Nature

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• MCM double hexamer loading visualized with human proteins AI翻译
  作者：Weissmann, Florian; Greiwe, Julia F.; Puhringer, Thomas; Eastwood, Evelyn L.; Couves, Emma C.; Miller, Thomas C. R.; Diffley, John F. X.; Costa, Alessandro
  作者单位：Francis Crick Institute; Francis Crick Institute; University of Copenhagen
  摘要：Eukaryotic DNA replication begins with the loading of the MCM replicative DNA helicase as a head-to-head double hexamer at origins of DNA replication(1-3). Our current understanding of how the double hexamer is assembled by the origin recognition complex (ORC), CDC6 and CDT1 comes mostly from budding yeast. Here we characterize human double hexamer (hDH) loading using biochemical reconstitution and cryo-electron microscopy with purified proteins. We show that the human double hexamer engages D...
• Four game-changing researchers in materials science AI翻译
  作者：Hedley, Esme; Ong, Sandy
  摘要：These scientists are bringing fresh perspectives to solving the world's big challenges in materials.
• Better data sets won't solve the problem - we need AI for Africa to be developed in Africa AI翻译
  作者：Moorosi, Nyalleng
  摘要：Language models developed by big technology companies consistently underperform in African languages. It's time to focus on local solutions.
• Intermittent rate coding and cue-specific ensembles support working memory AI翻译
  作者：Panichello, Matthew F.; Jonikaitis, Donatas; Oh, Yu Jin; Zhu, Shude; Trepka, Ethan B.; Moore, Tirin
  作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute
  摘要：Persistent, memorandum-specific neuronal spiking activity has long been hypothesized to underlie working memory(1,2). However, emerging evidence suggests a potential role for 'activity-silent' synaptic mechanisms(3-5). This issue remains controversial because evidence for either view has largely relied either on datasets that fail to capture single-trial population dynamics or on indirect measures of neuronal spiking. We addressed this controversy by examining the dynamics of mnemonic informat...
• Large language models can help to translate science into real-world impact AI翻译
  作者：Dhakal, Sandeep; Parry, Hazel
  作者单位：Commonwealth Scientific & Industrial Research Organisation (CSIRO)
• Spatially restricted immune and microbiota-driven adaptation of the gut AI翻译
  作者：Mayassi, Toufic; Li, Chenhao; Segerstolpe, Asa; Brown, Eric M.; Weisberg, Rebecca; Nakata, Toru; Yano, Hiroshi; Herbst, Paula; Artis, David; Graham, Daniel B.; Xavier, Ramnik J.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
  摘要：The intestine is characterized by an environment in which host requirements for nutrient and water absorption are consequently paired with the requirements to establish tolerance to the outside environment. To better understand how the intestine functions in health and disease, large efforts have been made to characterize the identity and composition of cells from different intestinal regions(1-8). However, the robustness, nature of adaptability and extent of resilience of the transcriptional ...
• CRISPR patent problems harm Indian farmers AI翻译
  作者：Chaurasia, Anurag
  作者单位：Indian Council of Agricultural Research (ICAR); ICAR - Indian Institute of Vegetable Research
• Claims that dam removals were to blame for Valencia floods are false AI翻译
  作者：de Leaniz, Carlos Garcia; Mouchlianitis, Foivos A.
  作者单位：Universidade de Vigo
• Meet the Latina scientists advancing health and policy AI翻译
  作者：Rodrigues, Meghie
  摘要：Four Latin American researchers reflect on their experiences bridging the gap between science and policy in the region.
• Richard Dawkins's book of the dead is haunted by ghosts of past works AI翻译
  作者：Comfort, Nathaniel
  作者单位：University of California System; University of California Berkeley; Johns Hopkins University