Nature

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• Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells (vol 627, pg 646, 2024) AI翻译
  作者：Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y.; Silva, John; Mcginnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L.; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S.; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S.; Meng, Raymond; Chiang, Eugene Y.; Johnston, Robert J.; Patil, Namrata S.
• Growth of complete ammonia oxidizers on guanidine AI翻译
  作者：Palatinszky, Marton; Herbold, Craig W.; Sedlacek, Christopher J.; Puehringer, Dominic; Kitzinger, Katharina; Giguere, Andrew T.; Wasmund, Kenneth; Nielsen, Per H.; Dueholm, Morten K. D.; Jehmlich, Nico; Gruseck, Richard; Legin, Anton; Kostan, Julius; Krasnici, Nesrete; Schreiner, Claudia; Palmetzhofer, Johanna; Hofmann, Thilo; Zumstein, Michael; Djinovic-Carugo, Kristina; Daims, Holger; Wagner, Michael
  作者单位：University of Vienna; University of Vienna; Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); Aalborg University; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); University of Vienna; University of Vienna; University of Vienna; European Molecular Biology Laboratory (EMBL); University of Canterbury; University of Portsmouth
  摘要：Guanidine is a chemically stable nitrogen compound that is excreted in human urine and is widely used in manufacturing of plastics, as a flame retardant and as a component of propellants, and is well known as a protein denaturant in biochemistry1-3. Guanidine occurs widely in nature and is used by several microorganisms as a nitrogen source, but microorganisms growing on guanidine as the only substrate have not yet been identified. Here we show that the complete ammonia oxidizer (comammox) Nit...
• AI model collapse might be prevented by studying human language transmission AI翻译
  作者：Smith, Kenny; Kirby, Simon; Guo, Shangmin; Griffiths, Thomas L.
  作者单位：University of Edinburgh; Princeton University
• Multi-pass, single-molecule nanopore reading of long protein strands AI翻译
  作者：Motone, Keisuke; Kontogiorgos-Heintz, Daphne; Wee, Jasmine; Kurihara, Kyoko; Yang, Sangbeom; Roote, Gwendolin; Fox, Oren E.; Fang, Yishu; Queen, Melissa; Tolhurst, Mattias; Cardozo, Nicolas; Jain, Miten; Nivala, Jeff
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Northeastern University; University of Osaka
  摘要：The ability to sequence single protein molecules in their native, full-length form would enable a more comprehensive understanding of proteomic diversity. Current technologies, however, are limited in achieving this goal1,2. Here, we establish a method for the long-range, single-molecule reading of intact protein strands on a commercial nanopore sensor array. By using the ClpX unfoldase to ratchet proteins through a CsgG nanopore3,4, we provide single-molecule evidence that ClpX translocates s...
• Titration of RAS alters senescent state and influences tumour initiation AI翻译
  作者：Chan, Adelyne S. L.; Zhu, Haoran; Narita, Masako; Cassidy, Liam D.; Young, Andrew R. J.; Bermejo-Rodriguez, Camino; Janowska, Aleksandra T.; Chen, Hung-Chang; Gough, Sarah; Oshimori, Naoki; Zender, Lars; Aitken, Sarah J.; Hoare, Matthew; Narita, Masashi
  作者单位：CRUK Cambridge Institute; University of Cambridge; Cancer Research UK; University of Liverpool; Oregon Health & Science University; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Helmholtz Association; German Cancer Research Center (DKFZ); Eberhard Karls University of Tubingen; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Institute of Science Tokyo; Tokyo Institute of Technology
  摘要：Oncogenic RAS-induced senescence (OIS) is an autonomous tumour suppressor mechanism associated with premalignancy1,2. Achieving this phenotype typically requires a high level of oncogenic stress, yet the phenotype provoked by lower oncogenic dosage remains unclear. Here we develop oncogenic RAS dose-escalation models in vitro and in vivo, revealing a RAS dose-driven non-linear continuum of downstream phenotypes. In a hepatocyte OIS model in vivo, ectopic expression of NRAS(G12V) does not induc...
• How can I publish open access when I can't afford the fees? AI翻译
  作者：Forrester, Nikki
• When physicists strove for peace: past lessons for our uncertain times AI翻译
  作者：Lalli, Roberto; Navarro, Jaume
  作者单位：Polytechnic University of Turin; University of Basque Country
  摘要：Can science be a route to peace and common understanding? A glance at the history of one institution shows: only when scientists actively commit to it.
• Stop delaying action on antimicrobial resistance - it is achievable and affordable AI翻译
  作者：Laxminarayan, Ramanan
  摘要：Ensuring that clinics in low- and middle-income countries are well-stocked with high-quality antibiotics could help physicians to treat millions of people each year and slow the spread of drug resistance.
• Islands are rich with languages spoken nowhere else AI翻译
  作者：Liang, Jingwen
• Brain region boosts avoidance of unpleasantness and pain - in mice AI翻译
  作者：Liang, Jingwen