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作者：Barquera, Rodrigo; Del Castillo-Chavez, Oana; Naegele, Kathrin; Perez-Ramallo, Patxi; Hernandez-Zaragoza, Diana Iraiz; Szolek, Andras; Rohrlach, Adam Benjamin; Librado, Pablo; Childebayeva, Ainash; Bianco, Raffaela Angelina; Penman, Bridget S.; Acuna-Alonzo, Victor; Lucas, Mary; Lara-Riegos, Julio Cesar; Moo-Mezeta, Maria Ermila; Torres-Romero, Julio Cesar; Roberts, Patrick; Kohlbacher, Oliver; Warinner, Christina; Krause, Johannes
作者单位：Max Planck Society; Max Planck Society; University of Basque Country; Max Planck Society; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; University of Adelaide; Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); University of Warwick; University of Warwick; Universidad Autonoma de Yucatan; Universidad Autonoma de Yucatan; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Harvard University; Norwegian University of Science & Technology (NTNU); University of Texas System; University of Texas Austin
摘要：The ancient city of Chichen Itza in Yucatan, Mexico, was one of the largest and most influential Maya settlements during the Late and Terminal Classic periods (ad 600-1000) and it remains one of the most intensively studied archaeological sites in Mesoamerica(1-4). However, many questions about the social and cultural use of its ceremonial spaces, as well as its population's genetic ties to other Mesoamerican groups, remain unanswered(2). Here we present genome-wide data obtained from 64 subad...
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作者：Jaffe, Yitzchak; Caramanica, Ari; Price, Max
作者单位：University of Haifa; Vanderbilt University; Durham University
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作者：Dong, Zehao; Huo, Mengwu; Li, Jie; Li, Jingyuan; Li, Pengcheng; Sun, Hualei; Gu, Lin; Lu, Yi; Wang, Meng; Wang, Yayu; Chen, Zhen
作者单位：Tsinghua University; Sun Yat Sen University; Sun Yat Sen University; Nanjing University; Nanjing University; Tsinghua University; Sun Yat Sen University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Hefei National Laboratory; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The recent discovery of superconductivity in La3Ni2O7-delta under high pressure with a transition temperature around 80 K (ref. 1) has sparked extensive experimental(2-6) and theoretical efforts(7-12). Several key questions regarding the pairing mechanism remain to be answered, such as the most relevant atomic orbitals and the role of atomic deficiencies. Here we develop a new, energy-filtered, multislice electron ptychography technique, assisted by electron energy-loss spectroscopy, to addres...
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作者：Gruber, Christoph G.; Frey, Laura; Guntermann, Roman; Medina, Dana D.; Cortes, Emiliano
作者单位：University of Munich; University of Munich; University of Munich
摘要：Covalent organic frameworks (COFs) are a functional material class able to harness, convert and store energy. However, after almost 20 years of research, there are no coherent prediction rules for their synthesis conditions. This is partly because of an incomplete picture of nucleation and growth at the early stages of formation. Here we use the optical technique interferometric scattering microscopy (iSCAT)(1-3) for in operando studies of COF polymerization and framework formation. We observe...
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作者：Sing, David K.; Rustamkulov, Zafar; Thorngren, Daniel P.; Barstow, Joanna K.; Tremblin, Pascal; de Oliveira, Catarina Alves; Beck, Tracy L.; Birkmann, Stephan M.; Challener, Ryan C.; Crouzet, Nicolas; Espinoza, Nestor; Ferruit, Pierre; Giardino, Giovanna; Gressier, Amelie; Lee, Elspeth K. H.; Lewis, Nikole K.; Maiolino, Roberto; Manjavacas, Elena; Rauscher, Bernard J.; Sirianni, Marco; Valenti, Jeff A.
作者单位：Johns Hopkins University; Johns Hopkins University; Open University - UK; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; European Space Agency; European Space Astronomy Center; Space Telescope Science Institute; Cornell University; Leiden University; Leiden University - Excl LUMC; European Space Agency; European Space Research & Technology Centre; University of Bern; University of Cambridge; Space Telescope Science Institute; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Space Telescope Science Institute
摘要：Observations of transiting gas giant exoplanets have revealed a pervasive depletion of methane 1-4 , which has only recently been identified atmospherically 5,6 . The depletion is thought to be maintained by disequilibrium processes such as photochemistry or mixing from a hotter interior 7-9 . However, the interiors are largely unconstrained along with the vertical mixing strength and only upper limits on the CH4 depletion have been available. The warm Neptune WASP-107b stands out among exopla...
