The phenomenon of genomic imprinting was discovered 40 years ago

• 成果类型: Editorial Material
• 署名作者: Ferguson-Smith, Anne C.; Bartolomei, Marisa S.
• 署名单位: University of Cambridge; University of Pennsylvania
• 刊物名称: Nature
• ISSN/ISSBN: 0028-6491
• DOI: 10.1038/d41586-024-01338-4
• 发表日期: 2024-05-23
• 页码: 763-765
• 关键词: mouse; gene

摘要

Some genes carry an 'imprint' on either the maternal or the paternal copy, which determines whether or not that copy is expressed. This 1984 discovery changed how scientists think about gene regulation and inheritance.