Nature

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• A stable zeolite with atomically ordered and interconnected mesopore channel AI翻译
  作者：Lu, Peng; Xu, Jiaoyan; Sun, Yiqing; Guillet-Nicolas, Remy; Willhammar, Tom; Fahda, Mohammad; Dib, Eddy; Wang, Bo; Qin, Zhengxing; Xu, Hongyi; Cho, Jung; Liu, Zhaopeng; Yu, Haijun; Yang, Xiaobo; Lang, Qiaolin; Mintova, Svetlana; Zou, Xiaodong; Valtchev, Valentin
  作者单位：Chinese Academy of Sciences; Qingdao Institute of Bioenergy & Bioprocess Technology, CAS; Stockholm University; Universite de Caen Normandie; Centre National de la Recherche Scientifique (CNRS); China University of Petroleum
  摘要：Zeolites are crystalline microporous materials constructed by corner-sharing tetrahedra (SiO4 and AlO4), with many industrial applications as ion exchangers, adsorbents and heterogeneous catalysts(1-4). However, the presence of micropores impedes the use of zeolites in areas dealing with bulky substrates. Introducing extrinsic mesopores, that is, intercrystal/intracrystal mesopores, in zeolites is a solution to overcome the diffusion barrier(5-8). Still, those extrinsic mesopores are generally...
• More-powerful AI is coming. Academia and industry must oversee it - together AI翻译
  作者：[Anonymous]
  摘要：AI companies want to give machines human-level intelligence. The safest and best results will come when academic and industry scientists oversee it together.
• What if everyone had masked up? Analysis of app data has an answer AI翻译
  作者：[Anonymous]
• Why the genetic-testing revolution left some people behind - and what to do about it AI翻译
  作者：[Anonymous]
• The AI revolution is running out of data. What can researchers do? AI翻译
  作者：Jones, Nicola
  摘要：AI developers are rapidly picking the Internet clean to train large language models such as those behind ChatGPT. Here's how they are trying to get around the problem.
• Digestive contents and food webs record the advent of dinosaur supremacy AI翻译
  作者：Qvarnstrom, Martin; Wernstrom, Joel Vikberg; Wawrzyniak, Zuzanna; Barbacka, Maria; Pacyna, Grzegorz; Gorecki, Artur; Ziaja, Jadwiga; Jarzynka, Agata; Owocki, Krzysztof; Sulej, Tomasz; Marynowski, Leszek; Pienkowski, Grzegorz; Ahlberg, Per E.; Niedzwiedzki, Grzegorz
  作者单位：Uppsala University; UiT The Arctic University of Tromso; University of Silesia in Katowice; Polish Academy of Sciences; W. Szafer Institute of Botany of the Polish Academy of Sciences; Jagiellonian University; Polish Academy of Sciences; Institute of Geological Sciences of the Polish Academy of Sciences; Polish Academy of Sciences; Institute of Paleobiology of the Polish Academy of Sciences; Polish Geological Institute - National Research Institute
  摘要：The early radiation of dinosaurs remains a complex and poorly understood evolutionary event(1-4). Here we use hundreds of fossils with direct evidence of feeding to compare trophic dynamics across five vertebrate assemblages that record this event in the Triassic-Jurassic succession of the Polish Basin (central Europe). Bromalites, fossil digestive products, increase in size and diversity across the interval, indicating the emergence of larger dinosaur faunas with new feeding patterns. Well-pr...
• Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer AI翻译
  作者：Sonke, Gabe S.; van Ommen-Nijhof, Annemiek; Wortelboer, Noor; van der Noort, Vincent; Swinkels, Astrid C. P.; Blommestein, Hedwig M.; Paez, Cristina Guerrero; Mol, Linda; Beeker, Aart; Beelen, Karin; Hamming, Lisanne C.; Heijns, Joan B.; Honkoop, Aafke H.; de Jong, Paul C.; van Rossum-Schornagel, Quirine C.; van Schaik-van de Mheen, Christa; Tol, Jolien; Tromp-van Driel, Cathrien S.; Vrijaldenhoven, Suzan; van Leeuwen-Stok, A. Elise; Konings, Inge R.; Jager, Agnes; de Jong, Paul C.
  作者单位：Netherlands Cancer Institute; Erasmus University Rotterdam; Erasmus MC; Erasmus MC Cancer Institute; Netherlands Cancer Institute; Erasmus University Rotterdam - Excl Erasmus MC; Erasmus University Rotterdam; Spaarne Hospital; Rijnstate Hospital; Medical Center Leeuwarden; Amphia Hospital; Isala Clinics; St. Antonius Hospital Utrecht; Franciscus Gasthuis; Meander Medisch Centrum; Jeroen Bosch Ziekenhuis; Gelre Hospitals; Medical Center Of Alkmaar; Vrije Universiteit Amsterdam; University of Amsterdam
  摘要：Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) in combination with endocrine therapy improve the outcomes of patients with hormone-receptor (HR)-positive, HER2-negative advanced breast cancer and can be used early as first-line treatment or deferred to second-line treatment(1-7). Randomized data comparing the use of CDK4/6i in the first- and second-line setting are lacking. The phase 3 SONIA trial (NCT03425838) randomized 1,050 patients who had not received previous therapy for advanced ...
• Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma AI翻译
  作者：Chen, Yu-Jung; Iyer, Swathi V.; Hsieh, David Chun-Cheng; Li, Buren; Elias, Harold K.; Wang, Tao; Li, Jing; Ganbold, Mungunsarnai; Lien, Michelle C.; Peng, Yu-Chun; Xie, Xuanhua P.; Jayewickreme, Chenura D.; van den Brink, Marcel R. M.; Brady, Sean F.; Lim, S. Kyun; Parada, Luis F.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Rockefeller University; Rockefeller University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; National Institutes of Health (NIH) - USA; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; City of Hope; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
  摘要：Glioblastoma is incurable and in urgent need of improved therapeutics(1). Here we identify a small compound, gliocidin, that kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). IMPDH2 blockade reduces intracellular guanine nucleotide levels, causing nucleotide imbalance, replication stress and tumour cell death(2). G...
• Gamma frequency entrainment attenuates amyloid load and modifies microglia (vol 540, pg 230, 2016) AI翻译
  作者：Iaccarino, Hunter F.; Singer, Annabelle C.; Martorell, Anthony J.; Rudenko, Andrii; Gao, Fan; Gillingham, Tyler Z.; Mathys, Hansruedi; Seo, Jinsoo; Kritskiy, Oleg; Abdurrob, Fatema; Adaikkan, Chinnakkaruppan; Canter, Rebecca G.; Rueda, Richard; Brown, Emery N.; Boyden, Edward S.; Tsai, Li-Huei
• Large global-scale vegetation sensitivity to daily rainfall variability AI翻译
  作者：Feldman, Andrew F.; Konings, Alexandra G.; Gentine, Pierre; Cattry, Mitra; Wang, Lixin; Smith, William K.; Biederman, Joel A.; Chatterjee, Abhishek; Joiner, Joanna; Poulter, Benjamin
  作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University System of Maryland; University of Maryland College Park; Stanford University; Columbia University; Indiana University System; Indiana University Indianapolis; University of Arizona; United States Department of Agriculture (USDA); National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
  摘要：Rainfall events are globally becoming less frequent but more intense under a changing climate, thereby shifting climatic conditions for terrestrial vegetation independent of annual rainfall totals(1-3). However, it remains uncertain how changes in daily rainfall variability are affecting global vegetation photosynthesis and growth(3-17). Here we use several satellite-based vegetation indices and field observations indicative of photosynthesis and growth, and find that global annual-scale veget...