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作者:Wong, Carissa
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作者:Giri, Bapun; Kinsky, Nathaniel; Kaya, Utku; Maboudi, Kourosh; Abel, Ted; Diba, Kamran
作者单位:University of Michigan System; University of Michigan; University of Wisconsin System; University of Wisconsin Milwaukee; University of Iowa; University of Michigan System; University of Michigan
摘要:Memories benefit from sleep(1), and the reactivation and replay of waking experiences during hippocampal sharp-wave ripples (SWRs) are considered to be crucial for this process(2). However, little is known about how these patterns are impacted by sleep loss. Here we recorded CA1 neuronal activity over 12 h in rats across maze exploration, sleep and sleep deprivation, followed by recovery sleep. We found that SWRs showed sustained or higher rates during sleep deprivation but with lower power an...
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作者:Tenzer, Helene; Feuerriegel, Stefan; Piekkari, Rebecca
作者单位:University of Munich; Aalto University
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作者:Kawamura, Kenji; Oyabu, Ikumi
作者单位:Research Organization of Information & Systems (ROIS); National Institute of Polar Research (NIPR) - Japan
摘要:In June 2004, the results of an ambitious Antarctic ice-drilling project brought insight into hundreds of thousands of years of climatic changes. The extraordinary sample still has much to offer climate research - even as its successor is being drilled.
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作者:Bravo, Jack P. K.; Ramos, Delisa A.; Fregoso Ocampo, Rodrigo; Ingram, Caiden; Taylor, David W.
作者单位:University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Institute of Science & Technology - Austria
摘要:Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA degradation1. Here we reveal the activation pathway of the DNA defence module DdmDE system, which rapidly eliminates small, multicopy plasmids from the Vibrio cholerae seventh pandemic strain (7PET)2. Through a combination of cryo-electron microscopy, biochemistry ...
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作者:Wang, Chonghe; Zhao, Xuanhe
作者单位:Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要:Full-body, continuous wearable ultrasound will benefit health care and biomedical research. Seven key obstacles must first be overcome.
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作者:Liang, Chieh-Yu; Raju, Saravanan; Liu, Zhuoming; Li, Yuhao; Arunkumar, Guha Asthagiri; Case, James Brett; Scheaffer, Suzanne M.; Zost, Seth J.; Acreman, Cory M.; Gagne, Matthew; Andrew, Shayne F.; dos Anjos, Deborah Carolina Carvalho; Foulds, Kathryn E.; McLellan, Jason S.; Crowe Jr, James E.; Douek, Daniel C.; Whelan, Sean P. J.; Elbashir, Sayda M.; Edwards, Darin K.; Diamond, Michael S.
作者单位:Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Vanderbilt University; Vanderbilt University; University of Texas System; University of Texas Austin; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Vanderbilt University; Washington University (WUSTL); Washington University (WUSTL)
摘要:Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination1,2. The effects of immune imprinting on serum antibody responses after boosting with variant-matched SARS-CoV-2 vaccines remain uncertain. Here we characterized the serum antibody responses after mRNA vaccine boosting of mice and human clinical trial participants. In mice, a single dose of a preclinical version of mRNA-1273 vaccine encoding Wuhan-1 spike protein min...
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作者:Babatunde, Abdulhammed Opeyemi; Aborode, Abdullahi Tunde; Olayemi, Oladapo O.
作者单位:University of Ibadan
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作者:[Anonymous]
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作者:[Anonymous]
摘要:Textile keeps its cool even when surrounded by urban surfaces that absorb and release heat.