lee, Bianca; Orlen, Margo; Tian, Sha; Stalnecker, Clint A.; Drizyte-Miller, Kristina; Menard, Marie; Dilly, Julien; Sastra, Stephen A.; Palermo, Carmine F.; Hasselluhn, Marie C.; Decker-Farrell, Amanda R.; Chang, Stephanie; Jiang, Lingyan; Wei, Xing; Yang, Yu C.; Helland, Ciara; Courtney, Haley; Gindin, Yevgeniy; Muonio, Karl; Zhao, Ruiping; Kemp, Samantha B.; Clendenin, Cynthia; Sor, Rina; Vostrejs, William P.; Hibshman, Priya S.; Amparo, Amber M.; Hennessey, Connor; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Brodbeck, Jens; Tomassoni, Lorenzo; Bakir, Basil; Socci, Nicholas D.; Herring, Laura E.; Barker, Natalie K.; Wang, Junning; Cleary, James M.; Wolpin, Brian M.; Chabot, John A.; Kluger, Michael D.; Manji, Gulam A.; Tsai, Kenneth Y.; Sekulic, Miroslav; Lagana, Stephen M.; Califano, Andrea; Quintana, Elsa; Wang, Zhengping; Smith, Jacqueline A. M.; Holderfield, Matthew; Wildes, David; Lowe, Scott W.; Badgley, Michael A.; Aguirre, Andrew J.; Vonderheide, Robert H.; Stanger, Ben Z.; Baslan, Timour; Der, Channing J.; Singh, Mallika; Olive, Kenneth P.
作者单位：NewYork-Presbyterian Hospital; Columbia University; Columbia University; NewYork-Presbyterian Hospital; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; Memorial Sloan Kettering Cancer Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; University of Pennsylvania; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Columbia University; NewYork-Presbyterian Hospital; Memorial Sloan Kettering Cancer Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; NewYork-Presbyterian Hospital; Columbia University; H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer Center & Research Institute; NewYork-Presbyterian Hospital; Columbia University; Johns Hopkins University; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Columbia University; NewYork-Presbyterian Hospital; Chan Zuckerberg Initiative (CZI); Howard Hughes Medical Institute; Memorial Sloan Kettering Cancer Center; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Pennsylvania
摘要：Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human patients with cancer whose tumours are driven by RAS mutations 1,2 . RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS and NRAS, with affinity for both mutant and wild-type variants 3 . More than 90% of cases of human pancreatic ductal adenocarcinoma (PDAC) are driven by activating mutations in KRAS 4 . Here we assessed the therapeutic potential of RMC-7977 in a comprehensiv...
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作者：Kumar, Kaavya Krishna; Wang, Haoqing; Habrian, Chris; Latorraca, Naomi R.; Xu, Jun; O'Brien, Evan S.; Zhang, Chensong; Montabana, Elizabeth; Koehl, Antoine; Marqusee, Susan; Isacoff, Ehud Y.; Kobilka, Brian K.
作者单位：Stanford University; Stanford University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are obligate dimers and possess a large extracellular ligand-binding domain that is linked via a cysteine-rich domain to their 7-transmembrane domain(1). Upon activation, these receptors undergo a large conformational change to transmit the ligand binding signal from the extracellular ligand-binding domain to the G protein-coupling 7-transmembrane domain(2). In this manuscript, we propose a model for a sequ...
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作者：Holderfield, Matthew; Lee, Bianca J.; Jiang, Jingjing; Tomlinson, Aidan; Seamon, Kyle J.; Mira, Alessia; Patrucco, Enrico; Goodhart, Grace; Dilly, Julien; Gindin, Yevgeniy; Dinglasan, Nuntana; Wang, Yingyun; Lai, Lick Pui; Cai, Shurui; Jiang, Lingyan; Nasholm, Nicole; Shifrin, Nataliya; Blaj, Cristina; Shah, Harshit; Evans, James W.; Montazer, Nilufar; Lai, Oliver; Shi, Jade; Ahler, Ethan; Quintana, Elsa; Chang, Stephanie; Salvador, Anthony; Marquez, Abby; Cregg, Jim; Liu, Yang; Milin, Anthony; Chen, Anqi; Ziv, Tamar Bar; Parsons, Dylan; Knox, John E.; Klomp, Jennifer E.; Roth, Jennifer; Rees, Matthew; Ronan, Melissa; Cuevas-Navarro, Antonio; Hu, Feng; Lito, Piro; Santamaria, David; Aguirre, Andrew J.; Waters, Andrew M.; Der, Channing J.; Ambrogio, Chiara; Wang, Zhengping; Gill, Adrian L.; Koltun, Elena S.; Smith, Jacqueline A. M.; Wildes, David; Singh, Mallika
作者单位：University of Turin; University System of Ohio; University of Cincinnati; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; University of Salamanca; Consejo Superior de Investigaciones Cientificas (CSIC); Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of North Carolina; University of North Carolina Chapel Hill; University System of Ohio; University of Cincinnati
摘要：RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 61(1). Small molecule inhibitors of the KRAS(G12C) oncoprotein have demonstrated clinical efficacy in patients with multiple cancer types and have led to regulatory approvals for the treatment of non-small cell lung cancer(2,3). Nevertheless, KRAS(G12C) mutations account for only around 15% of KRAS-mutated cancers(4,5), a...
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作者：Spikes, Michael A.
作者单位：Northwestern University
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作者：Vaidyanathan, Gayathri
摘要：The Sumatran orangutan used a plant known to humans for its medicinal qualities.
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作者：Liu, Ao; Kim, Yong-Sung; Kim, Min Gyu; Reo, Youjin; Zou, Taoyu; Choi, Taesu; Bai, Sai; Zhu, Huihui; Noh, Yong-Young
作者单位：University of Electronic Science & Technology of China; Pohang University of Science & Technology (POSTECH); Northwestern University; Korea Research Institute of Standards & Science (KRISS); University of Science & Technology (UST); Pohang University of Science & Technology (POSTECH); University of Electronic Science & Technology of China
摘要：Compared to polycrystalline semiconductors, amorphous semiconductors offer inherent cost-effective, simple and uniform manufacturing. Traditional amorphous hydrogenated Si falls short in electrical properties, necessitating the exploration of new materials. The creation of high-mobility amorphous n-type metal oxides, such as a-InGaZnO (ref. 1), and their integration into thin-film transistors (TFTs) have propelled advancements in modern large-area electronics and new-generation displays(2-8). ...
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作者：Callaway, Ewen
摘要：Latest version of the AI models how proteins interact with other molecules - but DeepMind restricts access to the tool.
