Nature

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• WHY SCIENTISTS ARE JOINING THE RUSH TO BLUESKY AI翻译
  作者：Mallapaty, Smriti
• Isoprene nitrates drive new particle formation in Amazon's upper troposphere AI翻译
  作者：Curtius, Joachim; Heinritzi, Martin; Beck, Lisa J.; Poehlker, Mira L.; Tripathi, Nidhi; Krumm, Bianca E.; Holzbeck, Philip; Nussbaumer, Clara M.; Pardo, Lianet Hernandez; Klimach, Thomas; Barmpounis, Konstantinos; Andersen, Simone T.; Bardakov, Roman; Bohn, Birger; Cecchini, Micael A.; Chaboureau, Jean-Pierre; Dauhut, Thibaut; Dienhart, Dirk; Doerich, Raphael; Edtbauer, Achim; Giez, Andreas; Hartmann, Antonia; Holanda, Bruna A.; Joppe, Philipp; Kaiser, Katharina; Keber, Timo; Klebach, Hannah; Krueger, Ovid O.; Kuerten, Andreas; Mallaun, Christian; Marno, Daniel; Martinez, Monica; Monteiro, Carolina; Nelson, Carolina; Ort, Linda; Raj, Subha S.; Richter, Sarah; Ringsdorf, Akima; Rocha, Fabio; Simon, Mario; Sreekumar, Sreedev; Tsokankunku, Anywhere; Unfer, Gabriela R.; Valenti, Isabella D.; Wang, Nijing; Zahn, Andreas; Zauner-Wieczorek, Marcel; Albrecht, Rachel I.; Andreae, Meinrat O.; Artaxo, Paulo; Crowley, John N.; Fischer, Horst; Harder, Hartwig; Herdies, Dirceu L.; Machado, Luiz A. T.; Poehlker, Christopher; Poeschl, Ulrich; Possner, Anna; Pozzer, Andrea; Schneider, Johannes; Williams, Jonathan; Lelieveld, Jos
  作者单位：Goethe University Frankfurt; Leibniz Association; Leibniz Institut fur Tropospharenforschung (TROPOS); Leipzig University; Max Planck Society; Stockholm University; Stockholm University; Helmholtz Association; Research Center Julich; Universidade de Sao Paulo; Institut de Recherche pour le Developpement (IRD); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); LAERO; Helmholtz Association; German Aerospace Centre (DLR); Johannes Gutenberg University of Mainz; Instituto Nacional de Pesquisas Espaciais (INPE); Institute Nacional de Pesquisas da Amazonia; Helmholtz Association; Karlsruhe Institute of Technology; King Saud University; University of California System; University of California San Diego; Scripps Institution of Oceanography; Universidade de Sao Paulo; Universidade de Sao Paulo
  摘要：New particle formation (NPF) in the tropical upper troposphere is a globally important source of atmospheric aerosols1, 2, 3-4. It is known to occur over the Amazon basin, but the nucleation mechanism and chemical precursors have yet to be identified2. Here we present comprehensive in situ aircraft measurements showing that extremely low-volatile oxidation products of isoprene, particularly certain organonitrates, drive NPF in the Amazonian upper troposphere. The organonitrates originate from ...
• Coupling of unactivated alkyl electrophiles using frustrated ion pairs AI翻译
  作者：Roediger, Sven; Le Saux, Emilien; Boehm, Philip; Morandi, Bill
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Cross-electrophile coupling reactions have evolved into a major strategy for rapidly assembling important organic molecules1. Two readily accessible electrophiles are coupled to form new C-C bonds, providing a key advantage over traditional cross-coupling strategies that require the preformation of reactive organometallic species. Yet, the formation of C(sp3)-C(sp3) bonds that form the core of nearly all organic compounds remains highly challenging with current approaches, calling for the desi...
