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作者:[Anonymous]
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作者:Yang, Ran; Hunker, Olivia; Wise, Marleigh; Bleichert, Franziska
作者单位:Yale University
摘要:Loading of replicative helicases is obligatory for the assembly of DNA replication machineries. The eukaryotic MCM2-7 replicative helicase motor is deposited onto DNA by the origin recognition complex (ORC) and co-loader proteins as a head-to-head double hexamer to license replication origins. Although extensively studied in budding yeast(1-4), the mechanisms of origin licensing in multicellular eukaryotes remain poorly defined. Here we use biochemical reconstitution and electron microscopy to...
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作者:Baker, Simon
摘要:Many of the solutions to global challenges are coming from this expanding field.
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作者:Crow, James Mitchell
摘要:Finding answers to climate problems - and the financial benefits this might bring - is driving advances.
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作者:Sundaram, Subramanian; Lee, Joshua H.; Bjorge, Isabel M.; Michas, Christos; Kim, Sudong; Lammers, Alex; Mano, Joao F.; Eyckmans, Jeroen; White, Alice E.; Chen, Christopher S.
作者单位:Boston University; Boston University; Harvard University; Universidade de Aveiro; Boston University; Boston University; Boston University
摘要:Natural tissues are composed of diverse cells and extracellular materials whose arrangements across several length scales-from subcellular lengths(1) (micrometre) to the organ scale(2) (centimetre)-regulate biological functions. Tissue-fabrication methods have progressed to large constructs, for example, through stereolithography(3) and nozzle-based bioprinting(4,5), and subcellular resolution through subtractive photoablation(6-8). However, additive bioprinting struggles with sub-nozzle/voxel...
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作者:Heidt, Amanda
摘要:How scientific 'shorthand' could be introducing data distortions into published papers
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作者:Peik, Ekkehard; Kharas, Kaitlin; Chunlai, Li; Abalkina, Anna; Xu, Huji; Yunus, Muhammad; Mbala, Placide; Bahr, Cordelia; Lam, Remi; Freedman, Wendy
摘要:A fraud buster, a nuclear-clock maker and a virus hunter. These are just a few of the remarkable people chosen for this year's Nature's 10.
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作者:Ferry, Georgina
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作者:Chuliver, Mariana; Agnolin, Federico L.; Scanferla, Agustin; Rolando, Mauro Aranciaga; Ezcurra, Martin D.; Novas, Fernando E.; Xu, Xing
作者单位:Museo Argentino de Ciencias Naturales Bernardino Rivadavia (MACN); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Museo Argentino de Ciencias Naturales Bernardino Rivadavia (MACN); University of Birmingham; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
摘要:Anurans are characterized by a biphasic life cycle, with an aquatic larval (tadpole) stage followed by an adult (frog) stage, both connected through the metamorphic period in which drastic morphological and physiological changes occur(1). Extant tadpoles exhibit great morphological diversity and ecological relevance(2), but their absence in the pre-Cretaceous fossil record (older than 145 million years) makes their origins and early evolution enigmatic. This contrasts with the postmetamorphic ...
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作者:Kudiabor, Helena