Nature

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• Stop digital platforms treating people as lab rats AI翻译
  作者：Straub, Vincent
  作者单位：University of Oxford
• Adipose tissue retains an epigenetic memory of obesity after weight loss AI翻译
  作者：Hinte, Laura C.; Castellano-Castillo, Daniel; Ghosh, Adhideb; Melrose, Kate; Gasser, Emanuel; Noe, Falko; Massier, Lucas; Dong, Hua; Sun, Wenfei; Hoffmann, Anne; Wolfrum, Christian; Ryden, Mikael; Mejhert, Niklas; Blueher, Matthias; von Meyenn, Ferdinand
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Karolinska Institutet; Karolinska University Hospital; Leipzig University; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Leipzig University; Leipzig University; Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND; Universidad de Malaga; Stanford University; Stanford University
  摘要：Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity(1,2). However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes(3,4). Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this phenomenon remain largely unknown. Here, by using single-nucleus RNA sequencing, we show t...
• Stress can dull our capacity for joy: mouse brain patterns hint at why AI翻译
  作者：Kozlov, Max
  摘要：Brain circuits linked to resilience or vulnerability to adversity affect an animal's pursuit of pleasure.
• Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei (vol 636, pg 430, 2024) AI翻译
  作者：Beaver, Alexander K.; Keneskhanova, Zhibek; Cosentino, Raul O.; Weiss, Brian L.; Awuoche, Erick O.; Smallenberger, Gretchen M.; Buenconsejo, Gracyn Y.; Crilly, Nathan P.; Smith, Jaclyn E.; Hakim, Jill M. C.; Zhang, Bailin; Bobb, Bryce; Rijo-Ferreira, Filipa; Figueiredo, Luisa M.; Aksoy, Serap; Siegel, T. Nicolai; Mugnier, Monica R.
• Past foraminiferal acclimatization capacity is limited during future warming AI翻译
  作者：Ying, Rui; Monteiro, Fanny M.; Wilson, Jamie D.; Oedalen, Malin; Schmidt, Daniela N.
  作者单位：University of Bristol; University of Bristol; University of Liverpool; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Stockholm University
  摘要：Climate change affects marine organisms, causing migrations, biomass reduction and extinctions(1,2). However, the abilities of marine species to adapt to these changes remain poorly constrained on both geological and anthropogenic timescales. Here we combine the fossil record and a global trait-based plankton model to study optimal temperatures of marine calcifying zooplankton (foraminifera, Rhizaria) through time. The results show that spinose foraminifera with algal symbionts acclimatized to...
• Ancient DNA data hold insights into past organisms and ecosystems - handle them with more care AI翻译
  作者：Bergstrom, Anders; Yates, James A. Fellows; Warinner, Christina
  作者单位：University of East Anglia; Max Planck Society; Harvard University
• Distant sparkles hint at how the Milky Way formed AI翻译
  作者：Welch, Brian
  作者单位：University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
  摘要：The JWST has captured images of the Firefly Sparkle - a galaxy that resembles an early Milky Way - in the process of being assembled from star clusters. The discovery could help to reveal how the Milky Way formed in the early Universe.
• Cephalopod-inspired jetting devices for gastrointestinal drug delivery AI翻译
  作者：Arrick, G.; Sticker, D.; Ghazal, A.; Lu, Y.; Duncombe, T.; Gwynne, D.; Mouridsen, B.; Wainer, J.; Jepsen, J. P. H.; Last, T. S.; Schultz, D.; Hess, K.; Medina De Alba, E.; Min, S.; Poulsen, M.; Anker, C.; Karandikar, P.; Pedersen, H. D.; Collins, J.; Egecioglu, N. E.; Tamang, S.; Cleveland, C.; Ishida, K.; Uhrenfeldt, A. H.; Kuosmanen, J.; Pereverzina, M.; Hayward, A.; Kirk, R. K.; You, S.; Dalsgaard, C. M.; Gunnarsson, S. B.; Patsi, I.; Bohr, A.; Azzarello, A.; Frederiksen, M. R.; Herskind, P.; Li, J.; Roxhed, N.; Rahbek, U. L.; Water, J. J.; Buckley, S. T.; Traverso, G.
  作者单位：Massachusetts Institute of Technology (MIT); Novo Nordisk; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Royal Institute of Technology; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Needle-based injections currently enable the administration of a wide range of biomacromolecule therapies across the body, including the gastrointestinal tract(1-3), through recent developments in ingestible robotic devices(4-7). However, needles generally require training, sharps management and disposal, and pose challenges for autonomous ingestible systems. Here, inspired by the jetting systems of cephalopods, we have developed and evaluated microjet delivery systems that can deliver jets in...
• Huge randomized trial of AI boosts discovery - at least for good scientists AI翻译
  作者：Castelvecchi, Davide
• Strong electron-phonon coupling in magic-angle twisted bilayer graphene AI翻译
  作者：Chen, Cheng; Nuckolls, Kevin P.; Ding, Shuhan; Miao, Wangqian; Wong, Dillon; Oh, Myungchul; Lee, Ryan L.; He, Shanmei; Peng, Cheng; Pei, Ding; Li, Yiwei; Hao, Chenyue; Yan, Haoran; Xiao, Hanbo; Gao, Han; Li, Qiao; Zhang, Shihao; Liu, Jianpeng; He, Lin; Watanabe, Kenji; Taniguchi, Takashi; Jozwiak, Chris; Bostwick, Aaron; Rotenberg, Eli; Li, Chu; Han, Xu; Pan, Ding; Liu, Zhongkai; Dai, Xi; Liu, Chaoxing; Bernevig, B. Andrei; Wang, Yao; Yazdani, Ali; Chen, Yulin
  作者单位：ShanghaiTech University; ShanghaiTech University; University of Oxford; Princeton University; Princeton University; Emory University; University of California System; University of California Santa Barbara; Wuhan University; Beijing Normal University; National Institute for Materials Science; National Institute for Materials Science; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Hong Kong University of Science & Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Basque Foundation for Science; Clemson University; Massachusetts Institute of Technology (MIT); Pohang University of Science & Technology (POSTECH)
  摘要：The unusual properties of superconductivity in magic-angle twisted bilayer graphene (MATBG) have sparked considerable research interest(1-13). However, despite the dedication of intensive experimental efforts and the proposal of several possible pairing mechanisms(14-24), the origin of its superconductivity remains elusive. Here, by utilizing angle-resolved photoemission spectroscopy with micrometre spatial resolution, we reveal flat-band replicas in superconducting MATBG, where MATBG is unali...