• Combining quantum processors with real-time classical communication AI翻译
  作者：Vazquez, Almudena Carrera; Tornow, Caroline; Riste, Diego; Woerner, Stefan; Takita, Maika; Egger, Daniel J.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Quantum computers process information with the laws of quantum mechanics. Current quantum hardware is noisy, can only store information for a short time and is limited to a few quantum bits, that is, qubits, typically arranged in a planar connectivity1. However, many applications of quantum computing require more connectivity than the planar lattice offered by the hardware on more qubits than is available on a single quantum processing unit (QPU). The community hopes to tackle these limitation...
• Long-term lineage commitment in haematopoietic stem cell gene therapy AI翻译
  作者：Calabria, Andrea; Spinozzi, Giulio; Cesana, Daniela; Buscaroli, Elena; Benedicenti, Fabrizio; Pais, Giulia; Gazzo, Francesco; Scala, Serena; Lidonnici, Maria Rosa; Scaramuzza, Samantha; Albertini, Alessandra; Esposito, Simona; Tucci, Francesca; Canarutto, Daniele; Omrani, Maryam; De Mattia, Fabiola; Dionisio, Francesca; Giannelli, Stefania; Marktel, Sarah; Fumagalli, Francesca; Calbi, Valeria; Cenciarelli, Sabina; Ferrua, Francesca; Gentner, Bernhard; Caravagna, Giulio; Ciceri, Fabio; Naldini, Luigi; Ferrari, Giuliana; Aiuti, Alessandro; Montini, Eugenio
  作者单位：Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Fondazione Telethon; San Raffaele Telethon Institute For Gene Therapy (Sr-Tiget); University of Trieste; Polytechnic University of Milan; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University
  摘要：Haematopoietic stem cell (HSC) gene therapy (GT) may provide lifelong reconstitution of the haematopoietic system with gene-corrected cells1. However, the effects of underlying genetic diseases, replication stress and ageing on haematopoietic reconstitution and lineage specification remain unclear. In this study, we analysed haematopoietic reconstitution in 53 patients treated with lentiviral-HSC-GT for diverse conditions such as metachromatic leukodystrophy2,3 (MLD), Wiskott-Aldrich syndrome4...
• A step-by-step guide to landing your next job in science AI翻译
  作者：Nordling, Linda
• A plastics treaty is urgently needed, but getting it right will take time AI翻译
  作者：[Anonymous]
• Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake AI翻译
  作者：Tan, Han L.; Yin, Luping; Tan, Yuqi; Ivanov, Jessica; Plucinska, Kaja; Ilanges, Anoj; Herb, Brian R.; Wang, Putianqi; Kosse, Christin; Cohen, Paul; Lin, Dayu; Friedman, Jeffrey M.
  作者单位：Rockefeller University; Howard Hughes Medical Institute; NYU Langone Medical Center; New York University; Stanford University; Rockefeller University; University System of Maryland; University of Maryland Baltimore
  摘要：Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue mass by regulating the activity of specific neural populations controlling appetite and metabolism(1). Leptin regulates food intake by inhibiting orexigenic agouti-related protein (AGRP) neurons and activating anorexigenic pro-opiomelanocortin (POMC) neurons(2). However, whereas AGRP neurons regulate food intake on a rapid time scale, acute activation of POMC neurons has only a minimal effect(3-5). This ha...
• Near-identical macromolecules spontaneously partition into concentric circles AI翻译
  作者：Gong, Hao; Sakaguchi, Yuriko; Suzuki, Tsutomu; Yanagisawa, Miho; Aida, Takuzo
  作者单位：University of Tokyo; University of Tokyo; University of Tokyo; RIKEN
  摘要：Although separation is entropically unfavourable, it is often essential for our life1,2. The separation of very similar macromolecules such as deoxyribonucleic acids (DNAs) and their single nucleotide variants is difficult but holds great advantage for the progress of life science3. Here we report that a particular liquid-liquid phase separation (LLPS) at a solid-liquid interface led to the partitioning of DNAs with nearly identical structures. We found this intriguing phenomenon when we did d...
• Safeguard US-China genome collaboration AI翻译
  作者：Wang, Zhangyu; Du, Li
  作者单位：University of Macau