Nature

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• Real-world success stories can boost global plastics treaty AI翻译
  作者：Yu, Haoxuan; Zahidi, Izni
  作者单位：Monash University; Monash University Malaysia
• Sleep pressure modulates single-neuron synapse number in zebrafish AI翻译
  作者：Suppermpool, Anya; Lyons, Declan G.; Broom, Elizabeth; Rihel, Jason
  作者单位：University of London; University College London; University of London; University College London
  摘要：Sleep is a nearly universal behaviour with unclear functions 1 . The synaptic homeostasis hypothesis proposes that sleep is required to renormalize the increases in synaptic number and strength that occur during wakefulness 2 . Some studies examining either large neuronal populations 3 or small patches of dendrites 4 have found evidence consistent with the synaptic homeostasis hypothesis, but whether sleep merely functions as a permissive state or actively promotes synaptic downregulation at t...
• Therapy can combat loneliness, too AI翻译
  作者：Weissman, Myrna M.; Mootz, Jennifer J.
  作者单位：Columbia University
• Refining the impact of genetic evidence on clinical success AI翻译
  作者：Minikel, Eric Vallabh; Painter, Jeffery L.; Dong, Coco Chengliang; Nelson, Matthew R.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; GlaxoSmithKline; Glaxosmithkline USA
  摘要：The cost of drug discovery and development is driven primarily by failure(1), with only about 10% of clinical programmes eventually receiving approval(2-4). We previously estimated that human genetic evidence doubles the success rate from clinical development to approval(5). In this study we leverage the growth in genetic evidence over the past decade to better understand the characteristics that distinguish clinical success and failure. We estimate the probability of success for drug mechanis...
• Lethal AI weapons are here: how can we control them? AI翻译
  作者：Adam, David
  摘要：Autonomous weapons guided by artificial intelligence are already in use. Researchers, legal experts and ethicists are struggling with what should be allowed on the battlefield.
• GIVE IT A WHORL: THE EVOLUTION OF THE CAULIFLOWER'S HEAD AI翻译
  作者：[Anonymous]
• How men evolved to care for babies - before society got in the way AI翻译
  作者：Anderson, Kermyt G.
  作者单位：University of Oklahoma System; University of Oklahoma - Norman
  摘要：An exploration of the evolution of male nurturing shows why, unlike fathers among other great apes, human dads are biologically wired to be hands-on parents.
• Control of neuronal excitation-inhibition balance by BMP-SMAD1 signalling AI翻译
  作者：Okur, Zeynep; Schlauri, Nadia; Bitsikas, Vassilis; Panopoulou, Myrto; Ortiz, Raul; Schwaiger, Michaela; Karmakar, Kajari; Schreiner, Dietmar; Scheiffele, Peter
  作者单位：University of Basel; Swiss Institute of Bioinformatics; Friedrich Miescher Institute for Biomedical Research; University of Basel; Roche Holding
  摘要：Throughout life, neuronal networks in the mammalian neocortex maintain a balance of excitation and inhibition, which is essential for neuronal computation 1,2 . Deviations from a balanced state have been linked to neurodevelopmental disorders, and severe disruptions result in epilepsy 3-5 . To maintain balance, neuronal microcircuits composed of excitatory and inhibitory neurons sense alterations in neural activity and adjust neuronal connectivity and function. Here we identify a signalling pa...
• HOSTILE TAKEOVER: NEST-GRABBING BIRD PICKS OFF CHICKS AI翻译
  作者：[Anonymous]
• Inequality is bad - but that doesn't mean the rich are AI翻译
  作者：Ekelund, Henrik
  摘要：Letter to the Editor