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• Transcranial volumetric imaging using a conformal ultrasound patch AI翻译
  作者：Zhou, Sai; Gao, Xiaoxiang; Park, Geonho; Yang, Xinyi; Qi, Baiyan; Lin, Muyang; Huang, Hao; Bian, Yizhou; Hu, Hongjie; Chen, Xiangjun; Wu, Ray S.; Liu, Boyu; Yue, Wentong; Lu, Chengchangfeng; Wang, Ruotao; Bheemreddy, Pranavi; Qin, Siyu; Lam, Arthur; Wear, Keith A.; Andre, Michael; Kistler, Erik B.; Newell, David W.; Xu, Sheng
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; US Food & Drug Administration (FDA); University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Accurate and continuous monitoring of cerebral blood flow is valuable for clinical neurocritical care and fundamental neurovascular research. Transcranial Doppler (TCD) ultrasonography is a widely used non-invasive method for evaluating cerebral blood flow(1), but the conventional rigid design severely limits the measurement accuracy of the complex three-dimensional (3D) vascular networks and the practicality for prolonged recording(2). Here we report a conformal ultrasound patch for hands-fre...
• TWO BECOME ONE: MERGER MODELS BRAIN MEMBRANE AI翻译
  作者：[Anonymous]
• Frequent disturbances enhanced the resilience of past human populations AI翻译
  作者：Riris, Philip; Silva, Fabio; Crema, Enrico; Palmisano, Alessio; Robinson, Erick; Siegel, Peter E.; French, Jennifer C.; Jorgensen, Erlend Kirkeng; Maezumi, Shira Yoshi; Solheim, Steinar; Bates, Jennifer; Davies, Benjamin; Oh, Yongje; Ren, Xiaolin
  作者单位：Bournemouth University; University of Cambridge; University of Turin; Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; Arizona State University; Arizona State University-Tempe; Montclair State University; University of Liverpool; Max Planck Society; University of Oslo; Seoul National University (SNU); Tufts University; Chinese Academy of Sciences; Institute for the History of Natural Science, CAS
  摘要：The record of past human adaptations provides crucial lessons for guiding responses to crises in the future 1-3 . To date, there have been no systematic global comparisons of humans' ability to absorb and recover from disturbances through time 4,5 . Here we synthesized resilience across a broad sample of prehistoric population time-frequency data, spanning 30,000 years of human history. Cross-sectional and longitudinal analyses of population decline show that frequent disturbances enhance a po...
• Obituary Diana Wall (1943-2024) Ecologist who foresaw the importance of soil biodiversity for the planet AI翻译
  作者：Bardgett, Richard D.
  作者单位：University of Manchester
• How religious scientists balance work and faith AI翻译
  作者：Conlon, Anne Marie
  摘要：Researchers find ways to interweave faith and science, from discussing Ramadan fasts with colleagues to applying religious parables to lab work.
• Complete biosynthesis of QS-21 in engineered yeast AI翻译
  作者：Liu, Yuzhong; Zhao, Xixi; Gan, Fei; Chen, Xiaoyue; Deng, Kai; Crowe, Samantha A.; Hudson, Graham A.; Belcher, Michael S.; Schmidt, Matthias; Astolfi, Maria C. T.; Kosina, Suzanne M.; Pang, Bo; Shao, Minglong; Yin, Jing; Sirirungruang, Sasilada; Iavarone, Anthony T.; Reed, James; Martin, Laetitia B. B.; El-Demerdash, Amr; Kikuchi, Shingo; Misra, Rajesh Chandra; Liang, Xiaomeng; Cronce, Michael J.; Chen, Xiulai; Zhan, Chunjun; Kakumanu, Ramu; Baidoo, Edward E. K.; Chen, Yan; Petzold, Christopher J.; Northen, Trent R.; Osbourn, Anne; Scheller, Henrik; Keasling, Jay D.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Joint BioEnergy Institute - JBEI; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Sandia National Laboratories; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Suranaree University of Technology; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Egyptian Knowledge Bank (EKB); Mansoura University; Technical University of Denmark
  摘要：QS-21 is a potent vaccine adjuvant and remains the only saponin-based adjuvant that has been clinically approved for use in humans(1,2). However, owing to the complex structure of QS-21, its availability is limited. Today, the supply depends on laborious extraction from the Chilean soapbark tree or on low-yielding total chemical synthesis(3,4). Here we demonstrate the complete biosynthesis of QS-21 and its precursors, as well as structural derivatives, in engineered yeast strains. The successf...
