Nature

最新文章

• ChatGPT turns two: how the AI chatbot has changed scientists' lives AI翻译
  作者：Lenharo, Mariana
• How the latest materials are taking biosensors to the next level AI翻译
  作者：Savage, Neil
  摘要：Researchers believe the next generation of wearable devices will transform diagnosis and treatment.
• DEEPMIND AI WEATHER FORECASTER BEATS WORLD-CLASS SYSTEM AI翻译
  作者：Soliman, Alix
• Enhanced silica export in a future ocean triggers global diatom decline (vol 605, pg 696, 2022) AI翻译
  作者：Taucher, Jan; Bach, Lennart T.; Prowe, A. E. Friederike; Boxhammer, Tim; Kvale, Karin; Riebesell, Ulf
• Examining the role of common variants in rare neurodevelopmental conditions AI翻译
  作者：Huang, Qin Qin; Wigdor, Emilie M.; Malawsky, Daniel S.; Campbell, Patrick; Samocha, Kaitlin E.; Chundru, V. Kartik; Danecek, Petr; Lindsay, Sarah; Marchant, Thomas; Koko, Mahmoud; Amanat, Sana; Bonfanti, Davide; Sheridan, Eamonn; Radford, Elizabeth J.; Barrett, Jeffrey C.; Wright, Caroline F.; Firth, Helen V.; Warrier, Varun; Strudwick Young, Alexander; Hurles, Matthew E.; Martin, Hilary C.
  作者单位：Wellcome Trust Sanger Institute; University of London; King's College London; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Exeter; University of Leeds; Saint James's University Hospital; Chapel Allerton Hospital; University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; University of Cambridge; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：Although rare neurodevelopmental conditions have a large Mendelian component(1), common genetic variants also contribute to risk(2,3). However, little is known about how this polygenic risk is distributed among patients with these conditions and their parents nor its interplay with rare variants. It is also unclear whether polygenic background affects risk directly through alleles transmitted from parents to children, or whether indirect genetic effects mediated through the family environment(...
• Has Venus ever had an ocean? Its volcanoes hint at an answer AI翻译
  作者：[Anonymous]
• Brain-penetrating molecule might offer a route to treat glioblastoma tumours AI翻译
  作者：Nengroo, Mushtaq A.; Ben-Sahra, Issam
  作者单位：Northwestern University; Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center; Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern University
  摘要：Gliocidin can target brain tumours by disrupting the production of nucleotides needed for cell growth. The molecule's unusual ability to cross the blood-brain barrier suggests a promising way to develop therapies.
• Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles AI翻译
  作者：Wang, Yimeng; Cao, Siyu; Tone, Daisuke; Fujishima, Hiroshi; Yamada, Rikuhiro G.; Ohno, Rei-ichiro; Shi, Shoi; Matsuzawa, Kyoko; Yada, Saori; Kaneko, Mari; Sakamoto, Hirokazu; Onishi, Taichi; Ukai-Tadenuma, Maki; Ukai, Hideki; Hanashima, Carina; Hirose, Kenzo; Kiyonari, Hiroshi; Sumiyama, Kenta; Ode, Koji L.; Ueda, Hiroki R.
  作者单位：University of Tokyo; RIKEN; Kurume University; RIKEN; University of Tokyo; Waseda University; RIKEN; University of Tsukuba; University of Tokyo; Nagoya University
  摘要：The phosphorylation of synaptic proteins is a significant biochemical reaction that controls the sleep-wake cycle in mammals(1-3). Protein phosphorylation in vivo is reversibly regulated by kinases and phosphatases. In this study, we investigate a pair of kinases and phosphatases that reciprocally regulate sleep duration. First, we perform a comprehensive screen of protein kinaseA (PKA) and phosphoprotein phosphatase (PPP) family genes by generating 40 gene knockout mouse lines using prenatal ...
• X-ray linear dichroic tomography of crystallographic and topological defects AI翻译
  作者：Apseros, Andreas; Scagnoli, Valerio; Holler, Mirko; Guizar-Sicairos, Manuel; Gao, Zirui; Appel, Christian; Heyderman, Laura J.; Donnelly, Claire; Ihli, Johannes
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; United States Department of Energy (DOE); Brookhaven National Laboratory; Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society; Hiroshima University; University of Oxford
  摘要：The functionality of materials is determined by their composition(1-4) and microstructure, that is, the distribution and orientation of crystalline grains, grain boundaries and the defects within them(5,6). Until now, characterization techniques that map the distribution of grains, their orientation and the presence of defects have been limited to surface investigations, to spatial resolutions of a few hundred nanometres or to systems of thickness around 100nm, thus requiring destructive sampl...
• Liquid metal pumps itself out of gels to make artificial vasculature AI翻译
  作者：Bartlett, Michael D.
  作者单位：Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
  摘要：A fresh take on an ancient process for making moulds reverses the usual roles of soft and rigid materials. The resulting process enables complex, 3D channel systems that mimic vasculature to be made in soft biomaterials. Complex channel architectures formed in soft biomaterials.