Sleep loss diminishes hippocampal reactivation and replay

• 成果类型: Article
• 署名作者: Giri, Bapun; Kinsky, Nathaniel; Kaya, Utku; Maboudi, Kourosh; Abel, Ted; Diba, Kamran
• 署名单位: University of Michigan System; University of Michigan; University of Wisconsin System; University of Wisconsin Milwaukee; University of Iowa; University of Michigan System; University of Michigan
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5685
• DOI: 10.1038/s41586-024-07538-2
• 发表日期: 2024-06-27
• 页码: 935-+
• 关键词: sharp-wave ripples; synaptic plasticity; place cells; patterns; deprivation; memory; consolidation; interneurons; oscillations; homeostasis

摘要

Memories benefit from sleep(1), and the reactivation and replay of waking experiences during hippocampal sharp-wave ripples (SWRs) are considered to be crucial for this process(2). However, little is known about how these patterns are impacted by sleep loss. Here we recorded CA1 neuronal activity over 12 h in rats across maze exploration, sleep and sleep deprivation, followed by recovery sleep. We found that SWRs showed sustained or higher rates during sleep deprivation but with lower power and higher frequency ripples. Pyramidal cells exhibited sustained firing during sleep deprivation and reduced firing during sleep, yet their firing rates were comparable during SWRs regardless of sleep state. Despite the robust firing and abundance of SWRs during sleep deprivation, we found that the reactivation and replay of neuronal firing patterns was diminished during these periods and, in some cases, completely abolished compared to ad libitum sleep. Reactivation partially rebounded after recovery sleep but failed to reach the levels found in natural sleep. These results delineate the adverse consequences of sleep loss on hippocampal function at the network level and reveal a dissociation between the many SWRs elicited during sleep deprivation and the few reactivations and replays that occur during these events.