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作者:Tan, Qing-Hua; Daddi, Emanuele; Magnelli, Benjamin; Correa, Camila A.; Bournaud, Frederic; Adscheid, Sylvia; Zhang, Shao-Bo; Elbaz, David; Gomez-Guijarro, Carlos; Kalita, Boris S.; Liu, Daizhong; Liu, Zhaoxuan; Pety, Jerome; Puglisi, Annagrazia; Schinnerer, Eva; Silverman, John D.; Valentino, Francesco
作者单位:Purple Mountain Observatory, CAS; Chinese Academy of Sciences; Nanjing Institute of Astronomical Optics & Technology, NAOC, CAS; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite Paris Saclay; University of Bonn; University of Tokyo; University of Tokyo; Peking University; University of Tokyo; Universite PSL; Observatoire de Paris; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); University of Southampton; Durham University; Max Planck Society; Johns Hopkins University; European Southern Observatory
摘要:Most stars in today's Universe reside within spheroids, which are bulges of spiral galaxies and elliptical galaxies1,2. Their formation is still an unsolved problem3, 4-5. Infrared/submillimetre-bright galaxies at high redshifts6 have long been suspected to be related to spheroid formation7, 8, 9, 10, 11-12. Proving this connection has been hampered so far by heavy dust obscuration when focusing on their stellar emission13, 14-15 or by methodologies and limited signal-to-noise ratios when look...
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作者:Swift, Joseph; Luginbuehl, Leonie H.; Hua, Lei; Schreier, Tina B.; Donald, Ruth M.; Stanley, Susan; Wang, Na; Lee, Travis A.; Nery, Joseph R.; Ecker, Joseph R.; Hibberd, Julian M.
作者单位:Salk Institute; University of Cambridge; Salk Institute; Salk Institute; Howard Hughes Medical Institute; University of Oxford
摘要:C4 photosynthesis is used by the most productive plants on the planet, and compared with the ancestral C3 pathway, it confers a 50% increase in efficiency1. In more than 60 C4 lineages, CO2 fixation is compartmentalized between tissues, and bundle-sheath cells become photosynthetically activated2. How the bundle sheath acquires this alternate identity that allows efficient photosynthesis is unclear. Here we show that changes to bundle-sheath gene expression in C4 leaves are associated with the...
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作者:Cook, Kristen L.
作者单位:Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
摘要:Climate change and urbanization are exacerbating the effects of flooding. A close look at a Nepalese river reveals that efforts to reduce the impact of floods must consider the geomorphic changes that occur during these extreme events.
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作者:Kudiabor, Helena
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作者:Gao, Teng; Sankaran, Vijay G.
作者单位:Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要:Gene-edited stem cells can be used in regenerative therapies to treat diverse genetic diseases. Tracking the output of these cells over time reveals a commitment to lineages that meet disease-specific needs.
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作者:Binietoglou, Ioannis; Allan, Oscar
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作者:Masood, Ehsan
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作者:Rath, Monalisha; Bergmann, Dominique
作者单位:Stanford University; Howard Hughes Medical Institute
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作者:Koh, Bong Ihn; Mohanakrishnan, Vishal; Jeong, Hyun-Woo; Park, Hongryeol; Kruse, Kai; Choi, Young Jun; Nieminen-Kelhae, Melina; Kumar, Rahul; Pereira, Raquel S.; Adams, Susanne; Lee, Hyuek Jong; Bixel, M. Gabriele; Vajkoczy, Peter; Krause, Daniela S.; Adams, Ralf H.
作者单位:Max Planck Society; Max Planck Society; Max Planck Society; University of Ulsan; Asan Medical Center; University of Ulsan; Asan Medical Center; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Johannes Gutenberg University of Mainz; Goethe University Frankfurt; Institute for Basic Science - Korea (IBS)
摘要:The bone marrow microenvironment is a critical regulator of haematopoietic stem cell self-renewal and fate1. Although it is appreciated that ageing, chronic inflammation and other insults compromise bone marrow function and thereby negatively affect haematopoiesis2, it is not known whether different bone compartments exhibit distinct microenvironmental properties and functional resilience. Here we use imaging, pharmacological approaches and mouse genetics to uncover specialized properties of b...
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作者:Kosse, Christin; Ivanov, Jessica; Knight, Zachary; Pellegrino, Kyle; Friedman, Jeffrey
作者单位:Rockefeller University; Howard Hughes Medical Institute; University of California System; University of California San Francisco
摘要:The brain processes an array of stimuli, enabling the selection of appropriate behavioural responses, but the neural pathways linking interoceptive inputs to outputs for feeding are poorly understood1-3. Here we delineate a subcortical circuit in which brain-derived neurotrophic factor (BDNF)-expressing neurons in the ventromedial hypothalamus (VMH) directly connect interoceptive inputs to motor centres, controlling food consumption and jaw movements. VMHBDNF neuron inhibition increases food i...