• Computationally restoring the potency of a clinical antibody against Omicron AI翻译
  作者：Desautels, Thomas A.; Arrildt, Kathryn T.; Zemla, Adam T.; Lau, Edmond Y.; Zhu, Fangqiang; Ricci, Dante; Cronin, Stephanie; Zost, Seth J.; Binshtein, Elad; Scheaffer, Suzanne M.; Dadonaite, Bernadeta; Petersen, Brenden K.; Engdahl, Taylor B.; Chen, Elaine; Handal, Laura S.; Hall, Lynn; Goforth, John W.; Vashchenko, Denis; Nguyen, Sam; Weilhammer, Dina R.; Lo, Jacky Kai-Yin; Rubinfeld, Bonnee; Saada, Edwin A.; Weisenberger, Tracy; Lee, Tek-Hyung; Whitener, Bradley; Case, James B.; Ladd, Alexander; Silva, Mary S.; Haluska, Rebecca M.; Grzesiak, Emilia A.; Earnhart, Christopher G.; Hopkins, Svetlana; Bates, Thomas W.; Thackray, Larissa B.; Segelke, Brent W.; Lillo, Antonietta Maria; Sundaram, Shivshankar; Bloom, Jesse D.; Diamond, Michael S.; Crowe, James E., Jr.; Carnahan, Robert H.; Faissol, Daniel M.; Lyon, Emily Z. Alipio; Anderson, Penelope S.; Avila-Herrera, Aram; Bennett, William F.; Bourguet, Feliza A.; Chen, Julian C.; Coleman, Matthew A.; Collette, Nicole M.; Davis, Anastasiia; Vannest, Byron D.; Fong, Erika J.; Gilmore, Sean; Goncalves, Andre R.; Hall, Sara B.; Harmon, Brooke; He, Wei; Hoang-Phou, Steven A.; Landajuela, Mikel; Laurence, Ted A.; Lee, Tek Hyung; Da Silva, Felipe Leno; Liu, Chao; Mundhenk, Terrel N.; Mohagheghi, Mariam V.; McIlroy, Peter R.; Le Thanh Mai Pham; Sanchez, Joseph C.; Sinha, Anupama; Solomon, Emilia A.; Watkins, Nicholas; Yang, Jiachen; Ye, Congwang; Zhang, Boya
  作者单位：United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Vanderbilt University; Washington University (WUSTL); Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Defense; United States Department of Energy (DOE); Los Alamos National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Howard Hughes Medical Institute; Washington University (WUSTL); Washington University (WUSTL); Vanderbilt University; Alphabet Inc.; Google Incorporated; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Sandia National Laboratories; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; United States Department of Energy (DOE); Sandia National Laboratories
  摘要：The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs(1-3) and revealed how quickly viral escape can curtail effective options(4,5). When the SARS-CoV-2 Omicron variant emerged in 2021, many antibody drug products lost potency, including Evusheld and its constituent, cilgavimab(4-6). Cilgavimab, like its progenitor COV2-2130, is a class 3 antibody that is compatible with other antibodies in combination(4) and is challenging to replace wit...
• High carrier mobility along the [111] orientation in Cu2O photoelectrodes (vol 628, pg 765, 2024) AI翻译
  作者：Pan, Linfeng; Dai, Linjie; Burton, Oliver J.; Chen, Lu; Andrei, Virgil; Zhang, Youcheng; Ren, Dan; Cheng, Jinshui; Wu, Linxiao; Frohna, Kyle; Abfalterer, Anna; Yang, Terry Chien-Jen; Niu, Wenzhe; Xia, Meng; Hofmann, Stephan; Dyson, Paul J.; Reisner, Erwin; Sirringhaus, Henning; Luo, Jingshan; Hagfeldt, Anders; Graetzel, Michael; Stranks, Samuel D.
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Nankai University; Uppsala University
• Global sites for mutations of unknown origins AI翻译
  作者：Franco, Irene; Supek, Fran
  作者单位：Vita-Salute San Raffaele University; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Copenhagen; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona
  摘要：Genetic sequencing of human kidney cancers worldwide has revealed associations between geographical locations and specific mutation patterns, indicating exposure to known and unknown mutation-promoting agents.
• Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase (Expression of Concern of Vol 415, Pg 339, 2002) AI翻译
  作者：Minokoshi, Yasuhiko; Kim, Young-Bum; Peroni, Odile D.; Fryer, Lee G. D.; Mueller, Corinna; Carling, David; Kahn, Barbara B.
  作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard Medical School; Imperial College London