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作者：Jiang, Yuehua; Jahagirdar, Balkrishna N.; Reinhardt, R. Lee; Schwartz, Robert E.; Keene, C. Dirk; Ortiz-Gonzalez, Xilma R.; Reyes, Morayma; Lenvik, Todd; Lund, Troy; Blackstad, Mark; Du, Jingbo; Aldrich, Sara; Lisberg, Aaron; Low, Walter C.; Largaespada, David A.; Verfaillie, Catherine M.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
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作者：Wynne-Cattanach, Bethan L.; Couto, Nicole; Drake, Henri F.; Ferrari, Raffaele; Le Boyer, Arnaud; Mercier, Herle; Messias, Marie-Jose; Ruan, Xiaozhou; Spingys, Carl P.; van Haren, Hans; Voet, Gunnar; Polzin, Kurt; Garabato, Alberto C. Naveira; Alford, Matthew H.
作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California Irvine; Massachusetts Institute of Technology (MIT); Institut de Recherche pour le Developpement (IRD); Ifremer; Universite de Bretagne Occidentale; Centre National de la Recherche Scientifique (CNRS); University of Exeter; Boston University; NERC National Oceanography Centre; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Woods Hole Oceanographic Institution; University of Southampton
摘要：Small-scale turbulent mixing drives the upwelling of deep water masses in the abyssal ocean as part of the global overturning circulation1. However, the processes leading to mixing and the pathways through which this upwelling occurs remain insufficiently understood. Recent observational and theoretical work2-5 has suggested that deep-water upwelling may occur along the ocean's sloping seafloor; however, evidence has, so far, been indirect. Here we show vigorous near-bottom upwelling across is...
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作者：[Anonymous]
摘要：Should one principal investigator have the power to determine postdocs' careers? Share your thoughts on academia's dominant funding model in our survey and reader poll.
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作者：Ahmed, Anees; Joseph, Ann M.; Zhou, Jordan; Horn, Veronika; Uddin, Jazib; Lyu, Mengze; Goc, Jeremy; Sockolow, Robbyn E.; Wing, James B.; Vivier, Eric; Sakaguchi, Shimon; Sonnenberg, Gregory F.
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of Osaka; University of Osaka; University of Osaka; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Kyoto University
摘要：Interleukin (IL-)23 is a major mediator and therapeutic target in chronic inflammatory diseases that also elicits tissue protection in the intestine at homeostasis or following acute infection(1-4). However, the mechanisms that shape these beneficial versus pathological outcomes remain poorly understood. To address this gap in knowledge, we performed single-cell RNA sequencing on all IL-23 receptor-expressing cells in the intestine and their acute response to IL-23, revealing a dominance of T ...
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作者：Bader, Jackie E.; Wolf, Melissa M.; Lupica-Tondo, Gian Luca; Madden, Matthew Z.; Reinfeld, Bradley I.; Arner, Emily N.; Hathaway, Emma S.; Steiner, KayLee K.; Needle, Gabriel A.; Hatem, Zaid; Landis, Madelyn D.; Faneuff, Eden E.; Blackman, Amondrea; Wolf, Elysa M.; Cottam, Matthew A.; Ye, Xiang; Bates, Madison E.; Smart, Kyra; Wang, Wenjun; Pinheiro, Laura V.; Christofides, Anthos; Smith, DuPreez; Boussiotis, Vassiliki A.; Haake, Scott M.; Beckermann, Kathryn E.; Wellen, Kathryn E.; Reinhart-King, Cynthia A.; Serezani, C. Henrique; Lee, Cheng-Han; Aubrey, Christa; Chen, Heidi; Rathmell, W. Kimryn; Hasty, Alyssa H.; Rathmell, Jeffrey C.
作者单位：Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; University of Pennsylvania; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of Alberta; Vanderbilt University; University of Pennsylvania; University of Alberta; Vanderbilt University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Tennessee Valley Healthcare System
摘要：Obesity is a leading risk factor for progression and metastasis of many cancers(1,2), yet can in some cases enhance survival(3-5) and responses to immune checkpoint blockade therapies, including anti-PD-1, which targets PD-1 (encoded by PDCD1), an inhibitory receptor expressed on immune cells6-8. Although obesity promotes chronic inflammation, the role of the immune system in the obesity-cancer connection and immunotherapy remains unclear. It has been shown that in addition to T cells, macroph...
