Nature

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• Coevolution of craton margins and interiors during continental break-up AI翻译
  作者：Gernon, Thomas M.; Hincks, Thea K.; Brune, Sascha; Braun, Jean; Jones, Stephen M.; Keir, Derek; Cunningham, Alice; Glerum, Anne
  作者单位：University of Southampton; NERC National Oceanography Centre; Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences; University of Potsdam; University of Birmingham; University of Florence
  摘要：Many cratonic continental fragments dispersed during the rifting and break-up of Gondwana are bound by steep topographic landforms known as 'great escarpments'1-4, which rim elevated plateaus in the craton interior5,6. In terms of formation, escarpments and plateaus are traditionally considered distinct owing to their spatial separation, occasionally spanning more than a thousand kilometres. Here we integrate geological observations, statistical analysis, geodynamic simulations and landscape-e...
• DNA PACKING INFLUENCES THE MAKING OF MEMORIES AI翻译
  作者：[Anonymous]
• India budget: Modi bets big on nuclear energy and space AI翻译
  作者：Padma, T. V.
  摘要：The government has focused on areas of national pride and applied science, as many researchers expected.
• How South Africa can move on from power cuts AI翻译
  作者：Simiyu, Donah
  作者单位：Council for Scientific & Industrial Research (CSIR) - South Africa
  摘要：The country can tackle its energy crisis by diversifying its energy sources, using storage systems and continually optimizing its grid.
• China's robotaxis need regulation AI翻译
  作者：Yang, Hong
  作者单位：University of Reading
  摘要：Letter to the Editor
• Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain AI翻译
  作者：Kefauver, Jennifer M.; Hakala, Markku; Zou, Luoming; Alba, Josephine; Espadas, Javier; Tettamanti, Maria G.; Gajic, Jelena; Gabus, Caroline; Campomanes, Pablo; Estrozi, Leandro F.; Sen, Nesli E.; Vanni, Stefano; Roux, Aurelien; Desfosses, Ambroise; Loewith, Robbie
  作者单位：University of Geneva; University of Geneva; University of Fribourg; University of Geneva; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); University of Fribourg; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN)
  摘要：Biological membranes are partitioned into functional zones termed membrane microdomains, which contain specific lipids and proteins1-3. The composition and organization of membrane microdomains remain controversial because few techniques are available that allow the visualization of lipids in situ without disrupting their native behaviour3,4. The yeast eisosome, composed of the BAR-domain proteins Pil1 and Lsp1 (hereafter, Pil1/Lsp1), scaffolds a membrane compartment that senses and responds t...
• Dissociable hindbrain GLP1R circuits for satiety and aversion AI翻译
  作者：Huang, Kuei-Pin; Acosta, Alisha A.; Ghidewon, Misgana Y.; Mcknight, Aaron D.; Almeida, Milena S.; Nyema, Nathaniel T.; Hanchak, Nicholas D.; Patel, Nisha; Gbenou, Yenoukoume S. K.; Adriaenssens, Alice E.; Bolding, Kevin A.; Alhadeff, Amber L.
  作者单位：Monell Chemical Senses Center; University of Pennsylvania; University of London; University College London
  摘要：The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R) agonists, cause aversive responses such as nausea and vomiting1,2, effects that may contribute to their efficacy. Here, we investigated the brain circuits that link satiety to aversion, and unexpectedly discovered that the neural circuits mediating these effects are functionally separable. Systematic investigation across drug-accessible GLP1R populations revealed that only hindbrain neurons are required for the ...
• Your nose has its own army of immune cells - here's how it protects you AI翻译
  作者：Kozlov, Max
  摘要：Detailed profile of the immune cells in the upper airway could help to improve nasal vaccines.
• Never underestimate RNA: how a molecule went from bit player to star of the show AI翻译
  作者：Mattick, John
  作者单位：University of New South Wales Sydney
  摘要：An insider's story of the discoveries that revealed the dazzling abilities of RNA, and the therapeutic possibilities that emerged.
• In vivo interaction screening reveals liver-derived constraints to metastasis AI翻译
  作者：Borrelli, Costanza; Roberts, Morgan; Eletto, Davide; Hussherr, Marie-Didiee; Fazilaty, Hassan; Valenta, Tomas; Lafzi, Atefeh; Kretz, Jonas A.; Vinzoni, Elena Guido; Karakatsani, Andromachi; Adivarahan, Srivathsan; Mannhart, Ardian; Kimura, Shoichiro; Meijs, Ab; Mhamedi, Farah Baccouche; Acar, Ilhan E.; Handler, Kristina; Ficht, Xenia; Platt, Randall J.; Piscuoglio, Salvatore; Moor, Andreas E.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; University of Basel
  摘要：It is estimated that only 0.02% of disseminated tumour cells are able to seed overt metastases1. While this suggests the presence of environmental constraints to metastatic seeding, the landscape of host factors controlling this process remains largely unclear. Here, combining transposon technology2 and fluorescence niche labelling3, we developed an in vivo CRISPR activation screen to systematically investigate the interactions between hepatocytes and metastatic cells. We identify plexin B2 as...